Revelation of inherent trends in Mucormycosis resurgence in India: A comparative analysis of past prevalence (pre-Covid-19) and current outbreaks DOI Creative Commons

Pratibha Pant,

Prashant Pant,

Vijay Rani Rajpal

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 9, 2023

Abstract Mucormycosis (MM), commonly referred to as ‘Black Fungus’ was a relatively lesser-known fungal infection until the onset of Covid-19 pandemic. However, amidst global outbreak, it emerged widespread causing significant morbidity and mortality. In India, recorded incidence MM approximately 80% higher than in rest world due prevalence specific pre-disposing factors, causal organisms, clinical manifestations, intriguing epidemiological trends. This study compared case-control studies conducted India before pandemic during current comprehend impact on surge cases. Our findings demonstrate that is distinct condition which not solely dependent Covid-19. Interestingly, trends association with comorbidities like diabetes its greater male gender remains consistent both periods. The increased occurrence appears be more intricately linked challenges management treatment Covid-19, leading emergence novel predisposing factors. indiscriminate use steroids, immunosuppressants, resultant hyperglycemic condition, especially population already burdened comorbidity contributed significantly havoc. suggests raising general awareness about preventive measures, regulation steroid drug misuse can play crucial role curtailing development spread deadly infections future.

Language: Английский

Corona-Associated Mucormycosis: Case Series Reports and Review of the Literature DOI Creative Commons
Andreea Fitero, Nicoleta Negruț, H. John

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(5), P. 305 - 305

Published: April 24, 2024

During the COVID-19 pandemic, a significant increase in cases of mucormycosis was observed patients, especially India, but not exclusively. The presented highlight heterogeneous nature mucormycosis, emphasizing importance recognizing predisposing factors, such as immunosuppression, due to comorbidities or medication. Diagnosing poses challenge nonspecific clinical manifestations, requiring multidisciplinary approach for accurate diagnosis. Treatment involves multi-pronged centered around early initiation antifungal therapy alongside surgical intervention and management underlying conditions, with an emphasis on controlling immunosuppression. Understanding relationship between factors is fundamental developing prevention treatment strategies.

Language: Английский

Citations

1
Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis DOI

Mansi Tanwar,

Anamika Singh, T.P. Singh

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(5), P. 1431 - 1457

Published: April 29, 2024

Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19 pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to excessive steroid and antibiotic use, poor hospital hygiene, crowded settings. Major contributing factors include diabetes weakened immune systems. main manifesting forms of CAM─cutaneous, pulmonary, deadliest, rhinocerebral─and disseminated infections elevated mortality rates 85%. Recent focus lies on small-molecule inhibitors due their advantages over standard treatments like surgery liposomal amphotericin B (which carry several long-term adverse effects), offering potential central nervous system penetration, diverse targets, simpler dosing owing small size, rendering ability traverse blood–brain barrier via passive diffusion facilitated by phospholipid membrane. Adaptation versatility mucormycosis are multitude virulence factors, enabling pathogen dynamically respond various environmental stressors. A comprehensive understanding these mechanisms imperative for devising effective therapeutic interventions against this highly opportunistic that thrives immunocompromised individuals through its angio-invasive nature. Hence, Review delineates principal it employs persist challenging host environments, current progress developing them.

Language: Английский

Citations

1
Integrating In-silico and In-vitro approaches to identify plant-derived bioactive molecules against spore coat protein CotH3 and high affinity iron permease FTR1 of Rhizopus oryzae DOI Creative Commons
Lovely Gupta, Pawan Kumar, Pooja Sen

et al.

Current Research in Microbial Sciences, Journal Year: 2024, Volume and Issue: 7, P. 100270 - 100270

Published: Jan. 1, 2024

is one of the major causative agents mucormycosis. The disease has a poor prognosis with high mortality rate, and resistance towards current antifungal drugs poses additional concern. treatment complicated antifungals; therefore, surgical approach preferred in many cases. A comprehensive understanding pathogenicity-associated virulence factors

Language: Английский

Citations

1
COVID-19 associated Mucormycosis among ICU patients: risk factors, control, and challenges DOI Creative Commons
Rehab Mahmoud Abd El-Baky,

Esraa R Shady,

Ramadan Yahia

et al.

AMB Express, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 22, 2023

Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is still difficult to be controlled. spread of this virus and the emergence new variants are considered a great challenge worldwide. Disturbance in infection control guidelines implementation, use steroids, antibiotics, hospital crowdedness, repeated oxygen masks during management critically ill COVID-19 patients lead an increase rate opportunistic infections. So, need fight both with its different pathogens including bacteria fungi especially diabetes mellitus, malignancy, or those who undergo hemodialysis receive deferoxamine. During pandemic, many cases Mucormycosis associated were observed countries. In review, we discuss risk factors that chance by pathogens, fungal recent challenges, measures.

Language: Английский

Citations

3
Rise of mucormycosis during the COVID-19 pandemic and the challenges faced. DOI

Malavika Kottarathil,

Premamalini Thayanidhi,

P Sathyamurthy

et al.

PubMed, Journal Year: 2023, Volume and Issue: 9(1), P. 44 - 55

Published: March 1, 2023

Mucormycosis (previously called zygomycosis) is a diverse group of increasingly recognized and frequently fatal mycotic diseases caused by members the class zygomycetes. around 80 times more common in India, compared to other developed countries, with frequency 0.14 cases per 1,000 population. The most frequent causative agent mucormycosis following genera from Order Mucorales Rhizopus, Mucor, Rhizomucor, Absidia, Apophysomyces, Cunninghamella, Saksenaea. major risk factors for development are diabetic ketoacidosis, deferoxamine treatment, cancer, solid organ or bone marrow transplantations, prolonged steroid use, extreme malnutrition, neutropenia. clinical forms rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal. During second wave COVID-19, there was rapid increase severity than before. Amphotericin B currently found be an effective drug as it have broad-spectrum activity posaconazole used salvage therapy. Newer triazole isavuconazole also against mucormycosis. This study aimed review various studies on laboratory diagnosis treatment

Language: Английский

Citations

3
Evaluation of Clinical Manifestations, Pattern of Involvement, and Surgical Outcomes in Patients with Post Covid-19 Head and Neck Mucormycosis Infection among Patients Admitted To Namazi Hospital, Shiraz, Iran (2021-2022) DOI Creative Commons
Mehryar Nahaei, Gholamreza Motazedian, Aliakbar Mohammadi

et al.

WORLD JOURNAL OF PLASTIC SURGERY, Journal Year: 2023, Volume and Issue: 12(3), P. 64 - 72

Published: Oct. 1, 2023

Evaluation of Clinical Manifestations, Pattern Involvement, and Surgical Outcomes in Patients with Post Covid-19 Head Neck Mucormycosis Infection among Admitted To Namazi Hospital, Shiraz, Iran (2021-2022)

Language: Английский

Citations

1
Genetic Basis for Mucormycosis Progression in COVID-19 Patients: From Susceptibility to Severity DOI Creative Commons
Jethendra Kumar Muruganantham, Ramakrishnan Veerabathiran

Infectious Diseases & Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: March 26, 2024

Abstract The dynamics of COVID-19 and mucormycosis reveal a complex interplay genetic factors that influence the susceptibility, severity, immune responses. COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits an increased incidence mucormycosis, particularly in individuals with comorbidities or corticosteroid therapy. Mucormycosis is fungal infection affects sinuses, orbits, lungs demands timely intervention antifungal medications surgery because its life-threatening nature. Research on underpinnings this intersection has unveiled key insights into pathogenicity Mucorales. Breakthroughs tools have exposed virulence factors, such as CotH protein family high-affinity iron-uptake mechanisms. Genetic susceptibility pivotal element identifying at risk developing facilitating early detection, allowing for personalized treatment strategies. DPP9, MIF , TYK2 are among genes implicated emphasizing intricate relationship between makeup viral response. landscape extends to entry mechanisms, thereby affecting efficiency. Specific polymorphisms IFNAR2, OAS3 associated indicating shared bases hospitalized cases. genetically predisposed, immunocompromised individuals. challenge lies understanding influencing offering pathogenesis potential therapeutic avenues. Organ transplantation adds another layer, increasing infections mucormycosis. impact immunosuppression severity remains elusive, necessitating ongoing research immunological Despite challenges posed emerging SARS-CoV-2 variants, connection presents opportunity treatment, targeted interventions, refined public health

Language: Английский

Citations

0
A Rare Case of Maxillary Mucormycosis in a Child With Juvenile Diabetes Mellitus DOI Open Access

Parmarth M Sonpal,

Bhushan P Mundada,

Nitin Bhola

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Mucor and Rhizopus species are recognized as the primary culprits responsible for mucormycosis, a severe fungal infection known its opportunistic nature. This primarily targets individuals with compromised immune systems, including those diabetes mellitus patients undergoing glucocorticoid therapy, where response is weakened. article aims to underscore pivotal role of prompt diagnosis intensive treatment in managing particularly pediatric patients, it can avert death mitigate serious morbidity. case report emphasizes urgency identifying infections early on subsequently treating them aggressively prevent adverse outcomes. It highlights potential excellent outcomes when mucormycosis promptly diagnosed managed therapy. By doing so, significant morbidity mortality associated this condition be effectively prevented, underscoring importance vigilance proactive management predisposing factors infections.

Language: Английский

Citations

0
Biotic environment reinforcing the pertinacious clinically relevant COVID-19 associated mucormycosis: First report from Kashmir valley, India DOI
Insha Amin,

Riasa Zaffar,

Ruqeya Nazir

et al.

Biologia, Journal Year: 2024, Volume and Issue: 79(8), P. 2545 - 2555

Published: July 12, 2024

Language: Английский

Citations

0
Demographic and Clinical Characteristics of COVID-19 Patients with Mucormycosis DOI
Ali Moshki,

Soha Mohammadi,

Tayebe Salehi

et al.

Journal of Research in Applied and Basic Medical Sciences, Journal Year: 2024, Volume and Issue: 10(3), P. 233 - 239

Published: July 1, 2024

Language: Английский

Citations

0