Administration Time and Dietary Patterns Modified the Effect of Inulin on CUMS‐Induced Anxiety and Depression DOI
Ping Chen, Xiaofang Li, Ying Yu

et al.

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 67(8)

Published: Feb. 22, 2023

Prebiotics exert anxiolytic and antidepressant effects through the microbiota-gut-brain axis in animal models. However, influence of prebiotic administration time dietary pattern on stress-induced anxiety depression is unclear. In this study, whether can modify effect inulin mental disorders within normal high-fat diets are investigated.Mice subjected to chronic unpredicted mild stress (CUMS) administered with morning (7:30-8:00 am) or evening pm) for 12 weeks. Behavior, intestinal microbiome, cecal short-chain fatty acids, neuroinflammatory responses, neurotransmitters measured. A diet aggravated neuroinflammation more likely induce depression-like behavior (p < 0.05). Morning treatment improves exploratory sucrose preference better Both treatments decrease response 0.05), a evident trend administration. Furthermore, tends affect brain-derived neurotrophic factor neurotransmitters.Administration patterns seem depression. These results provide basis assessing interaction patterns, providing guidance precise regulation prebiotics neuropsychiatric disorders.

Language: Английский

Advances in Leaf Plant Bioactive Compounds: Modulation of Chronic Inflammation Related to Obesity DOI Open Access
Jorge Gomes Lopes Barros, Ana S. Abraão, Irene Gouvinhas

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3358 - 3358

Published: April 3, 2025

Over the years, there has been a tendency for an increase in global obesity. The World Health Organization's (WHO) 2024 report states that 2019, more than one billion people were obese, and this condition was responsible five million deaths, being obesity is prevalent among adults compared to adolescents children. Obesity chronic disease characterized by alterations adipose tissue. When excessive food consumed energy expenditure low, tissue undergoes hypertrophy hyperplasia. This process activates B cells induces transition of anti-inflammatory M2-like macrophages into pro-inflammatory M1-like macrophages. cells, acting as inflammatory mediators, stimulate CD8+ T promote macrophage infiltration tissues. triggers inflammation, increases oxidative stress, ultimately leads cellular death. During cytokines occurs along with decrease cytokines. By contrast, stress related reactive oxygen species (ROS), oxidation biomolecules, antioxidants. mechanism can be mitigated through several healthy lifestyle changes, primarily including regular physical activity eating. These factors help reduce mediators ROS, lowering inflammation stress. Therefore, review article focuses on studying bioactive compounds present edible leaves Annona cherimola Mill., Ipomoea batata (L.) Poir., Colocasia esculenta Schott, Eriobotrya japonica, Cymbopogon citratus, Psidium guajava (L.), Smallanthus sonchifolius evaluate their effects mechanisms involved

Language: Английский

Citations

0
Apigenin-loaded nanoparticles for obesity intervention through immunomodulation and adipocyte browning DOI
Neda Mohaghegh,

A. Iyer,

Ethan Wang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113670 - 113670

Published: April 1, 2025

Language: Английский

Citations

0
Walnut‐derived peptides combined with intermittent fasting alleviated obesity by modulating gut microbiota and liver metabolome in high‐fat‐diet‐induced obesity mice DOI
Jing Li,

Pan Hou,

Lili Sun

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract BACKGROUND This study aimed to investigate the anti‐obesity mechanism of walnut‐derived peptides (WMP) combined with intermittent fasting (IF) through modulating gut microbiota–liver metabolism axis in high‐fat‐diet (HFD)‐induced obese mice, providing theoretical support for dietary intervention strategies. METHODS Fifty C57BL/6 mice were divided into five groups ( n = 10): normal diet, HFD, WMP, IF and WMP + IF, an 8‐week intervention. Biochemical analysis, 16S rRNA sequencing, untargeted liver metabolomics employed explore underlying mechanisms. RESULTS significantly alleviated hyperlipidemia, glucose disorders, insulin resistance, visceral fat deposition HFD while suppressing systemic inflammation. Gut microbiota analysis revealed reduced abundance Firmicutes , Kineothrix Dubosiella along a decreased / Bacteroidota (F/B) ratio, whereas CAG‐873 enriched. Correlation demonstrated positive associations between obesity‐related markers (lipid profiles, dysfunction, pro‐inflammatory cytokines), exhibited negative correlations. Untargeted identified upregulated levels 16‐hydroxypalmitic acid 13‐S‐hydroxyoctadecadienoic (13(S)‐HODE), alongside activation ABC transporters galactose pathways. Notably, 13(S)‐HODE showed correlations F/B but . CONCLUSION The synergistic effects are mediated restoring microbial balance reprogramming hepatic metabolic These findings highlight novel mechanisms involving gut–liver axis, offering innovative strategies obesity prevention natural bioactive compounds interventions. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease DOI Creative Commons
Shiqi Hao, Liang Ming, Yafei Li

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 1, 2022

Non-alcoholic fatty liver disease (NAFLD) is a common metabolic of life, usually caused by unhealthy diet and lifestyle. Compared to normal individuals, the structure intestinal flora NAFLD patients altered accordingly. This study investigates effect camel milk on regulation in mice with high-fat diet-induced NAFLD. model was established feeding C57BL/6J for 12 weeks, meanwhile (3.0 g/kg/d), cow silymarin (200 mg/kg/d) were administered gavage, respectively. Food intake changes physiological indexes observed recorded. The 16S rRNA gene V3-V4 region sequenced diversity function predicted colon contents from different group. results showed that enhanced glucolipid metabolism downregulate levels blood glucose triglyceride (TG) serum, reduced lipid accumulation level TG improved tissue ( p &lt; 0.05). Meanwhile, had positive modulatory mice, increasing relative abundance beneficial bacteria decreasing harmful similar effect. At genus level, increased Bacteroides , norank_f_ Muribaculaceae Alloprevotella decreased Dubosiella Coriobacteriaceae_UCG-002 Camel also Carbohydrate metabolism, Amino acid Energy Metabolism cofactors vitamins Lipid thus reducing degree hepatic maintaining liver. In conclusion, can improve enhance substance energy which has alleviating improving flora.

Language: Английский

Citations

15
Administration Time and Dietary Patterns Modified the Effect of Inulin on CUMS‐Induced Anxiety and Depression DOI
Ping Chen, Xiaofang Li, Ying Yu

et al.

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 67(8)

Published: Feb. 22, 2023

Prebiotics exert anxiolytic and antidepressant effects through the microbiota-gut-brain axis in animal models. However, influence of prebiotic administration time dietary pattern on stress-induced anxiety depression is unclear. In this study, whether can modify effect inulin mental disorders within normal high-fat diets are investigated.Mice subjected to chronic unpredicted mild stress (CUMS) administered with morning (7:30-8:00 am) or evening pm) for 12 weeks. Behavior, intestinal microbiome, cecal short-chain fatty acids, neuroinflammatory responses, neurotransmitters measured. A diet aggravated neuroinflammation more likely induce depression-like behavior (p < 0.05). Morning treatment improves exploratory sucrose preference better Both treatments decrease response 0.05), a evident trend administration. Furthermore, tends affect brain-derived neurotrophic factor neurotransmitters.Administration patterns seem depression. These results provide basis assessing interaction patterns, providing guidance precise regulation prebiotics neuropsychiatric disorders.

Language: Английский

Citations

9