The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischaemic heart failure

Cardiovascular Research, Journal Year: 2024, Volume and Issue: 120(10), P. 1126 - 1137

Published: April 29, 2024

Cardiac energy metabolism is perturbed in ischaemic heart failure and characterized by a shift from mitochondrial oxidative to glycolysis. Notably, the failing relies more on ketones for than healthy heart, an adaptive mechanism that improves energy-starved status of heart. However, whether this can be implemented therapeutically remains unknown. Therefore, our aim was determine if increasing ketone delivery via ketogenic diet improve outcomes failure.

Language: Английский

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Alteration of the gut microbiome in patients with heart failure: a systematic review and meta-analysis

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 192, P. 106647 - 106647

Published: May 23, 2024

Language: Английский

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Role of Trimethylamine N-Oxide in Heart Failure

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(7)

Published: July 2, 2024

Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural functional abnormalities of the heart. HF often final stage all cardiovascular diseases significant risk factor for sudden arrest, death, liver kidney failure. Current pharmacological treatments can only slow progression recurrence HF. With advancing research into gut microbiome its metabolites, one such trimethylamine N-oxide (TMAO)—has been implicated in advancement correlated with poor prognosis patients However, precise role TMAO has not yet clarified. This review highlights concludes available evidence potential mechanisms associated HF, hope contributing new insights diagnosis prevention

Language: Английский

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The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

The gut microbiota (GM) plays a critical role in regulating human physiology, with dysbiosis linked to various diseases, including heart failure (HF). HF is complex syndrome significant global health impact, as its incidence doubles each decade of life, and prevalence peaks individuals over 80 years. A bidirectional interaction exists between GM HF, where alterations can worsen the disease's progression. "gut hypothesis HF" suggests that HF-induced changes, such reduced intestinal perfusion altered motility, negatively impact composition, leading increased permeability, release GM-derived metabolites into bloodstream, systemic inflammation. This process creates vicious cycle further deteriorates function. metabolites, trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), secondary bile (BAs), influence gene expression through epigenetic mechanisms, DNA methylation histone modifications. These changes may play crucial mediating effects dysbiotic microbial linking them cardiac contributing progression HF. particularly relevant older individuals, aging itself has been associated both cumulative alterations, intensifying interplay GM, increasing risk elderly. Despite growing body evidence, modifications, remains poorly understood. dynamic nature epigenetics shaped by factors age, diet, lifestyle, presents challenges elucidating precise mechanisms underlying this relationship. Future research should prioritize innovative approaches overcome these limitations. By identifying specific metabolite-induced modifications modulating composition function novel personalized therapeutic strategies for prevention and/or treatment be developed. Moreover, targeted focusing specifically on understanding intricate connections epigenetics, during aging.

Language: Английский

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Gut Failure: A Review of the Pathophysiology and Therapeutic Potentials in the Gut–Heart Axis

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(7), P. 2567 - 2567

Published: March 29, 2023

Despite considerable advances in the field, heart failure (HF) still poses a significant disease burden among affected individuals since it continues to cause high morbidity and mortality rates. Inflammation is considered play key role progression, but exact underlying pathophysiological mechanisms involved have not yet been fully elucidated. The gut, as potential source of inflammation, could feasibly explain state low-grade inflammation seen patients with chronic HF. Several derangements composition microbiota population, coupled an imbalance between favorable harmful metabolites followed by gut barrier disruption eventually bacterial translocation, contribute cardiac dysfunction aggravate On other hand, HF-associated congestion hypoperfusion alters intestinal function, thereby creating vicious cycle. Based on this evidence, novel pharmaceutical agents developed their therapeutic use has tested both animal human subjects. ultimate goal these efforts reverse aforementioned block cascade. This review summarizes gut-related causative pathways implicated HF pathophysiology, well associated interventions described literature.

Language: Английский

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Recent Advances in Microbiota-Associated Metabolites in Heart Failure

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2313 - 2313

Published: Aug. 21, 2023

Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney death. The gut microbiota its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in literature on role specific development, this review highlights summarizes current evidence underlying mechanisms associated with We found that microbiota-derived short chain fatty acids, bile branched-chain amino tryptophan indole derivatives well trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles promoting through various mechanisms. Mainly, they modulate complex signaling pathways nuclear kappa-light-chain-enhancer activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, Protein kinase RNA-like endoplasmic reticulum kinase. also highlighted beneficial other cardiovascular metabolic diseases.

Language: Английский

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Causality Investigation between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4544 - 4544

Published: Oct. 26, 2023

Various studies have highlighted the important associations between obstructive sleep apnea (OSA) and gut microbiota related metabolites. Nevertheless, establishment of causal relationships these remains to be determined. Multiple mendelian randomization (MR) analyses were performed genetically predict causative impact 196 83 metabolites on OSA. Two-sample MR was used assess potential association, causality evaluated using inverse variance weighted (IVW), MR-Egger, median (WM) methods. Multivariable (MVMR) employed ascertain independence linked Additionally, Cochran’s Q test, Egger intercept test Steiger for sensitivity analyses. The analysis revealed that genus_Ruminococcaceae (UCG009) (PIVW = 0.010) genus_Subdoligranulum 0.041) associated with an increased risk OSA onset. Conversely, Family_Ruminococcaceae 0.030), genus_Coprococcus2 (PWM 0.025), genus_Eggerthella 0.011), genus_Eubacterium (xylanophilum_group) 0.001) negatively Among evaluated, 3-dehydrocarnitine, epiandrosterone sulfate, leucine determined independent factors Moreover, reverse demonstrated a suggestive association exposure six taxa. This study offers compelling evidence regarding beneficial or detrimental its risk, thereby providing new insights into mechanisms microbiome-mediated development.

Language: Английский

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Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: May 17, 2022

Background Recent data indicate the importance of gut-kidney axis in pathogenesis Immunoglobulin A nephropathy (IgAN). Growing evidence suggests alterations diversity and composition gut microbiome among patients with IgAN, however, details are not yet fully understood. Methods Eligible studies comparing between IgAN non-IgAN individuals were systematically searched from PubMed, Embase, Web Science, Cochrane Library, China National Knowledge Infrastructure, ClinicalTrials.gov . The primary outcomes alpha- beta-diversity, differences microbiota persons. Qualitative analysis meta-analysis performed according to available data. Results Eleven cross-sectional studies, including 409 243 healthy controls, enrolled. No significant enrichment bacteria found individuals, whereas beta-diversity consistently showed microbial dissimilarities two groups. Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Fusobacteria , Verrucomicrobia dominant phyla, no controls at phylum level. genera, Streptococcus Paraprevotella a higher proportion compared Fusicatenibacter lower abundance meta-analysis. analyses suggested that Escherichia-Shigella might be increased patients; Clostridium, Prevotella 9 ,and Roseburia members Ruminococcaceae Lachnospiraceae families, likely have decreased abundances individuals. Conclusion Gut dysbiosis was demonstrated which involved IgAN. Further needed confirm findings this study, due substantial heterogeneity. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ identifier PROSPERO (CRD42022304034).

Language: Английский

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Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Alterations

Biomedicines, Journal Year: 2022, Volume and Issue: 10(4), P. 809 - 809

Published: March 30, 2022

Growing evidence suggests an altered gut microbiome in patients with heart failure (HF). However, the exact interrelationship between microbiota, HF, and its consequences on metabolome are still unknown. We thus aimed here to decipher association severity progression of HF composition circulating metabolites. Using a mouse model transverse aortic constriction (TAC), bacterial diversity was found be significantly lower mice as early day 7 post-TAC compared Sham controls (p = 0.03), gradual progressive decrease alpha-diversity days 7, 14, 42 0.014, p 0.0016, 0.0021) 0, which coincided compensated hypertrophy, maladaptive overtly failing hearts, respectively. Strikingly, segregated analysis based cardiac dysfunction (EF < 40% vs. EF 40−55%) manifested marked differences abundance grouping several taxa. Multivariate plasma metabolites produced strong correlation metabolic alterations, such reduced short-chain fatty acids increase primary bile acids, differential distinct bacteria HF. In conclusion, we showed that begets likely via vicious cycle products.

Language: Английский

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Gut microbiota and integrative traditional Chinese and western medicine in prevention and treatment of heart failure

Phytomedicine, Journal Year: 2023, Volume and Issue: 117, P. 154885 - 154885

Published: May 23, 2023

Language: Английский

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