Traditional Chinese Medicine, Journal Year: 2024, Volume and Issue: 13(08), P. 1906 - 1913
Published: Jan. 1, 2024
Language: Английский
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 28, 2025
IgA nephropathy (IgAN) is related to the balance of gut microbiota. However, it unclear whether changes in microbiota can cause IgAN or attenuate its progression. This study employed and human microbiota-associated (HMA)-IgAN models investigate impact on alteration mechanisms by which might trigger IgAN. Furthermore, this examined effects chitooligosaccharides (COS) COS formulation (COSF) with microbiota-targeting function enhancing intestinal barrier renal functions. These results revealed that led a reduction α-diversity structural alterations microbiota, characterized an increase Shigella sonnei, Streptococcus danieliae, Desulfovibrio fairfieldensis, decrease Bifidobacterium pseudolongum Clostridium leptum. There was also imbalance B-cell immunity level tight junction proteins (ZO-1 Occludin). Intestinal mucosal immune-related (Clostridium leptum, unclassified Lachnospiraceae NK4Al36 group, Clostridia vadinBB60 Oscillospiraceae, Roseburia) were enriched through targeted modulation COS/COSF, ZO-1 expression reducing APRIL/BAFF overexpression, thereby damage In conclusion, clarified kidney-gut crosstalk between IgAN, providing scientific evidence for developing microbiota-targeted food interventions improve outcomes.
Language: Английский
Citations
2
Toxins, Journal Year: 2023, Volume and Issue: 15(2), P. 115 - 115
Published: Jan. 31, 2023
During the past decades, gut microbiome emerged as a key player in kidney disease. Dysbiosis-related uremic toxins together with pro-inflammatory mediators are main factors deteriorating function. The toxicity of compounds has been well-documented plethora pathophysiological mechanisms disease, such cardiovascular injury (CVI), metabolic dysfunction, and inflammation. Accumulating data on detrimental effect solutes disease supported development many strategies to restore eubiosis. Fecal microbiota transplantation (FMT) spread an encouraging treatment for different dysbiosis-associated disorders. In this scenario, flourishing studies indicate that fecal could represent novel reduce accumulation. Here, we present state-of-the-art concerning application FMT eubiosis reverse retention toxins.
Language: Английский
Citations
19
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: Oct. 20, 2022
Gut microbiota has been reported to play an important role in diabetic kidney disease (DKD), however, the alterations of gut bacteria have not determined.Studies comparing differences microbiome between patients with DKD and non-DKD individuals using high-throughput sequencing technology, were systematically searched reviewed. Outcomes set as bacterial diversity, microbial composition, correlation clinical parameters DKD. Qualitative data summarized compared through a funnel R script, quantitative estimated by meta-analysis.A total 15 studies 1640 participants included, comparisons conducted DKD, diabetes mellitus (DM), non-diabetic (NDKD), healthy controls. There no significant α-diversity DM, NDKD, lower richness was found Different compositions subjects. The phylum Actinobacteria be enriched At genus level, we enrichment Hungatella, Bilophila, Escherichia showed abundances Faecalibacterium those NDKD. genera Butyricicoccus, Faecalibacterium, Lachnospira depleted controls, whereas Escherichia, lactobacillus significantly enriched. Ruminococcus torques group demonstrated inversely correlated glomerular filtration rate DKD.Gut characterized Hungatella depletion butyrate-producing bacteria, which might associated occurrence development Further are still needed validate these findings, due substantial heterogeneity.https://www.crd.york.ac.uk/prospero/, identifier CRD42022340870.
Language: Английский
Citations
27
Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2407 - 2407
Published: May 22, 2023
Although recent research suggests that alterations in gut microbiota and metabolites play a critical role the pathophysiology of immunoglobulin A nephropathy (IgAN), causal relationship between specific intestinal flora risk IgAN remains unclear.This study employed Mendelian randomization (MR) to investigate association IgAN. To explore potential associations various outcomes, four MR methods were applied: inverse variance weighted (IVW), MR-Egger, median, mode. If results are inconclusive, we prefer IVW as primary outcome. Additionally, MR-PRESSO-Global, Cochrane's Q tests used detect heterogeneity pleiotropy. The stability findings was assessed using leave-one-out approach, strength exposure outcome tested Bonferroni correction. Additional clinical samples utilized validate randomization, outcomes visualized through an ROC curve, confusion matrix, correlation analysis.This examined total 15 211 microorganisms. Among them, eight bacteria one metabolite found be associated with (p < 0.05). Bonferroni-corrected test reveals only Class. Actinobacteria (OR: 1.20, 95% CI: 1.07-1.36, p = 0.0029) have significant According test, there is no substantial across different single-nucleotide polymorphisms > Furthermore, MR-Egger MR-PRESSO-Global 0.05) showed evidence No reverse or Clinical specimens demonstrated effectiveness accuracy distinguishing patients from those other glomerular diseases (AUC 0.9, 0.78-1.00). our analysis revealed abundance increased albuminuria (r 0.85) poorer prognosis 0.01).Through analysis, established link incidence Moreover, validation fecal indicated might onset This finding could provide valuable biomarkers for early, noninvasive detection disease therapeutic targets
Language: Английский
Citations
16
Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(1)
Published: Jan. 1, 2024
Abstract Objective The study aimed to conduct a bibliometric analysis of mucosal immunity in IgA nephropathy (IgAN) and indicate its current status, hot sopts, direction future studies. Methods literature data was collected from the Web Science Core Collection. CiteSpace 6.1.R3 employed visualization nephropathy, including authors, countries, journals, keywords, organizations, references, bursts keywords timeline keyword clusters reference clusters. Results A total 315 publications 1990 2022 were included. number articles this field has increased recent years. Suzuki H, Coppo R, Feehally J took first place parallelly with 18 articles. Japan contributes most articles, accounting for 27.3% all publications. institutions Juntendo University Alabama Birmingham. 453 concluded analysis, which mainly focus on pathogenesis therapy IgAN. top five co‐cited cluster are “aberrantly glycosylated IgA,” “corticosteroids,” “animal models,” “ o ‐glycosylationm” “microRNA‐630.” recently burst is “tonsillectomy” “gut.” Conclusion This systematically analyze IgAN, obtained status indicated research hotspots development trends. gut microbiota related therapy‐targeted might be hotspot.
Language: Английский
Citations
6
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14
Published: June 9, 2023
Background: The gut-kidney axis refers to the interaction between gastrointestinal tract and kidneys, its disorders have become increasingly important in development of kidney diseases. aim this study is identify current research hotspots field from 2003 2022 provide guidance for future field. Methods: We collected relevant literature on Web Science Core Collection (WoSCC) database conducted bibliometric visualization analyses using biblioshiny R-Studio VOSviewer (version 1.6.16). Results: A total 3,900 documents were retrieved WoSCC database. publications shown rapid expansion since 2011, with greatest hotspot emerging due concept "intestinal-renal syndrome," first proposed by Meijers. most journals diet metabolism, such as Nutrients. United States China influential countries, active institute was University California San Diego. Author analysis revealed that Denise Mafra, Nosratola D. Vaziri, Fouque, Denis made great contributions different aspects Clustering keywords found priorities "immunity," "inflammation," "metabolism," "urinary toxin," reflecting basis Current frontiers include "hyperuricemia," "gut microbiota," "diabetes," "trimethylamine n-oxide," "iga nephropathy," "acute injury," "chronic disease," all which necessitate further investigation. Conclusion: This presents a comprehensive offers an up-to-date outlook related axis, specific emphasis present state intercommunication gut microbiota diseases perspective may assist researchers selecting appropriate partners, help gain deeper understanding field's frontiers, thereby promoting research.
Language: Английский
Citations
12
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Nov. 20, 2023
Background Abnormal gut microbiota and blood trimethylamine-N-oxide (TMAO) metabolome have been reported in patients with type 2 diabetes mellitus (T2DM) advanced diabetic nephropathy. This study aimed to investigate the profiles a group of targeted urine metabolic characteristics T2DM or without microalbuminuria, determine correlation between composition, trimethylamine (TMA) metabolism, clinical features during progression kidney disease (DKD) Methods included 26 microalbuminuria (Micro), normoalbuminuria (Normo), 15 healthy controls (HC). Urine Fecal samples were detected using ultra performance liquid chromatography tandem mass spectrometry 16S ribosomal DNA gene sequencing, respectively. Results The TMAO/TMA ratio decreased gradually HC-Normo-Micro transition. levels TMA, choline betaine significantly different HC belonging both Normo Micro groups. At operational taxonomic unit (OTU) level, microflora diversity was reduced groups compared Taxonomic analyses revealed significant consumption relative abundances eight bacterial genera enrichment two Furthermore, six genera, namely, Ruminococcus_1, [Eubacterium]_ruminantium_group, Roseburia, Faecalibacterium, Fusicatenibacter Coprococcus_3 exhibited differences, associated elevated urinary albumin creatinine (UACR), TMAO/TMA, TMA its precursors other Conclusion imbalance has occurred early-stage DKD, short-chain fatty acid-producing bacteria accumulation UACR.
Language: Английский
Citations
11
World Journal of Nephrology, Journal Year: 2024, Volume and Issue: 13(3)
Published: Sept. 19, 2024
Inflammatory bowel disease (IBD) is a chronic condition characterized by immune-mediated inflammation in the gastrointestinal tract, which follows relapsing and remitting course. Apart from affecting IBD also has extra-intestinal manifestations (EIMs). While etiology of extraintestinal manifestation remains unclear, it theorized to be based on immunological responses influenced genetic factors. Renal involvement one EIMs observed ulcerative colitis Crohn’s disease. The renal patients encompass range conditions including nephrolithiasis, amyloidosis, tubulointerstitial nephritis, glomerulonephritis (GN), obstructive pathologies, kidney (CKD). incidence CKD varies 5%-15%. decline function can stem various factors such as direct inflammatory damage kidneys leading glomerular or tubular injury, complications like recurrent stones, GN. Additionally, nephrotoxic medications used treating IBD, TNF-α inhibitors, calcineurin aminosalicylates, exacerbate function. Currently, there lack consensus regarding these patients' screening monitoring. This review aims assess existing literature different among individuals with shedding light their pathophysiology management.
Language: Английский
Citations
4
Seminars in Nephrology, Journal Year: 2025, Volume and Issue: unknown, P. 151572 - 151572
Published: March 1, 2025
Language: Английский
Citations
0
Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(5)
Published: May 1, 2025
ABSTRACT Immunoglobulin A nephropathy (IgAN) is a primary glomerular disease characterized by the deposition of IgA. The pathogenesis it related to dysbiosis gut microbiota. Dysbiosis microbiota influences mucosal immune response and systemic system, leading glycosylation‐deficient IgA1 (Gd‐IgA1) increasing, which promotes development IgAN. Diet plays an important role in regulating treating In this review, we summarize interplay between IgAN, their underlying mechanisms. We also describe effects dietary intake on as well composition progress IgAN treatment mainly focuses inhibiting or system. Moreover, therapeutic strategies such intervention, supplement probiotics prebiotics, fecal transplantation (FMT) have shown possibility improving prognosis. Thus, exploration gut‐kidney axis, long‐term diet microbiome necessary develop more effective strategies.
Language: Английский
Citations
0