Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
29, P. 101332 - 101332
Published: Nov. 8, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
recurrent
with
an
increasing
incidence
year
by
year.
At
present,
no
safe
and
effective
treatment
for
IBD
exists.
Thus,
there
urgent
need
to
create
new
therapeutic
options
that
have
decreased
adverse
effects
positive
clinical
efficacy.
A
range
of
nanomaterials
fueled
the
advancement
nanomedicine
in
recent
years,
which
establishing
more
appealing
prospective
approaches
IBD.
However,
traditional
synthetic
still
some
problems
drug
delivery
process,
such
as
weak
targeting
ability
vectors,
difficulty
escaping
immune
surveillance,
poor
biosecurity.
Natural
sources
biological
been
identified
solve
above
problems.
system
based
on
bionic
technology
expected
achieve
breakthrough
targeted
therapy
nanotechnology
due
its
organic
integration
low
immunogenicity
natural
materials
controllability
versatility
nanocarrier
design.
We
begin
this
review
outlining
fundamental
traits
both
inflammatory
healthy
intestinal
microenvironments.
Subsequently,
we
latest
application
cell-derived
therapy.
Finally,
discuss
development
prospects
challenges
translation.
Biomimetic
nanotherapy
believed
offer
strategy
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
13(10), P. 3245 - 3269
Published: Jan. 1, 2025
This
review
discusses
ROS-responsive
nanoparticles
in
IBD
therapy,
highlighting
challenges,
solutions,
and
the
“layered
programmable
delivery”
strategy
for
enhanced
drug
delivery
localized
treatment.
The
increasing
prevalence
of
carbapenem-resistant
and
extensively
drug-resistant
Acinetobacter
baumannii
(XDR-Ab)
poses
a
critical
challenge
in
treating
hospital-acquired
pulmonary
infections.
In
this
study,
we
developed
biomimetic
neutrophil
membrane-coated
nanoparticle
system,
NM@PCN-TIG,
for
the
targeted
delivery
tigecycline
(TIG).
system
utilizes
porphyrin-based
metal-organic
framework
(MOF)
PCN-224
as
core
nanoparticle,
encapsulating
TIG
coated
with
membrane
(NM)
to
enhance
immune
evasion
targeting
infection
sites.
Its
loading
efficiency,
controlled
release
properties,
cytotoxicity,
bactericidal
activity
under
ultrasound
mediation
were
systematically
evaluated
vitro
vivo.
Our
results
demonstrated
that
NM@PCN-TIG
significantly
enhanced
efficacy
TIG,
increased
reactive
oxygen
species
(ROS)
production,
promoted
macrophage
polarization
toward
an
anti-inflammatory
phenotype.
This
innovative
nanosystem
shows
great
potential
platform
addressing
XDR-Ab-induced
pneumonia.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
12(4), P. 863 - 895
Published: Dec. 21, 2023
Illustration
shows
the
various
sources
of
cell
membrane
along
with
different
NPs
used
for
production
membrane-coated
nanoparticles
and
their
applications.
International Journal of Biochemistry & Physiology,
Journal Year:
2023,
Volume and Issue:
8(2)
Published: Jan. 1, 2023
The
safety,
compliance,
and
therapeutic
efficacy
of
pharmaceuticals
have
been
greatly
improved
in
the
last
few
years
by
notable
developments
drug
development
administration
fields.
An
overview
significant
advances
approaches
affecting
medication
distribution
is
given
this
abstract.
pharmacological
chemicals
to
humans
animals
for
purposes
known
as
delivery,
it
a
primary
area
concern.
safety-to-efficacy
ratio
approved
drugs
has
investigated
using
variety
strategies,
including
dose
titration,
monitoring,
personalized
therapy.
Furthermore,
lot
emphasis
paid
innovative
delivery
techniques
such
controlled
release,
sustained
targeted
delivery.
Even
while
conventional
methods
are
still
widely
used,
these
innovations
seek
overcome
some
its
shortcomings.
Up
forty
percent
pharmaceutical
items
on
US
market
expected
use
cutting-edge
2000.
efficient
transportation
agents
or
naturally
derived
active
compounds
their
intended
locations
treatment
various
illnesses
made
possible
recent
advancements
systems.
In
order
precisely
convey
areas,
whether
be
specific
location
regulated
release
medicinal
compounds,
state-of-the-art
technologies
must
created.
Although
strategies
showed
promise,
obstacles
need
overcome.
Asian Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
18(02)
Published: June 1, 2024
In
recent
decades,
the
utility
of
nanoformulations
as
medication
delivery
systems
has
grown.
It
is
not
always
best
option
due
to
gastrointestinal
distress,
restricted
inadequate
absorption,
and
solubility.
The
impact
early
hepatic
transit
one
biggest
obstacles
that
drugs
must
get
past
have
a
therapeutic
effect.
These
materials
attracted
lot
attention
because
studies
shown
oral
can
be
significantly
enhanced
by
controlled-release
use
nanoparticles
(NPs)
made
naturally
derived
biodegradable
polymers.
Chitosan
(CS)
several
applications
qualities
in
pharmaceutical
medical
industries.
traditional
method
been
completely
transformed
NPs'
capacity
modify
molecules
their
structures.
current
environment,
CS
small
size,
NPs
are
valuable
tool
for
novel
drug
systems.
process
ionotropic
gelation
only
used
this
field;
alternative
techniques
include
solvent
evaporation,
polyelectrolyte
complex,
emulsification
diffusion,
cross-linking,
microemulsion.
Numerous
applications,
such
found
beneficial
range
utilization,
encompassing
mucosal
controlled
administration
drugs,
tissue
engineering,
non-viral
genes,
vaccines,
ocular
electrodeposition,
target
brain,
enhancement
stability,
efficient
insulin.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
29, P. 101332 - 101332
Published: Nov. 8, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
recurrent
with
an
increasing
incidence
year
by
year.
At
present,
no
safe
and
effective
treatment
for
IBD
exists.
Thus,
there
urgent
need
to
create
new
therapeutic
options
that
have
decreased
adverse
effects
positive
clinical
efficacy.
A
range
of
nanomaterials
fueled
the
advancement
nanomedicine
in
recent
years,
which
establishing
more
appealing
prospective
approaches
IBD.
However,
traditional
synthetic
still
some
problems
drug
delivery
process,
such
as
weak
targeting
ability
vectors,
difficulty
escaping
immune
surveillance,
poor
biosecurity.
Natural
sources
biological
been
identified
solve
above
problems.
system
based
on
bionic
technology
expected
achieve
breakthrough
targeted
therapy
nanotechnology
due
its
organic
integration
low
immunogenicity
natural
materials
controllability
versatility
nanocarrier
design.
We
begin
this
review
outlining
fundamental
traits
both
inflammatory
healthy
intestinal
microenvironments.
Subsequently,
we
latest
application
cell-derived
therapy.
Finally,
discuss
development
prospects
challenges
translation.
Biomimetic
nanotherapy
believed
offer
strategy
