Trihexyphenidyl Alters Its Host’s Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

Antioxidants, Journal Year: 2023, Volume and Issue: 13(1), P. 26 - 26

Published: Dec. 21, 2023

Trihexyphenidyl (THP)—a synthetic anticholinergic medication used to manage parkinsonism and extrapyramidal symptoms—has gained significant clinical recognition. However, there is a critical gap in understanding its withdrawal effects. This study investigates the intricate interplay between gut microbiota oxidative stress during THP withdrawal. Furthermore, it explores therapeutic potential of Anacyclus pyrethrum (AEAP) for alleviating associated adverse comprehensive research combines behavioral tests, biochemical analysis, microbiome assessment utilizing matrix-assisted laser desorption ionization–time flight mass spectrometry (MALDI-TOF MS), measures. The results reveal that chronic administration leads severe syndrome, marked by heightened anxiety, depressive-like behaviors, increased cortisol levels, elevated stress, dysbiosis. AEAP alongside shows capacity mitigate these deleterious Co-treatment post-treatment with bacterial density diversity, promoting proliferation beneficial bacteria improved health. reduced levels exhibited potent antioxidant properties, effectively countering THP-induced damage. highlights effects underscores managing symptoms. findings promising impairments, reducing restoring microbiota, which could significantly impact management potentially extend other substance scenarios.

Language: Английский

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Protective Effects of Lacticaseibacillus rhamnosus IDCC3201 on Motor Functions and Anxiety Levels in a Chronic Stress Mouse Model

Food Science of Animal Resources, Journal Year: 2023, Volume and Issue: 43(6), P. 1044 - 1054

Published: Sept. 21, 2023

Growing evidence indicates a crucial role of the gut microbiota in physiological functions. Gut-brain axis imbalance has also been associated with neuropsychiatric and neurodegenerative disorders. Studies have suggested that probiotics regulate stress response alleviate mood-related symptoms. In this study, we investigated effects probiotic

Language: Английский

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The regulation of intestinal flora on host’s genes may play an essential role in the development of endometrial hyperplastic processes in yang deficiency individuals

International Journal of Clinical and Experimental Pathology, Journal Year: 2024, Volume and Issue: 17(4), P. 121 - 136

Published: Jan. 1, 2024

Yang-deficiency constitution (YADC) is linked to a higher vulnerability various diseases, such as cold coagulation and blood stasis (CCBS) syndrome infertility.Endometrial hyperplastic processes (EHPs) are leading cause of infertility in women characterized by CCBS.However, it remains unclear whether YADC related the development EHPs.Methods: We recruited 202 EHPs patients including 147 with (YEH group) 55 non-YADC (NYEH group).Fecal samples were collected from 8 YEH 3 NYEH analyzed using 16S rRNA V3-V4 sequencing for gut microbiota analysis.We obtained survey data differential dataset literature further analysis.Bioinformatics analysis was conducted microbiota-related genes public databases.Results: significantly more prevalent than (P < 0.001), suggesting potential risk factor occurrence (OR population = 13.471;OR healthy 5.173).The group had levels inflammation, estrogen, tamoxifen-related flora compared groups.There an interaction between flora, EHPs-related genes, particularly TNF gene (related inflammation) EGFR estrogen), which may play crucial role development.Conclusion: individuals exhibit significant changes their YADC.The specific host believed critical progression EHPs.

Language: Английский

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Revealing Interactions of Gut Microbiota and Metabolite in Confined Environments Using High-Throughput Sequencing and Metabolomic Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2998 - 2998

Published: Sept. 5, 2024

A confined environment is a special kind of extreme working environment, and prolonged exposure to it tends increase psychological stress trigger rhythmic disorders, emotional abnormalities other phenomena, thus seriously affecting work efficiency. However, the mechanisms through which environments affect human health remain unclear. Therefore, this study simulates strictly controlled employs integrative multi-omics techniques analyze alterations in gut microbiota metabolites workers under such conditions. The aim identify metabolic biomarkers elucidate relationship between metabolites. High-throughput sequencing results showed that significantly affects microbial composition clusters subjects’ into two enterotypes (Bla Bi). Differences abundance genera Bifidobacterium, Collinsella, Ruminococcus_gnavus_group, Faecalibacterium, Bacteroides, Prevotella Succinivibronaceae UCG-002 were significant. Untarget metabolomics analyses resulted significant intestinal increased activity body’s amino acid metabolism bile pathways. Among differed after living, four as uric beta-PHENYL-gamma-aminobutyric may be potential biomarkers. Further correlation analysis demonstrated strong association these This provides valuable reference data for improving status facilitates subsequent proposal targeted prevention treatment strategies.

Language: Английский

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Gut Microbiota as a Modulator of Post-Stress Neuroinflammation: Methodological Limitations of Existing Research Practices

Нейрохимия, Journal Year: 2024, Volume and Issue: 41(4), P. 344 - 351

Published: Dec. 22, 2024

Language: Английский

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Gut Microbiota as a Modulator of Post-Stress Neuroinflammation: Methodological Limitations of Existing Research Practices

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(4), P. 628 - 634

Published: Dec. 1, 2024

Language: Английский

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Demyelination of the amygdala mediates psychological stress-induced emotional disorders partially contributed by activation of P2X7R/NLRP3 cascade

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 124, P. 365 - 375

Published: Dec. 15, 2024

Language: Английский

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