Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice DOI Creative Commons
Meiyu Zhang, Decai Li,

Liujuan Sun

et al.

Mediators of Inflammation, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little known about regulatory effect of lung Lactobacillus and its mechanism BPD. This study explored L. reuteri on hyperoxia-induced mice injuries examined whether played a role via IL-22/STAT3 pathway. We found that intranasal administration tryptophan metabolite indole-3-aldehyde (3-IAld) ameliorated BPD-like changes, deceased proinflammatory cytokines (IL-1β, IL-6, TNF-α), increased levels surfactant-associated protein C (SPC), aquaporin 5 (AQP5), vascular endothelial growth factor receptor 2 (VEGFR2, also as FLK-1). Furthermore, 3-IAld expression IL-22. IL-22 was confirmed to ameliorate pathological protective effects could be inhibited by anti-IL-22 neutralizing antibody. Finally, we STAT3 activation MLE-12 cells. In summary, our alleviated changes activating signaling pathway production. Probiotics potential treatment for injury newborns.

Language: Английский

Hesperetin regulates the intestinal flora and inhibits the TLR4/NF-κB signaling axis to protect the blood-milk barrier and prevent mastitis DOI
Xin Ran, Guiqiu Hu, Weiwei Guo

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 342, P. 122533 - 122533

Published: Feb. 29, 2024

Language: Английский

Citations

10
Imbalance of gut microbiota is involved in the development of chronic obstructive pulmonary disease: A review DOI Open Access
Wei Song, Yuanyi Yue, Qiang Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115150 - 115150

Published: July 8, 2023

Chronic obstructive pulmonary disease (COPD) is a common chronic characterized by airway inflammation and remodeling, which seriously endangers human health. Recent developments in genomics metabolomics have revealed the roles of gut microbiota its metabolites COPD. Dysbiosis directly increases permeability, thereby promoting translocation pathological bacteria. The associated may influence development progression COPD modulating immunity inflammation. Furthermore, systemic hypoxia oxidative stress that occur also be involved intestinal dysfunction. cross-talk between lungs known as gut–lung axis; however, an overview mechanism lacking. This review highlights critical complex interplay immune responses axis, further explores possible links lungs, summarizes new interventions through diet, probiotics, vitamins, fecal transplantation, are to

Language: Английский

Citations

18
The Role of Beneficial Microbiota in COVID-19: Insights from Key Bacterial Genera DOI Creative Commons
Pabulo Henrique Rampelotto,

Clarissa Reginato Taufer,

Juliana da Silva

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1029 - 1029

Published: April 29, 2025

The COVID-19 pandemic has highlighted the need for a comprehensive understanding of factors influencing disease severity and progression. Emerging research indicates that human microbiota, particularly beneficial bacteria, significantly impacts immune responses health outcomes in patients. While existing studies provide general insights into relationship between microbiota probiotics with COVID-19, they often lack detailed exploration how specific bacterial taxa might be used as adjunctive treatments. This review aims to address this gap by focusing on ten key genera discussing their roles evaluating potential prevention treatment. covers impact these microbes health, population alterations patients, interactions other viral infections. Among microbes, several exhibit distinct patterns abundance highlighting infection dynamics. In populations Akkermansia, Ruminococcus, Roseburia are consistently reduced, while those Faecalibacterium show significant decline more severe cases. Bacteroides presents varying effects depending species involved. Alterations Blautia Lachnospiraceae associated increased inflammation severity. Likewise, depletion Lachnospira Coprococcus populations, both linked anti-inflammatory effects, may exacerbate symptom Oscillospira, though less studied, is connected overall could have implications synthesizes current highlight importance maintaining healthy alleviate contribute development novel therapeutic strategies involving modulation.

Language: Английский

Citations

0
The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19 DOI Open Access

Benita Martín-Castaño,

Patricia Diez‐Echave, Jorge García-García

et al.

Published: March 26, 2024

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity but no specific determinants of infection outcome identified yet, maybe due the complex pathogenic mechanisms. The microbiota could play key role and progression disease. Hence, SARS-CoV-2 has associated nasopharyngeal gut dysbiosis higher abundance opportunistic pathogens.To identify new prognostic markers for disease, multicenter prospective observational cohort study was carried out COVID-19 patients were divided three cohorts according their symptomatology: mild (n=24), moderate (n=51) severe/critical (n=31). Faecal samples taken analysed.Microbiota composition symptoms linear discriminant analysis genera Mycoplasma Prevotella as biomarkers samples, Allistipes , Enterococcus Escherichia faecal samples. Moreover, M. salivarium defined unique microorganism patients’ while P. bivia timonensis microbiota. A connection between also strong positive correlation (faeces) towards dentalis (nasopharyngeal) found critically ill patients.This ratio used novel biomarker patients.

Language: Английский

Citations

0
Role of Nedd4L in Macrophage Pro-Inflammatory Polarization Induced by Influenza A Virus and Lipopolysaccharide Stimulation DOI Creative Commons

Meihong Peng,

Cheng Zhao,

Lu Fangguo

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1291 - 1291

Published: June 25, 2024

Influenza A virus (IAV) infection often leads to influenza-associated fatalities, frequently compounded by subsequent bacterial infections, particularly Gram-negative co-infections. Lipopolysaccharide (LPS), a primary virulence factor in bacteria, plays crucial role influenza–bacterial However, the precise pathogenic mechanisms underlying synergistic effects of viral–bacterial co-infections remain elusive, posing significant challenges for disease management. In our study, we administered combination IAV and LPS mice examined associated parameters, including lung function, index, wet/dry ratio, serum inflammatory cytokines, Nedd4L expression tissue, mRNA levels cytokines. Co-infection with exacerbated tissue inflammation amplified M1 macrophage tissue. Additionally, stimulated macrophages vitro, assessing cytokine content cell supernatant within cells. This combined stimulation intensified response upregulated protein expression. Subsequently, used siRNA knockdown macrophages, revealing that suppression alleviated triggered concurrent stimulation. Collectively, these results highlight pivotal mediating responses observed

Language: Английский

Citations

0
Effect of Mixed Probiotics on Alleviating H1N1 Influenza Infection and Regulating Gut Microbiota DOI Creative Commons
Hongchao Wang,

Yuhao Zhao,

Zhangming Pei

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3079 - 3079

Published: Sept. 27, 2024

Influenza and other respiratory infections cause annual epidemics worldwide, with high incidence mortality rates reported among immunocompromised infants elderly individuals. Probiotics can modulate the immune system through their bacterial compositions metabolites, affecting influenza effectively responding to viral mutations. Therefore, we evaluated anti-influenza effects of mixed probiotics administered orally before after infection. The results showed that consisting Lacticaseibacillus rhamnosus CCFM1279, Limosilactobacillus reuteri CCFM1145, casei CCFM1127 inhibited replication reduced lung inflammatory damage against influenza. In addition, mixed-probiotics treatment activated systemic response host. gut microbiota analysis revealed a notable increase in abundance Alistipes Rikenella following mixed-probiotic supplementation. metabolomic indicated significant adenosine levels, which was positively correlated Parvibacter. These findings highlight effectiveness fighting viruses suggest certain metabolites may play role influencing outcomes infections.

Language: Английский

Citations

0
Detection of H1N1 Influenza Virus in the Bile of a Severe Influenza Mouse Model DOI Creative Commons
Yan Liu, Jiuyang Xu, Wei Cheng

et al.

Influenza and Other Respiratory Viruses, Journal Year: 2024, Volume and Issue: 18(10)

Published: Oct. 1, 2024

ABSTRACT Aims Influenza virus infection may lead to fatal complications including multi‐organ failure and sepsis. The influenza was detected in various extra‐pulmonary organs autopsy studies during the 2009 pandemic. However, limited research has been conducted on presence of viral particle or components peripheral blood. Methods Results We established a mouse model for severe H1N1 influenza. bile blood samples were collected over time inoculated into embryonated chicken eggs. live early infection. Immunofluorescence showed liver tissue. No isolated mice intragastrically administered with virus, indicating that spread from stream. Targeted metabolomics analysis acid tissues secondary (3‐dehydrocholic acid) decreased after Genes related fatty metabolism secretion pathways down‐regulated Conclusion Our study indicated viremia is present influenza, target organ

Language: Английский

Citations

0
Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis DOI Creative Commons

Mengyao Shi,

Qian Xue,

Jinghui Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 19, 2024

The incidence of chronic obstructive pulmonary disease (COPD) appears to be increasing and evidence suggests that the intestinal flora may play a causative role in its development. Previous studies found Shenqi Wenfei Formula (SQWF) can regulate pyroptosis via NLRP3/GSDMD pathway, thereby reducing inflammatory response lungs COPD model rats. However, there is no information on whether drug's effects are associated with flora. Therefore, this study investigates SQWF mediated through regulation flora, aiming elucidate underlying mechanisms therapeutic impact COPD.

Language: Английский

Citations

0
Potential of gut microbiota metabolites in treating COPD: network pharmacology and Mendelian randomization approaches DOI Creative Commons
Zhenghua Cao,

Shengkun Zhao,

Tong Wu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate role of in COPD through network pharmacology Mendelian randomization approaches.

Language: Английский

Citations

0
Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice DOI Creative Commons
Meiyu Zhang, Decai Li,

Liujuan Sun

et al.

Mediators of Inflammation, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little known about regulatory effect of lung Lactobacillus and its mechanism BPD. This study explored L. reuteri on hyperoxia-induced mice injuries examined whether played a role via IL-22/STAT3 pathway. We found that intranasal administration tryptophan metabolite indole-3-aldehyde (3-IAld) ameliorated BPD-like changes, deceased proinflammatory cytokines (IL-1β, IL-6, TNF-α), increased levels surfactant-associated protein C (SPC), aquaporin 5 (AQP5), vascular endothelial growth factor receptor 2 (VEGFR2, also as FLK-1). Furthermore, 3-IAld expression IL-22. IL-22 was confirmed to ameliorate pathological protective effects could be inhibited by anti-IL-22 neutralizing antibody. Finally, we STAT3 activation MLE-12 cells. In summary, our alleviated changes activating signaling pathway production. Probiotics potential treatment for injury newborns.

Language: Английский

Citations

0