Screening biomarkers for systemic lupus erythematosus based on single-cell and bulk RNA sequencing DOI Creative Commons
Meng Yang,

Di Yang,

Linquan Gan

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 25, 2023

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease. The pathogenesis of SLE remains unclear, and the aim this study was to identify novel biomarkers SLE. First, key modules cell clusters for trait sample grouping were screened by weighted gene coexpression network analysis (WGCNA). differentially expressed genes (DEGs) between normal samples in GSE72326 screened. candidate obtained overlapping DEGs, module genes, marker clusters. random forest algorithm executed based on top 5 selected as hub genes. In addition, set enrichment (GSEA) performed. Finally, expression validation, methylation analysis, immunoinfiltration completed. A total 90 DEGs control dataset. By (TNFSF13B, FCGR1A, TNFSF10, ISG15, LAP3) obtained. GSEA revealed that TNFSF13B FCGR1A involved primary immunodeficiency, cytosolic DNA sensing pathway, ribosome, LAP3 related pyruvate metabolism, complement coagulation cascade. TNFSF13B, identified SLE, which provides a new perspective Purpose : Patients methods Results Conclusion

Language: Английский

Global landscape of COVID-19 research: a visualization analysis of randomized clinical trials DOI Creative Commons
Sa’ed H. Zyoud

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 22, 2024

Abstract The emergence of COVID-19 in 2019 has resulted a significant global health crisis. Consequently, extensive research was published to understand and mitigate the disease. In particular, randomized controlled trials (RCTs) have been considered benchmark for assessing efficacy safety interventions. Hence, present study strives comprehensive overview landscape pertaining RCTs COVID-19. A bibliometric analysis performed using Scopus database. search parameters included articles from 2020 2022 keywords specifically related RCTs. data were analyzed various indicators. volume publications, contributions countries institutions, funding agencies, active journals, citation analysis, co-occurrence future direction analyzed. total 223,480 concerning published, with 3,727 them ten most productive collectively produced 75.8% documents, United States leading way by contributing 31.77%, followed UK 14.03% ( n = 523), China 12.96% 483) Canada 7.16% 267). Trials 173, 4.64%), BMJ Open 81, 2.17%), PLOS One 73, 1.96%) JAMA Network 53, 1.42%) journals publishing identified four clusters areas: effectiveness vaccines, mental strategies cope impact pandemic, use monoclonal antibodies treat patients COVID-19, systematic reviews meta-analyses research. This paper offers detailed examination environment their context pandemic. body findings found generated collaborative efforts multiple countries, organizations. predominant areas encompassed health, antibodies, reviews. information potential aid researchers, policymakers, funders discerning weakness establishing priority.

Language: Английский

Citations

6
A bibliometric analysis of the global impact of metaproteomics research DOI Creative Commons

AbdulAziz Ascandari,

Suleiman Aminu,

Nour El Houda Safdi

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 5, 2023

Metaproteomics is a subfield in meta-omics that used to characterize the proteome of microbial community. Despite its importance and plethora publications different research area, scientists struggle fully comprehend functional impact on study microbiomes. In this study, bibliometric analyses are evaluate current state metaproteomic globally as well specific contribution Africa burgeoning area. we use globally, identify frontiers hotspots, further predict future trends metaproteomics. The area was evaluated.Relevant documents from 2004 2022 were extracted Scopus database. subjected visualization using VOS viewer Biblioshiny package R. Factors such publication, country institutional cooperation networks, leading scientific journals, author's productivity, keywords conducted. African ranked Field-Weighted Citation Impact (FWCI) scores.A total 1,138 included number increased drastically with more (170) reported 2021. terms publishers, Frontiers Microbiology had highest (62). United States America (USA), Germany, China, Canada, together other European countries most productive. Institution-wise, Helmholtz Zentrum für Umweltforschung, Germany while Max Plank Institute collaborative link strength. Jehmlich N. productive author whereas Hettich RL h-index 63. Regarding Africa, only 2.2% overall continent publication outputs South Africa. More than half an FWCI score ≥ 1.The metaproteomics rapidly evolving developed way. Although showed prospects for progress, could be accelerated by providing funding, collaborations, mentorship programs.

Language: Английский

Citations

11
The impact of gut microbiome on immune and metabolic homeostasis in type 1 diabetes: Clinical insights for prevention and treatment strategies DOI
Jiaqi Li, Zhiguo Xie,

Lin Yang

et al.

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 151, P. 103371 - 103371

Published: Jan. 29, 2025

Language: Английский

Citations

0
A scientometric visualization analysis of the gut microbiota and gestational diabetes mellitus DOI Creative Commons

Zehao Su,

Lina Liu, Jian Zhang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Background The prevalence of gestational diabetes mellitus (GDM), a condition that is widespread globally, increasing. relationship between the gut microbiota and GDM has been subject research for nearly two decades, yet there no bibliometric analysis this correlation. This study aimed to use bibliometrics explore GDM, highlighting emerging trends current hotspots in field. Results A total 394 papers were included analysis. China emerged as preeminent nation terms number publications on subject, with 128 (32.49%), whereas United States had most significant impact, 4,874 citations. University Queensland prolific institution, contributing 18 publications. Marloes Dekker Nitert was active author 16 publications, Omry Koren garnered citations, totaling 154. journal Nutrients published studies (28 7.11%), PLoS One commonly co-cited journal, 805 With respect keywords, focuses can be divided into 4 clusters, namely, “the interrelationship pregnancy, childbirth,” adverse metabolic outcomes GDM,” composition mechanisms” “microbiota ecological imbalance.” Key areas focus include interactions individuals well formation inheritance microbiota. Increasing attention given impact probiotic supplementation metabolism pregnancy patients. Moreover, ongoing exploring potential biomarker GDM. These topics represent both future directions Conclusion provides comprehensive knowledge map highlights key areas, outlines directions.

Language: Английский

Citations

0
Analyzing global research trends and focal points in the utilization of laser techniques for the treatment of urolithiasis from 1978 to 2022: visualization and bibliometric analysis DOI
Faris Abushamma, Sa’ed H. Zyoud

Urolithiasis, Journal Year: 2024, Volume and Issue: 52(1)

Published: April 17, 2024

Language: Английский

Citations

3
Research prospects for kidney xenotransplantation: a bibliometric analysis DOI Creative Commons
Shujun Yang, Mingtao Zhang, Wei Hao

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: Feb. 23, 2024

Background Xenograft kidney transplantation has been receiving increasing attention. The purpose of this study is to use bibliometric analysis identify papers in research field and explore their current status development trends.

Language: Английский

Citations

2
Gut microbiota and autism spectrum disorders: where do we stand? DOI Creative Commons
Sa’ed H. Zyoud,

Muna Shakhshir,

Amani S. Abushanab

et al.

Gut Pathogens, Journal Year: 2023, Volume and Issue: 15(1)

Published: Oct. 25, 2023

Children with autism spectrum disorder (ASD) often have digestive problems and microbial imbalances in their guts, suggesting that these conditions may play a role the development of disorder. Scopus-based research on gut microbiota ASD was examined this bibliometric analysis to shed light current state identify potential hotspots for future work area.We searched documents from Scopus database reference citation collect published data 2003 2022. The downloaded document records were exported VOSviewer v.1.6.19 examine visualize collaboration between countries determine hotspots.The search yielded 958 articles specifically dedicated ASD. number publications field increased rapidly after 2013, peak United States (n = 267; 27.87%) most active country, followed by China 171; 17.85%) Italy 96; 10.02). International observed, USA playing central role. University College Cork, Ireland, productive institution 24; 2.51%). National Natural Science Foundation funding agency 76; 7.93%). Nutrients journal had highest 28; 2.92%). related highly cited, an h-index 108. themes identified focused modulation as therapy children gut-brain axis dysfunction ASD.In recent years, study its association has garnered considerable interest emergent study. results substantially enhance our understanding knowledge landscape illuminate avenues research. It is essential emphasize significance devoting more resources newest promising areas, such investigating therapeutic benefits modulating intestinal This enormous merits intensified focus investigation.

Language: Английский

Citations

6
Unveiling the hidden world of gut health: Exploring cutting-edge research through visualizing randomized controlled trials on the gut microbiota DOI Open Access
Sa’ed H. Zyoud,

Muna Shakhshir,

Amani S. Abushanab

et al.

World Journal of Clinical Cases, Journal Year: 2023, Volume and Issue: 11(26), P. 6132 - 6146

Published: Sept. 8, 2023

The gut microbiota plays a crucial role in gastrointestinal and overall health. Randomized clinical trials (RCTs) play advancing our knowledge evaluating the efficacy of therapeutic interventions targeting microbiota.To conduct comprehensive bibliometric analysis literature on RCTs involving microbiota.Using tools, descriptive cross-sectional investigation was conducted scholarly publications concentrated related to microbiota, spanning years 2003 2022. study used VOSviewer version 1.6.9 examine collaboration networks between different countries evaluate frequently employed terms titles abstracts retrieved publications. primary objective this identify key research areas focal points associated with microbiota.A total 1061 relevant articles were identified from 24758 published number showed notable increase over time, positive correlation (R2 = 0.978, P < 0.001). China (n 276, 26.01%), United States 254, 23.94%), Kingdom 97, 9.14%) leading contributing countries. Københavns Universitet 38, 3.58%) Dankook University 35, 3.30%) top active institutions. co-occurrence shows current trends important topics, such as obesity safety fecal transplantation, effects dietary humans.The highlights rapid growth importance that involve microbiota. This provides valuable insight into trends, identifies players, outlines potential future directions field. Additionally, topics critical advancement science provided insights

Language: Английский

Citations

5
Bibliometric analysis of global research trends between gut microbiota and pancreatic cancer: from 2004 to 2023 DOI Creative Commons
Shuang Wu, Wen Su,

Kangli An

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 27, 2023

Background Pancreatic cancer (PC) is one of the most lethal malignancies digestive system and expected to be second leading cause cancer-related death in United States by 2030. A growing body evidence suggests that gut microbiota (GM) intimately involved clinical diagnosis, oncogenic mechanism treatment PC. However, no bibliometric analysis PC GM has been reported. Methods The literature on was retrieved from Web Science Core Collection (WoSCC) database for period January 1, 2004 April 25, 2023. Microsoft Excel 2021, CiteSpace, VOSviewer, Scimago Graphica, Graphpad Prism, Origin, R package “bibliometrics” online program were used visualize publishing trends hot spots this field. Results total 1,449 articles included, including 918 531 reviews. Publishing had grown rapidly since 2017, with 2023 publish 268 articles. Unsurprisingly, ranked highest terms number literatures, H index average citations. University California System active institution, but Harvard tended cited average. three influential researchers Robert M. Hoffman, Zhao Minglei, Zhang Yong. Cancers published papers, while Nature journal. Keyword theme indicated “tumor microenvironment,” “gemcitabine-resistance,” “ductal adenocarcinoma,” “gut microbiota” “diagnosis” will hotspots frontiers research future. Conclusion In summary, field receiving increasing attention. We found future PC/GM may focus oncogenesis, flora combination therapy exploitation new predictive biomarkers, which provides effective suggestions insights scholars.

Language: Английский

Citations

5
Structural and temporal dynamics analysis of neural circuit from 2002 to 2022: A bibliometric analysis DOI Creative Commons
Yuan Liu, Wei Lin, Jie Liu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24649 - e24649

Published: Jan. 1, 2024

In the pursuit of causal insights into neural circuit functionality, various interventions, including electrical, genetic, and pharmacological approaches, have been applied over recent decades. This study employs a comprehensive bibliometric perspective to explore field circuits.

Language: Английский

Citations

0