This
research,
drawing
from
the
UK
Biobank
and
encompassing
115,078
participants,
harnessed
instrumental
variables
metabolomic
quantitative
trait
loci
studies
to
probe
influence
of
plasma
metabolites
on
Inflammatory
Bowel
Disease
(IBD).
High-throughput
nuclear
magnetic
resonance
(NMR)
was
employed
non-fasting
baseline
EDTA
samples
measure
metabolic
biomarkers.
The
study
utilized
a
specific
GWAS
dataset
for
IBD
identified
as
ebi-a-GCST90038684,
selected
41
inflammatory
factors
exposure
variables.
Using
conventional
genome-wide
significance
thresholds,
SNPs
related
biomarkers
were
chosen,
statistical
tools
like
linkage
disequilibrium
(LD)
clumping
inverse
variance
weighted
(IVW)
method
applied
precise
analyses.
All
evaluations
performed
R
platform
using
various
packages.
Notably,
Acetone,
Glucose,
Interleukin-2
receptor
antagonist
levels
demonstrated
significant
causal
relationship
with
IBD,
an
OR
1.001
95%
CI
1.0004-1.002,
p=0.002.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 22, 2024
Pyroptosis
is
an
innate
immune
response
triggered
by
the
activation
of
inflammasomes
various
influencing
factors,
characterized
cell
destruction.
It
impacts
system
and
cancer
immunotherapy.
In
recent
years,
roles
pyroptosis
in
intestinal
inflammation
have
been
continuously
confirmed.
This
article
reviews
latest
progress
mechanisms,
new
discoveries
inflammasomes,
mutual
regulation
between
their
applications
diseases.
Additionally,
potential
synergistic
treatment
mechanisms
diseases
with
are
summarized,
challenges
future
directions
discussed,
providing
ideas
for
therapy.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 8, 2024
In
the
advancement
of
Inflammatory
Bowel
Disease
(IBD)
treatment,
existing
therapeutic
methods
exhibit
limitations;
they
do
not
offer
a
complete
cure
for
IBD
and
can
trigger
adverse
side
effects.
Consequently,
exploration
novel
therapies
multifaceted
treatment
strategies
provides
patients
with
broader
range
options.
Within
framework
IBD,
gut
microbiota
plays
pivotal
role
in
disease
onset
through
diverse
mechanisms.
Bacteriophages,
as
natural
microbial
regulators,
demonstrate
remarkable
specificity
by
accurately
identifying
eliminating
specific
pathogens,
thus
holding
promise.
Although
clinical
trials
have
affirmed
safety
phage
therapy,
its
efficacy
is
prone
to
external
influences
during
storage
transport,
which
may
affect
infectivity
regulatory
roles
within
microbiota.
Improving
stability
precise
dosage
control
bacteriophages—ensuring
robustness
consistent
dosing,
targeted
delivery
infection
sites—is
crucial.
This
review
thoroughly
explores
latest
developments
inherent
challenges,
focusing
on
interaction
between
bacteriophages.
It
highlights
bacteriophages’
potential
microbiome
modulators
offering
detailed
insights
into
research
bacteriophage
encapsulation
Particular
attention
paid
functionality
various
carrier
systems,
especially
regarding
their
protective
properties
ability
colon-specific
delivery.
aims
provide
theoretical
foundation
using
bacteriophages
paving
way
enhanced
regulation
intestinal
Cells,
Journal Year:
2023,
Volume and Issue:
12(22), P. 2654 - 2654
Published: Nov. 19, 2023
Inflammatory
bowel
diseases
(IBDs)
are
characterized
by
a
persistent
low-grade
inflammation
that
leads
to
an
increased
risk
of
colorectal
cancer
(CRC)
development.
Several
factors
implicated
in
this
pathogenetic
pathway,
such
as
innate
and
adaptive
immunity,
gut
microbiota,
environment,
xenobiotics.
At
the
mucosa
level,
complex
interplay
between
immune
system
microbiota
occurs;
disequilibrium
these
two
alteration
permeability,
called
‘leaky
gut’.
Subsequently,
activation
several
inflammatory
pathways
composition
with
proliferation
pro-inflammatory
bacteria,
known
‘pathobionts’,
take
place,
leading
further
increase
inflammation.
This
narrative
review
provides
overview
on
principal
Pattern
Recognition
Receptors
(PRRs),
including
Toll-like
receptors
(TLRs)
NOD-like
(NLRs),
focusing
their
recognition
mechanisms,
signaling
pathways,
contributions
responses.
We
also
report
genetic
polymorphisms
TLRs
dysregulation
NLR
can
influence
regulation
contribute
development
progression
disease
cancer.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6416 - 6416
Published: June 11, 2024
Inflammatory
Bowel
Disease
(IBD)
is
a
complex
and
challenging
health
problem
that
exerts
significant
impact
on
the
quality
of
life
millions
individuals
worldwide
[...]
The American Journal of Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 33
Published: Nov. 25, 2024
Acupuncture
and
moxibustion
are
widely
acknowledged
as
effective
complementary
therapies
for
managing
inflammatory
bowel
disease
(IBD)
in
traditional
Chinese
medicine.
However,
the
regulatory
mechanisms
by
which
these
two
exert
their
therapeutic
effects
IBD
yet
to
be
fully
elucidated.
The
objective
of
this
study
was
investigate
action
underlying
acupuncture
regulative
differences
between
them
interventions
IBD.
Using
a
dextran
sodium
sulfate-induced
mice
model,
treatments
were
evaluated
examination
body
weight,
stool
samples,
colon
morphology,
factors,
gut
microbiota,
metabolites.
results
indicated
that
both
mitigated
weight
reduction;
improved
structural
characteristics
intestinal
tissues;
increased
levels
anti-inflammatory
cytokines
including
interleukin
(IL)-10;
decreased
pro-inflammatory
cytokines,
tumor
necrosis
factor-alpha
(TNF-[Formula:
see
text]),
nuclear
factor
kappa
B
(NF-[Formula:
text]B),
IL-6,
IL-1[Formula:
text],
IL-17.
had
distinct
on
regulation
microbiota
metabolic
pathways
mice.
Moxibustion
regulated
greater
number
than
acupuncture,
majority
associated
with
amino
acid
metabolism,
brain
signal
transmission,
energy
pathways.
These
findings
provide
scientific
basis
differential
applications
clinical
practice.
Expert Review of Proteomics,
Journal Year:
2023,
Volume and Issue:
20(12), P. 397 - 418
Published: Nov. 7, 2023
Introduction
An
increasing
number
of
studies
indicate
that
the
microbiota-gut-brain
axis
is
an
important
pathway
involved
in
onset
and
progression
depression.
The
responses
organism
(or
its
microorganisms)
to
external
cues
cannot
be
separated
from
a
key
intermediate
element:
their
metabolites.
