Role of a Whole Plant Foods Diet in Breast Cancer Prevention and Survival

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Jan. 9, 2025

Breast cancer (BC) is one of the leading causes death and morbidity among women worldwide. Epidemiologic evidence shows that risk BC other chronic diseases decreases as proportion whole plant foods increases, while animal (fish, meat, poultry, eggs, seafood, dairy products) non–whole (e.g., refined grains, added sugars, French fries) in diet decreases. Whole include fruits, vegetables, roots, tubers, legumes, nuts, seeds from which no edible part has been removed to food added. A lowers insulin resistance, inflammation, excess body fat, cholesterol, insulin-like growth factor 1 sex hormone bioavailability; it also increases estrogen excretion, induces favorable changes gut microbiota, may favorably affect mammary microbiota composition decrease early menarche, all contributing reduced incidence, recurrence, mortality. This review explores connection between a mortality well potential mechanisms involved. Additionally, this compared with dietary approaches recommended for BC. seems optimal pattern overall disease prevention exclusively consists which, based on existing evidence, lead best health outcomes.

Language: Английский

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Investigating the role of inflammatory cytokines in mediating the effect of gut microbiota on gastrointestinal cancers: a mendelian randomization study

Gastric Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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The Genomic and Biologic Landscapes of Breast Cancer and Racial Differences

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13165 - 13165

Published: Dec. 7, 2024

Breast cancer is a significant health challenge worldwide and the most frequently diagnosed among women globally. This review provides comprehensive overview of breast biology, genomics, microbial dysbiosis, focusing on its various subtypes racial differences. primarily classified into carcinomas sarcomas, with constituting cases. Epidemiology risk factors are important for public intervention. Staging grading, based TNM Nottingham grading systems, respectively, crucial to determining clinical outcome treatment decisions. Histopathological include in situ invasive carcinomas, such as ductal carcinoma (IDC) lobular (ILC). The explores molecular subtypes, including Luminal A, B, Basal-like (Triple Negative), HER2-enriched, delves cancer's histological progression patterns. Recent research findings related nuclear mitochondrial genetic alterations, epigenetic reprogramming, role microbiome dysbiosis differences also reported. an update current diagnostics modalities.

Language: Английский

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Gut microbiota in women: The secret of psychological and physical well-being

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(45), P. 5945 - 5952

Published: Dec. 1, 2023

The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence revealed influence of on other organs such as central nervous system, cardiovascular endocrine-metabolic systems digestive system. study is outlining new broader frontiers every day holds enormous innovation potential for medical pharmaceutical fields. Prevention treatment specific women's diseases involves need deepen function a junction organ where certain positive bacteria can be very beneficial unique dynamic at same time, subject external factors that change it, capable modulating itself different stages woman's life, playing an important role arises from intertwining biological mechanisms between female genital could play key personalized medicine.

Language: Английский

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Microbiome's Universe: Impact on health, disease and cancer treatment

Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 392, P. 161 - 179

Published: July 14, 2024

Language: Английский

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Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors

Expert Review of Molecular Diagnostics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Standard clinical parameters like tumorsize, age, lymph node status, and molecular markers are used to predictprogression risk treatment response. However, exploring additional markersthat reflect underlying biology could offer a more comprehensive understandingof the tumor microenvironment (TME). The TME influences development,progression, disease severity, survival, with tumor-associated bacteriaposited play significant roles. Studies on microbiota havefocused high bacterial-load sites such as gut, oral cavity, stomach,but interest is growing in non-gastrointestinal (GI) solid tumors, asbreast, lung, pancreas. Microbe-based biomarkers, including Helicobacter pylori, humanpapillomavirus (HPV), hepatitis B C viruses, have proven valuable inpredicting gastric, cervical, renal cancers. Potential of prognostic andpredictive bacterial biomarkers non-GI tumors methodologiesused. Advances techniques 16SrRNA gene sequencing, qPCR, immunostaining, situ hybridization enabled detailed analysis ofdifficult-to-culture microbes tumors. ensure reliableresults, it critical standardize protocols, accurately align reads,address contamination, maintain proper sample handling. This will pave theway for developing reliable that enhance prognosis,prediction, personalized planning.

Language: Английский

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Intestinal flora was associated with occurrence risk of chronic non-communicable diseases

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(11)

Published: March 12, 2025

BACKGROUND The intestinal flora (IF) has been linked to risks of non-communicable diseases, especially various cancers, stroke, and Alzheimer’s disease. However, many uncertainties these associations during different stages growth, development, aging still exist. Therefore, further in-depth explorations are warranted. AIM To explore the human IF with disease achieve more accurate convincing conclusions. METHODS Cohort, cross-sectional, case-control, Mendelian randomization studies published in PubMed Web Science databases until December 31, 2023 were systematically reviewed clarify at genus level which grouped accordance 10th revision International Classification Diseases. RESULTS In total, 57 included quantitatively examine influence on 30 diseases aging. Population confirmed positive abundances Bifidobacterium Ruminococcus multiple sclerosis. CONCLUSION These findings contribute a deeper understanding roles provide novel evidence for effective strategies prevention treatment diseases. future, it will be necessary greater variety research techniques uncover specific mechanisms by gut microbiota trigger conduct temporal relationship between alterations so as causal accurately.

Language: Английский

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Gut microbiota’s causative relationship with peripheral artery disease: a Mendelian randomization study

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 5, 2024

Introduction The relationship between gut microbiota and peripheral artery disease (PAD) remains understudied. While traditional risk factors like smoking hyperlipidemia are well-understood, our study aims to determine the potential causative association of with PAD using Mendelian Randomization. Methods Data from International MiBioGen Consortium FinnGen research project were used 211 bacterial taxa. Instrumental variables, comprising 2079 SNPs, selected based on significance levels linkage disequilibrium. Analyses conducted utilizing inverse-variance weighted (IVW) method other statistical MR techniques mitigate biases, processed in R (v4.3.1) TwosampleMR package. Results Three taxa, namely genus Coprococcus2 , RuminococcaceaeUCG004 RuminococcaceaeUCG010 emerged as protective against PAD. In contrast, family. FamilyXI Lachnoclostridium LachnospiraceaeUCG001 identified factors. Conclusion Our findings hint at a certain PAD, introducing new avenues for understanding PAD’s etiology developing effective treatments. observed associations now warrant further validation varied populations detailed exploration finer taxonomic levels.

Language: Английский

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Mendelian randomization suggests causal correlations between inflammatory cytokines and immune cells with mastitis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 27, 2024

Objectives Previous studies have reported that immunoinflammatory responses associations with mastitis. Here, we aimed to further figure out whether circulating inflammatory cytokines and immune cells causally impact mastitis liability. Methods The two-sample Mendelian randomization made use of genetic variances 91 from a large publicly available genome-wide association study (GWAS) containing 14,824 participants, 731 immunophenotypes data 3,757 individuals as exposures separately, GWAS summary (1880 cases 211699 controls European ancestry) outcome. primary analysis applied the inverse-variance weighted (IVW) method estimate causal influences, MR-Egger, median, mode simple supplementary approaches. Heterogeneity pleiotropy were evaluated by Cochrane Q test, MR-Egger intercept MR-PRESSO global test. Results results indicated CX3CL1 may be suggestively relevant risk (odds ratio, OR = 1.434, 95% CI 1.142~1.800, p 0.002). Moreover, three identified having potential link ( < 0.05). Significantly, CD28- CD8dim %CD8dim (OR 1.058, 1.024 ~ 1.093, 0.0006) CD45 on CD33br HLA DR+ 1.097, 1.039 1.157, 0.0008) found induce possibly. Conversely, CD39+ secreting Treg AC 0.929, 0.884~ 0.978, 0.005) pertained protective factors Cochran’s test no significant heterogeneity > 0.05) or 0.05), supporting robustness reliability our findings. Conclusion Our adds current knowledge roles means, thus guiding future clinical research.

Language: Английский

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Metabolites in the Dance: Deciphering Gut-Microbiota-Mediated Metabolic Reprogramming of the Breast Tumor Microenvironment

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4132 - 4132

Published: Dec. 11, 2024

Breast cancer (BC), a major cause of death among women worldwide, has traditionally been linked to genetic and environmental factors. However, emerging research highlights the gut microbiome’s significant role in shaping BC development, progression, treatment outcomes. This review explores intricate relationship between microbiota breast tumor microenvironment, emphasizing how these microbes influence immune responses, inflammation, metabolic pathways. Certain bacterial species either contribute or hinder progression by producing metabolites that affect hormone metabolism, system pathways, cellular signaling. An imbalance bacteria, known as dysbiosis, associated with heightened risk BC, like short-chain fatty acids (SCFAs) enzymes such β-glucuronidase playing key roles this process. Additionally, can impact effectiveness chemotherapy, certain bacteria degrade drugs gemcitabine irinotecan, leading reduced efficacy. Understanding complex interactions may pave way for innovative approaches, including personalized microbiome-targeted therapies, probiotics fecal transplants, offering new hope more effective prevention, diagnosis, BC.

Language: Английский

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