Microbiome Research Reports, Journal Year: 2024, Volume and Issue: 3(4)
Published: Sept. 10, 2024
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Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 237 - 255
Published: March 21, 2024
This review aims to argue how using probiotics can improve anxiety and depressive behaviour without adverse effects, also exploring the impact of postbiotics on it. Specifically, have drawn more attention as effective alternative treatments, considering rising cost antidepressant anti-anxiety drugs high risk side effects. Depression disorders are among most common mental illnesses in world's population, characterised by low mood, poor general interest, cognitive or motor dysfunction. Thus, this study analyzed published literature anxiety, depression, probiotic supplementation from PubMed Scopus, focusing last twenty years. focused effect health they because their extensive clinical applications positive various diseases. Numerous studies demonstrated gut microbiota might be critical for mood regulation affect host regulating gut-brain axis. By comparing different works analysed, it was possible identify a strategy which selected employed and, at same time, assess optimised postbiotics, an innovation well-being humans.
Language: Английский
Citations
17
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(4), P. 391 - 391
Published: April 6, 2024
The prevalence of schizophrenia, affecting approximately 1% the global population, underscores urgency for innovative therapeutic strategies. Recent insights into role neuroinflammation, gut–brain axis, and microbiota in schizophrenia pathogenesis have paved way exploration psychobiotics as a novel treatment avenue. These interventions, targeting gut microbiome, offer promising approach to ameliorating psychiatric symptoms. Furthermore, advancements artificial intelligence nanotechnology are set revolutionize psychobiotic development application, enhance their production, precision, effectiveness. This interdisciplinary heralds new era management, potentially transforming patient outcomes offering beacon hope those afflicted by this complex disorder.
Language: Английский
Citations
15
Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1352 - 1352
Published: April 30, 2024
In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed examine the efficacy psychobiotics—probiotics beneficial mental health via gut–brain axis—in adults with psychiatric and cognitive disorders. Out 51 studies involving 3353 patients where half received psychobiotics, there notably high measurement effectiveness specifically in treatment depression symptoms. Most participants were older female, treatments commonly utilizing strains Lactobacillus Bifidobacteria over periods ranging 4 24 weeks. Although general agreement on variability approaches presentations limits comparability generalization findings. This underscores need for more personalized optimization deeper investigation into mechanisms through which psychobiotics act. The research corroborates therapeutic potential represents progress management
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5782 - 5782
Published: May 26, 2024
Nowadays, depressive disorder is spreading rapidly all over the world. Therefore, attention to studies of pathogenesis disease in order find novel ways early diagnosis and treatment increasing among scientific medical communities. Special drawn a biomarker therapeutic strategy through microbiota–gut–brain axis. It known that symbiotic interactions between gut microbes host can affect mental health. The review analyzes mechanisms action microbiota on pathophysiology depression. possibility using knowledge about taxonomic composition metabolic profile patients with depression select gene compositions (metagenomic signature) as biomarkers evaluated. use silico technologies (machine learning) for based given. Alternative approaches are being considered by balancing microbial dietary modifications additives, namely probiotics, postbiotics (including vesicles) prebiotics psychobiotics, fecal transplantation. bacterium Faecalibacterium prausnitzii under consideration promising new-generation probiotic auxiliary diagnostic analysis conducted this may be useful clinical practice pharmacology.
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5377 - 5377
Published: May 15, 2024
In recent years, there has been a growing interest in the concept of “gut–brain axis”. addition to well-studied diseases associated with an imbalance gut microbiota, such as cancer, chronic inflammation, and cardiovascular diseases, research is now exploring potential role microbial dysbiosis onset development brain-related diseases. When function intestinal barrier altered by dysbiosis, aberrant immune system response interacts nervous system, leading state “neuroinflammation”. The microbiota–brain axis mediated inflammatory immunological mechanisms, neurotransmitters, neuroendocrine pathways. This narrative review aims illustrate molecular basis neuroinflammation elaborate on gut–brain virtue analyzing various metabolites produced microbiome how they might impact system. Additionally, current will highlight sex influences these mechanisms. fact, hormones brain–gut microbiota at different levels, central enteric one, enteroendocrine cells. A deeper understanding human health disease crucial guide diagnoses, treatments, preventive interventions.
Language: Английский
Citations
4
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20
Published: Feb. 5, 2025
Psychobiotics are live microorganisms that, when administered in adequate amounts, confer mental health benefits to the host. Several clinical studies have demonstrated significant from psychobiotic administration, making them an emerging topic food science. Certain strains of Lactobacillus, Bifidobacterium, Streptococcus, Escherichia, and Enterococcus species known for their ability modulate gut-brain axis provide benefits. Proposed action mechanisms include production neuroactive compounds or precursors, which may cross blood-brain barrier, transported by extracellular vesicles. However, there is a lack vivo evidence directly confirming these mechanisms, although indirect recent suggest potential pathways further investigation. To advance our understanding, it crucial study within host, with accurate quantification and/or precursors being key such studies. Current methods, however, face challenges, as low sensitivity detecting trace metabolites limited specificity due interference other compounds, impacting reliability measurements. This review discusses field psychobiotics, compound estimation techniques, perspectives improvement quantifying
Language: Английский
Citations
0
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: May 1, 2025
Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under selective pressures nature, reflecting intricate and adaptive processes evolution. The microbiota residing in various regions human body has numerous roles different physiological such as nutrition, metabolism, immune regulation, etc. In zeal achieving empirical insights into ambit gut microbiome, research over years led to revelation reciprocal interaction between microbiome cognitive functioning body. Dysbiosis microbial composition disturbs homeostatic This dysbiosis been associated with chronic diseases, including brain cancer, glioma, glioblastoma, review explores mechanistic role dysbiosis-mediated progression cancers their subtypes. Moreover, it demonstrates regulatory metabolites produced by microbiota, short-chain fatty acids, amino lipids, etc., tumour progression. Further, we also provide valuable mediating efficiency therapeutic regimens, thereby leveraging potential biomarkers targets for improved treatment outcomes.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 471 - 471
Published: Feb. 26, 2024
Injurious behaviors (i.e., aggressive pecking, feather and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress related health welfare issues as well economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation neuropsychiatric disorders via microbiota-gut-brain axis, consequently increasing frequency intensity of aggression violent behaviors. Restoration imbalanced microbial composition has become novel treatment strategy for mental illnesses, such depression, anxiety, bipolar disorder, schizophrenia, impulsivity, compulsivity. A similar function modulating following challenge may be present egg-laying chickens. The avian cecum, multi-purpose organ, greatest bacterial biodiversity (bacterial diversity, richness, species composition) along gastrointestinal tract, with vitally important functions maintaining physiological behavioral homeostasis, especially during periods stress. To identify effects microbiome on injurious chickens, we have designed tested transferring cecal contents from two divergently selected inbred chicken lines stress-related recipient chicks commercial layer strain. This article reports outcomes multi-year study modification microbiota reduce An discovery this corpus experiments is that chickens can reduced or inhibited through modifying brain serotonergic activities gut-brain without donor-recipient genetic effects.
Language: Английский
Citations
3
Food Science of Animal Resources, Journal Year: 2024, Volume and Issue: 44(6), P. 1252 - 1265
Published: Oct. 2, 2024
As consumers become more interested in healthier lifestyles, the global functional food market is expanding. Probiotics have gained attention because of their numerous health benefits to host and may even treat various pathological conditions. interact with cells, particularly, probiotics-derived extracellular vesicles (PEVs) are key factors probiotics. Additionally, nano-scaled lipid-bilayer particles that carry biological molecules, indicating potential as new postbiotics can provide same probiotics while complementing side effects associated The importance mental care becoming increasingly prominent considering societal conditions, such recent aging population coronavirus disease 2019 pandemic. However, response issues among modern individuals insufficient, there a need for development personalized treatments overcome limitations current therapies. PEVs physiological functions, including mediating cellular communication central nervous system, which indicates associations disorders. Therefore, we focused on beneficial brain health. Recent research has shown adjust expression brain-derived neurotrophic
Language: Английский
Citations
1
International Journal Of Pharmaceutical Research And Allied Sciences, Journal Year: 2024, Volume and Issue: 13(1), P. 18 - 25
Published: Jan. 1, 2024
The field of psychology has advanced over the years in treating psychiatric disorders such as major depressive disorder (MDD), Schizophrenia, and Alzheimer's disease (AD). Depression or clinical depression is a mental health issue characterized by chronic sadness, hopelessness, emptiness, which diminishes patient's quality life. According to WHO, an estimated 3.8% world's population experience depression, 15% depressed patients eventually die su
Language: Английский
Citations
0