Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism

Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 12, 2024

Abstract There is increasing evidence that probiotic and commensal bacteria play a role in substrate metabolism, energy harvesting intestinal homeostasis, may exert immunomodulatory activities on human health. In addition, recent research suggests these microorganisms interact with vitamins minerals, promoting metabolic well-being while producing vital microbial metabolites such as short-chain fatty acids (SCFAs). this regard, there flourishing field exploring the intricate dynamics between vitamins, SCFAs, commensal/probiotic interactions. review, we summarize some of major hypotheses beyond mechanisms by which commensals/probiotics impact gut health their additional effects absorption metabolism SCFAs. Our analysis includes comprehensive review existing from preclinical clinical studies, particular focus potential interaction micronutrients. Finally, highlight knowledge gaps outline directions for future evolving field.

Language: Английский

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Effect of Lactiplantibacillus plantarum on the growth, hemato-biochemical, inflammation, apoptosis, oxidative stress markers, involved gens and histopathological alterations in growing rabbits challenged with aflatoxin B1

Poultry Science, Journal Year: 2024, Volume and Issue: 103(9), P. 104002 - 104002

Published: June 22, 2024

Aflatoxin B1 (AFB1) is a significant pollutant found in food and feed, posing threat to public health. The objective of this study was assess the effect Lactiplantibacillus plantarum (LACP) against AFB1 growing rabbits by investigating growth, serum metabolites, immunity, antioxidant capacity, inflammatory response. A total 60 male (721.5±2.68g) were allocated four experimental groups. control group receiving only basal diet, (0.3 mg AFB1/kg diet), LACP (1×109 cfu/g /kg combination + 0.3 diet; AFB1+ LACP) for eight weeks. administration alone significantly decreased final body weight, gain, feed intake, while increasing conversion ratio (P<0.05). decline proteins globulins, along with elevated levels hepatic enzymes (AST, ALP, ALT, GGT) renal function markers (creatinine uric acid), observed AFB1-contaminated Immunoglobulins (IgG IgM) decreased, alongside elevation triglycerides, direct bilirubin, indirect bilirubin fed diets Supplementing diet restored growth reduction, improved liver kidney acid) functions, enhanced immune rabbit Antioxidant indices (SOD, GSH, CAT) However, addition capacity malondialdehyde (MDA) protein carbonylation (PC) tissues Serum interlukin-4 (IL-4) interferon gamma (IFN‐γ) increased (P<0.05), but reversed elevation. downregulated expression immune-inflammatory genes such Nrf2, IL-10, BCL-2 genes, up-regulating caspase-3 (CASP3) gene (Nrf2, BCL-2) reduced apoptotic-related CASP3. This highlights potential L. diet) as protective agent enhancing reducing apoptosis inflammation pathways.

Language: Английский

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Biodegradation of chemical contamination by lactic acid bacteria: A biological tool for food safety

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140732 - 140732

Published: Aug. 2, 2024

Language: Английский

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Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 21, 2025

Respiratory diseases are a leading cause of morbidity in children globally, with significant healthcare costs. The overuse conventional treatments like antibiotics has raised concerns about antibiotic resistance and side effects. Lacticaseibacillus rhamnosus GG (LGG), one the most extensively studied probiotics, gained attention as potential adjunct therapies due to their ability modulate gut microbiota immune responses. This review aims assess effectiveness LGG managing pediatric respiratory diseases, including tract infections (RTI), cystic fibrosis (CF), asthma. Clinical trials suggest can reduce incidence severity RTI, improving CF symptoms, enhancing quality life children. However, evidence for its benefits asthma remains inconclusive. Its mechanisms include modulating responses, barrier function, maintaining microbial homeostasis via gut-lung axis. Existing studies often limited by small sample sizes, heterogeneity intervention protocols, short follow-up periods. Emerging technologies novel formulations, hold promise unraveling complex interactions among LGG, axis, health. These advancements could pave way personalized probiotic therapies, highlighting cost-effective, adjunctive therapy diseases. underscores broader significance integrating into healthcare, while calling future research overcome current limitations, optimize clinical explore innovative therapeutic strategies.

Language: Английский

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Exploring new Bacteroidota strains: Functional Diversity and Probiotic Characteristics

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Abstract Bacteroidota, a diverse phylum of bacteria, are increasingly recognized for their significant contributions to host health, particularly through antimicrobial and probiotic properties. This study investigates the functional diversity potential 42 new Bacteroidota strains enriched identified from hosts, including mouse ceca human stool samples. Using 16S rRNA gene sequencing, we phylogenetically characterized genera Bacteroides, Phocaeicola Sphingobacterium assessed properties related potential. The were evaluated concerning ability inhibit biofilm formation WHO declared clinically pathogens, gram-positive Staphylococcus aureus epidermidis , gram-negative Klebsiella oxytoca Pseudomonas aeruginosa eukaryotic fungus Candida albicans. Additionally, investigated bile salt hydrolase quorum quenching activities strains, key traits associated with efficacy. Our findings demonstrate that all examined consistently exhibit capacity but different extent. Furthermore, 14 showed activity, 39 highlighting High inhibition as well activity against both autoinducers, AHL AI-2, predominantly observed in Bacteroides caecimuris muris making them attractive candidates next-generation probiotics. Overall, this advances field probiotics by identifying promising therapeutic applications potentially revolutionizing approaches microbiome-based interventions pathogen control clinical settings.

Language: Английский

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