Cardio vascular disease prediction by deep learning based on IOMT: review DOI

C Deepti,

J Nagaraja

Smart Science, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Aug. 19, 2024

The global burden of disease caused by cardiovascular diseases (CVDs) is increasing despite technical advancements in healthcare because a dramatic rise the developing nations that are experiencing rapid health transitions. World Health Organization (WHO) estimates 17.9 million deaths worldwide 2021 and connected to CVDs, or 32% all deaths. Since ancient times, people have experimented with methods extend their lives. proposed technology still long way for attaining aim lessening mortality rates. Early detection proactive management CVD risk factors crucial reducing these diseases. In recent years, researchers been exploring potential deep learning predicting depending upon data collected from IoMT devices. Deep (DL) used prediction popular this domain. Several DL techniques implemented accomplish efficient prediction-based CVD. There several steps employing model. IoT sensors process large amounts patient-related biomedical data, enabling doctors closely monitor patients make choices real-time. An outline IoT, sensors, provided after discussion cardiac its existing treatments. A complete analysis current pertinent deep-learning heart reviewed. result shows performance metrics comparison different approaches. This review undertaken pulling 44 papers published between years 2020 2023, provides thorough statistical analysis. Finally, survey will be beneficial researchers.

Language: Английский

An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement DOI Creative Commons
Chandrabhan Prajapati, Sachchida Nand, Santosh Kumar Singh

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical

Language: Английский

Citations

1
The plant endomicrobiome: Structure and strategies to produce stress resilient future crop DOI Creative Commons
Shobhit Raj Vimal, Jay Shankar Singh, Ashwani Kumar

et al.

Current Research in Microbial Sciences, Journal Year: 2024, Volume and Issue: 6, P. 100236 - 100236

Published: Jan. 1, 2024

Plants have a microbiome, diverse community of microorganisms, including bacteria, fungi, and viruses, living inside on their tissues. Versatile endophytic microorganisms inhabited in every plant part without causing disease develop microbiome or endo-microbiome. Plant endo-microbiome are drawn by the nutrient rich micro-environment, turn some microbes mutualistically endorse protect from adverse environmental stresses. interact within well-designed host equilibrium containing xylem, phloem, nutrients, phytohormones, metabolites shift according to nutritional change. regulate respond variations, pathogens, herbivores producing stress regulators, organic acids, secondary metabolites, hormones as well unknown substances signalling molecules. Endomicrobiome efficiently synthesizes multiple bioactive compounds, phytohormones with high competence. The technological innovation next generation genomics biology high-throughput multiomics techniques stepping stones illumination critical communities functional characterization that aid improving physiology, biochemistry immunity interplay for best crop productivity. This review article contains deeper insight endomicrobiome related research work last years, recruitment, niche development, dynamics, removal mechanisms, services health architecture communication, resilient future crop.

Language: Английский

Citations

5
Big data and machine learning in endophytic drug discovery: Accelerating innovations DOI
Shweta Kumari,

Ashima Jain,

Gurpreet Kaur

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 441 - 462

Published: Jan. 1, 2025

Language: Английский

Citations

0
Anti-MRSA and cytotoxic activity of a new diamide compound isolated from Aspergillus sp. H30 DOI

Long-Fen Li,

Yingying Hu, Xinzhu Wang

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: March 17, 2025

A new aromatic diamide compound, aspergillusin (1), together with three known compounds, globosterol (2), ergosterol (3), and cladosporide (4), was isolated from the crude extract of endophytic fungi Aspergillus sp. H30. The structures were elucidated using NMR MS data, finally, biosynthetic pathway compound 1 hypothesised. Compounds 1–4 tested for their antibacterial activities on six pathogenic bacteria also evaluated against human non-small cell lung cancer H1299. Among them, exhibited weak activity MRSA a strong effect bronchial epithelial line, BEAS-2B, an IC50 value 12.32 ± 0.37 μM.

Language: Английский

Citations

0
Bioprospecting of Fungi for Anticancer Compounds DOI

Aparna Ramadoss,

Venkata Giridhar Poosarla,

Shaik Sadiya

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Assessment of genome mutation analysis for tumor-informed detection of circulating tumor DNA in patients with breast cancer DOI

Mugip Rahaman Abdul Wahab,

Thirunavukkarasu Palaniyandi,

Swarnakala Thamada

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 561, P. 119818 - 119818

Published: June 14, 2024

Language: Английский

Citations

3
Multi-Label Classification of Fundus Images with Optimized Vision Transformer Based Wasserstein Deep Convolutional Generative Adversarial Network DOI

K. Sreekumar,

E. R. Vimina

SN Computer Science, Journal Year: 2024, Volume and Issue: 5(7)

Published: Aug. 29, 2024

Language: Английский

Citations

3
Regulation of bus voltage on DC microgrid using hybrid technique through charger/discharger storage DOI
Omar A. AlKawak, Hadi Saghafi, Ali A. Abdullah Albakry

et al.

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 101, P. 113620 - 113620

Published: Sept. 23, 2024

Language: Английский

Citations

3
Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy DOI Creative Commons
Nafisa Nawar Tamzi, Md. Motiur Rahman, Subhadeep Das

et al.

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 740 - 781

Published: Dec. 6, 2024

The increase in cancer incidence recent years necessitates urgent exploration of novel and alternative sources natural bioactives for targeted therapy. Approximately 75% the Earth’s surface is covered by oceans, which are thought to harbor untapped physiologically active compounds with potential efficacy against cancer. Recently, a growing focus has been on isolating investigating bioactive derived from marine sources. Bioactive metabolites diverse chemical structures, isolated various species such as algae, mollusks, actinomycetes, demonstrate wide range cancers. To our knowledge, this one articles that reviewed papers application marine-derived This study aims showcase some most current developments therapy have identified

Language: Английский

Citations

3
Small Biological Fighters Against Cancer: Viruses, Bacteria, Archaea, Fungi, Protozoa, and Microalgae DOI Creative Commons
Pathea Bruno,

Peter Biggers,

Niyogushima Nuru

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 665 - 665

Published: March 8, 2025

Despite the progress made in oncological theranostics, cancer remains a global health problem and leading cause of death worldwide. Multidrug radiation therapy resistance is an important challenge treatment. To overcome this great concern clinical practice, conventional therapies are more used combination with modern approaches to improve quality patients’ lives. In review, we emphasize how small biological entities, such as viruses, bacteria, archaea, fungi, protozoans, microalgae, well their related structural compounds toxins/metabolites/bioactive molecules, can prevent suppress or regulate malignant initiation, progression, metastasis, responses different therapies. All these fighters free-living parasitic nature and, furthermore, protozoans components human animal microbiomes. Recently, polymorphic microbiomes have been recognized new emerging hallmark cancer. Fortunately, there no limit development novel biomedicine. Thus, viral vector-based based on genetically engineered bacteriotherapy, mycotherapy anti-cancer fungal bioactive compounds, use protozoan parasite-derived proteins, nanoarchaeosomes, microalgae-based microrobots oncology, promoting biomimetic biology-inspired strategies maximize diagnostic efficiency, improved life.

Language: Английский

Citations

0