Conductive hearing loss does not affect spatial learning and memory in middle-aged guinea pigs DOI Creative Commons
Kristin M. Barry,

J. C. J. Jimena,

Hadeel Y. Tarawneh

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Hearing loss (HL) in mid-life has been suggested as a risk factor for cognitive decline. It is unclear whether this relationship due to deprivation of auditory input alone, degenerative processes, or combination. Animal models are useful investigate underlying neural mechanisms human studies can be confounded by various factors. However, most animal use young animals and often exclude females. We used middle-aged guinea pigs both sexes 8 weeks conductive HL caused spatial learning memory impairments. Forty (20 M, 20 F, ~ 12 months) were tested the Morris Water Maze (MWM) assess baseline memory. In these (10 10 F) ear canal was plugged later, again assessed MWM. No deficits observed either sex. small decline body weight suggesting some stress associated with HL, although adrenal weight, corrected did not change. Our data suggest that alone does affect cognition middle-age, line recent additional factors need present.

Language: Английский

Application of Metabolomics to Acquired Hearing Loss: Advances and Systematic Review DOI
Shuyi Wang, Mengyao Xie, Zhiyuan Wu

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109302 - 109302

Published: May 1, 2025

Language: Английский

Citations

0
Effects of Astragaloside IV on Hearing, Inflammatory Factors, and Intestinal Flora in Mice Exposed to Noise DOI Creative Commons
Junyi Li, Jian Yang,

Yun Xia

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(2), P. 122 - 122

Published: Feb. 11, 2024

Long-term exposure to noise can cause irreversible hearing loss. Considering that there is no effective drug treatment, it important seek preventive treatment for noise-induced loss (NIHL). Although astragaloside IV (AS-IV) protects against NIHL by reducing serum inflammatory factors, scarce information on the regulation of factors AS-IV prevent NIHL. We investigated thresholds and relationship between levels cytokines intestinal microbiota c57bl/6j mice exposed (103 dB SPL 4 h·d−1) 7 days, treated with or without AS-IV. Our results revealed a lower threshold TNF-α, TNF-γ, IL-6, IL-1β, IFN-γ in Additionally, increased abundance phylum Firmicutes, class Bacillus, order Lactobacillus, family Lactobacillus (p < 0.05), decreased those Bacteroidetes Bacteroidales 0.05). Bacilli negatively correlated IL-1β; Erysipelotrichaceae INF-γ; Clostridiales positively IL-1β. In conclusion, reduces elevation mice, preventing noise, under intervention AS-IV, changes correlate flora. suggest improves flora inflammation noise.

Language: Английский

Citations

1
Serum metabolome perturbation in relation to noise exposure: Exploring the potential role of serum metabolites in noise-induced arterial stiffness DOI
Zhaomin Chen,

Wenzhen Li,

Haozhe Zhang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 349, P. 123945 - 123945

Published: April 9, 2024

Language: Английский

Citations

1
Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis DOI Creative Commons

Jiang Wang,

Junhao Xiang, Peng Xiao

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Chronic tinnitus is a central nervous system disorder. Currently, the effects of gut microbiota on remain unexplored. To explore connection between and tinnitus, we conducted 16S rRNA sequencing fecal serum metabolomic analysis in cohort 70 patients with 30 healthy volunteers. We used weighted gene co-expression network method to analyze relationship metabolites. The random forest technique was utilized select metabolites taxa construct predictive models. A pronounced dysbiosis group, characterized by reduced bacterial diversity, an increased Firmicutes/Bacteroidetes ratio, some opportunistic bacteria including Aeromonas Acinetobacter were enriched. In contrast, beneficial probiotics decreased, Lactobacillales Lactobacillaceae. analysis, metabolic disturbances these differential enriched pathways neuroinflammation, neurotransmitter activity, synaptic function. models exhibited great diagnostic performance, achieving 0.94 (95% CI: 0.85–0.98) 0.96 0.86–0.99) test set. Our study suggests that changes could potentially influence occurrence chronicity exert regulatory through Overall, this research provides new perceptions into potential role metabolite pathogenesis proposes “gut-brain-ear” concept as pathomechanism underlying significant clinical implications therapeutic potential. IMPORTANCE Tinnitus affects millions people worldwide. Severe cases may lead sleep disorders, anxiety, depression, subsequently impacting patients’ lives increasing societal healthcare expenditures. However, mechanisms are poorly understood, effective interventions currently lacking. discovered metabolomics provided pathological dysregulated flora chronic tinnitus. proposed innovative “gut-brain-ear axis,” which underscores exploration impact susceptibility profile modulation. also reveal novel biomarkers associated offering conceptual framework for further investigations patients, treatment targets assessing patient prognosis. Subsequently, can be molecular markers assess prognosis tinnitus.Furthermore, transplantation treat

Language: Английский

Citations

1
The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease DOI Creative Commons

Motahare Khorrami,

Christopher J. Pastras, Paul A. Haynes

et al.

Proteomes, Journal Year: 2024, Volume and Issue: 12(2), P. 17 - 17

Published: June 4, 2024

Characterising inner ear disorders represents a significant challenge due to lack of reliable experimental procedures and identified biomarkers. It is also difficult access the complex microenvironments investigate specific pathological indicators through conventional techniques. Omics technologies have potential play vital role in revolutionising diagnosis by providing comprehensive understanding biological systems at various molecular levels. These approaches reveal valuable information about biomolecular signatures within cochlear tissue or fluids such as perilymphatic endolymphatic fluid. Proteomics identifies changes protein abundance, while metabolomics explores metabolic products pathways, aiding characterisation early diseases. Although there are different methods for identifying quantifying biomolecules, mass spectrometry, part proteomics analysis, could be utilised an effective instrument disorders. This study aims review literature on application proteomic metabolomic specifically focusing Meniere’s disease, ototoxicity, noise-induced hearing loss, vestibular schwannoma. Determining metabolite biomarkers may helpful treatment problems.

Language: Английский

Citations

0
Noise - an insidious stressor affecting xenobiotic metabolism? DOI Creative Commons
R. H. Waring, Stephen Mitchell

Xenobiotica, Journal Year: 2024, Volume and Issue: 55(1), P. 1 - 3

Published: Dec. 13, 2024

Language: Английский

Citations

0
Conductive hearing loss does not affect spatial learning and memory in middle-aged guinea pigs DOI Creative Commons
Kristin M. Barry,

J. C. J. Jimena,

Hadeel Y. Tarawneh

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Hearing loss (HL) in mid-life has been suggested as a risk factor for cognitive decline. It is unclear whether this relationship due to deprivation of auditory input alone, degenerative processes, or combination. Animal models are useful investigate underlying neural mechanisms human studies can be confounded by various factors. However, most animal use young animals and often exclude females. We used middle-aged guinea pigs both sexes 8 weeks conductive HL caused spatial learning memory impairments. Forty (20 M, 20 F, ~ 12 months) were tested the Morris Water Maze (MWM) assess baseline memory. In these (10 10 F) ear canal was plugged later, again assessed MWM. No deficits observed either sex. small decline body weight suggesting some stress associated with HL, although adrenal weight, corrected did not change. Our data suggest that alone does affect cognition middle-age, line recent additional factors need present.

Language: Английский

Citations

0