The World Journal of Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 36
Published: Dec. 23, 2024
The
relationship
between
the
gut
microbiome
and
mental
health,
particularly
depression,
has
gained
significant
attention.
This
review
explores
connection
microbial
metabolites,
dysbiosis,
depression.
microbiome,
comprising
diverse
microorganisms,
maintains
physiological
balance
influences
health
through
gut-brain
axis,
a
communication
pathway
central
nervous
system.
Journal of Fungi,
Journal Year:
2025,
Volume and Issue:
11(4), P. 279 - 279
Published: April 2, 2025
The
human
gastrointestinal
tract
harbors
a
vast
array
of
microorganisms,
which
play
essential
roles
in
maintaining
metabolic
balance
and
immune
function.
While
bacteria
dominate
the
gut
microbiome,
fungi
represent
much
smaller,
often
overlooked
fraction.
Despite
their
relatively
low
abundance,
may
significantly
influence
both
health
disease.
Advances
next-generation
sequencing,
metagenomics,
metatranscriptomics,
metaproteomics,
metabolomics,
computational
biology
have
provided
novel
opportunities
to
study
mycobiome,
shedding
light
on
its
composition,
functional
genes,
metabolite
interactions.
Emerging
evidence
links
fungal
dysbiosis
various
diseases,
including
inflammatory
bowel
disease,
colorectal
cancer,
disorders,
neurological
conditions.
mycobiome
also
presents
promising
avenue
for
precision
medicine,
particularly
biomarker
discovery,
disease
diagnostics,
targeted
therapeutics.
Nonetheless,
significant
challenges
remain
effectively
integrating
knowledge
into
clinical
practice.
This
review
examines
microbiota,
highlighting
analytical
methods,
associations
with
potential
role
medicine.
It
discusses
pathways
translation,
diagnosis
treatment,
while
addressing
key
barriers
implementation.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10255 - 10255
Published: Sept. 24, 2024
Hematologic
malignancies
(HMs),
including
leukemia,
lymphoma,
and
multiple
myeloma,
involve
the
uncontrolled
proliferation
of
abnormal
blood
cells,
posing
significant
clinical
challenges
due
to
their
heterogeneity
varied
treatment
responses.
Despite
recent
advancements
in
therapies
that
have
improved
survival
rates,
particularly
chronic
lymphocytic
leukemia
acute
lymphoblastic
treatments
like
chemotherapy
stem
cell
transplantation
often
disrupt
gut
microbiota,
which
can
negatively
impact
outcomes
increase
infection
risks.
This
review
explores
complex,
bidirectional
interactions
between
microbiota
cancer
patients
with
HMs.
Gut
influence
drug
metabolism
through
mechanisms
such
as
production
enzymes
bacterial
β-glucuronidases,
alter
efficacy
toxicity.
Moreover,
microbial
metabolites
short-chain
fatty
acids
modulate
host
immune
response,
enhancing
effectiveness.
However,
therapy
reduces
diversity
beneficial
bacteria,
Bifidobacterium
Faecalibacterium,
while
increasing
pathogenic
bacteria
Enterococcus
Escherichia
coli.
These
findings
highlight
critical
need
preserve
during
treatment.
Future
research
should
focus
on
personalized
microbiome-based
therapies,
probiotics,
prebiotics,
fecal
transplantation,
improve
quality
life
for
hematologic
malignancies.
