Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 16, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is the most common disorder worldwide, with an estimated global prevalence of more than 31%. steatohepatitis (MASH), formerly (NASH), a progressive form MASLD characterized by hepatic steatosis, inflammation, and fibrosis. This review aims to provide comprehensive analysis extrahepatic manifestations MASH, focusing on chronic diseases related cardiovascular, muscular, renal systems. A systematic published studies literature was conducted summarize findings systemic impacts MASH. The focused association MASH metabolic comorbidities, cardiovascular mortality, sarcopenia, kidney disease. Mechanistic insights into concept lipotoxic inflammatory "spill over" from MASH-affected were also explored. are highly associated (50%-80%) other comorbidities such impaired insulin response, type 2 diabetes, dyslipidemia, hypertriglyceridemia, hypertension. Furthermore, 90% obese patients diabetes have Data suggest that in middle-aged individuals (especially those aged 45-54), independent risk factor for plays crucial role mediating pathological effects observed. Understanding multifaceted impact heart, muscle, early detection stratification. knowledge timely implementing management strategies addressing multi-organ involvement pathogenesis.

Language: Английский

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Bacteroides ovatus alleviates high-fat and high-cholesterol -induced nonalcoholic fatty liver disease via gut-liver axis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117156 - 117156

Published: July 19, 2024

Gut microbiota acts as a critical regulator in the development of nonalcoholic fatty liver disease (NAFLD), making probiotics promise therapeutic strategy. Studies are needed to identify beneficial Bacteroides strains against NAFLD. ovatus (B. ovatus) may also exhibit therapy effect on The aim this work was evaluate B. NAFLD and examine mechanism. C57BL/6 J male mice were randomly divided into three groups: control group (NCD) that received standard diet, model (M) with high-fat high-cholesterol (HFHC) M_Bo fed HFFC supplemented ovatus. Treatment could reduce body weight, prevent hepatic steatohepatitis injury. Mechanistically, induced changes gut microbial diversity composition, characterized by decreased Firmicutes/Bacteroidetes (F/B) ratio mice, lower abundance Proteobacteria, Verrucomicrobiota at phylum level Ruminococcus_torques_group, Ruminococcus_gauvreauii_group, Erysipelatoclostridium genus level, simultaneously remarkablely higher fecal Lachnospiraceae_NK4A136_group, norank_f__Oscillospiraceae, Colidextribacter. Compared M group, treated showed an markedly altered short chain acids (SCFAs), decline serum levels lipopolysaccharide (LPS), CD163, IL-1β, TNF-α, reduced macrophages livers. Additionally, treatment caused downregulation genes involved denovo lipogenesis (such Srebfl, Acaca, Scd1, Fasn), which accompanied upregulation related acid oxidation Ppara). In conclusion, study provides evidence ameliorate modulating gut-liver axis.

Language: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 241 - 241

Published: Jan. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Language: Английский

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Next-Generation Probiotics and Chronic Diseases: A Review of Current Research and Future Directions

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(50), P. 27679 - 27700

Published: Nov. 26, 2024

The burgeoning field of microbiome research has profoundly reshaped our comprehension human health, particularly highlighting the potential probiotics and fecal microbiota transplantation (FMT) as therapeutic interventions. While benefits traditional are well-recognized, efficacy mechanisms remain ambiguous, FMT's long-term effects still being investigated. Recent advancements in high-throughput sequencing have identified gut microbes with significant health benefits, paving way for next-generation (NGPs). These NGPs, engineered through synthetic biology bioinformatics, designed to address specific disease states enhanced stability viability. This review synthesizes current on NGP stability, challenges delivery, their applications preventing treating chronic diseases such diabetes, obesity, cardiovascular diseases. We explore physiological characteristics, safety profiles, action various strains while also addressing opportunities presented by integration into clinical practice. NGPs revolutionize microbiome-based therapies improve outcomes is immense, underscoring need further optimize ensure safety.

Language: Английский

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Fucoidan ameliorates alcohol-induced liver injury in mice through Parabacteroides distasonis-mediated regulation of the gut-liver axis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135309 - 135309

Published: Sept. 3, 2024

Language: Английский

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Microbial signatures in head and neck squamous cell carcinoma: an in silico study

Journal of Applied Oral Science, Journal Year: 2025, Volume and Issue: 33

Published: Jan. 1, 2025

Abstract Objectives The oral cavity harbors a plethora of bacterial species. Dysbiosis and gut microbiota is associated with several systemic pathologies, such as cancer, obesity, diabetes, atherosclerosis gastrointestinal diseases. Imbalance in the oral-gut microbial axis has been head neck squamous cell carcinoma (HNSCC). This study aims to analyze profile HNSCC across various taxonomic units, investigate molecular patterns prevalent phylum HNSCC, compare (GI) using computational analysis. Methodology microbe-host transcriptomic, proteomic, epigenetic analyses GI carcinomas were performed Cancer Microbiome Atlas (TCMA) database. differential expression host’s mRNA transcripts proteins tumor microbiome analyzed University Alabama at Birmingham data analysis (UALCAN) Clinical Proteomic Tumor Analysis Consortium (CPTAC) websites. Results A decrease Actinobacteria an enrichment Flavobacteria class level, Neisseriales, Pasteurellales, Campylobacterales order Pasteurellaceae, Flavobacteriaceae, Campylobacteraceae, Peptoniphilaceae family Hemophilus, Porphyromonas, Leptotrichia genus level observed compared normal mucosa. RICTOR protein, (HIST1H2BB, SCARNA11, TBC1D21 gene), hsa-miR-200a-5p miRNA significantly correlated species HNSCC. major increase Actinobacteria, Fusobacteria, Spirochaetes was carcinoma. Conclusion dysbiosis, reflected by abundance carcinomas, suggests implication their genomic interactions host carcinogenesis.

Language: Английский

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Culturable Human Microorganisms and the Impact of Transportation Conditions on Cultivability

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 549 - 549

Published: Feb. 28, 2025

The composition of the human microbiome is a critical health indicator, and culture-independent methodologies have substantially advanced our understanding human-associated microorganisms. However, precise identification characterization microbial strains require culture-based techniques. Recently, resurgence culturomics, combined with high-throughput sequencing technology, has reduced high labor demand pure culture methods, facilitating more efficient comprehensive acquisition culturable strains. This study employed an integrated approach combining culturomic to identify microorganisms on scalp in saliva feces. Several Staphylococcus were identified from scalp, whereas anaerobic dominant fecal samples. Additionally, highlighted beneficial effects transportation conditions (liquid nitrogen treatment, dry ice transport, dimethyl sulfoxide [DMSO] buffer) preserving A robust methodology was developed for large-scale optimized transport that enhance potential isolating greater diversity

Language: Английский

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Naringenin cationic lipid-modified nanoparticles mitigate MASLD progression by modulating lipid homeostasis and gut microbiota

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Naringenin (NAR) possesses various pharmacological activities including antioxidant, anti-inflammatory, and hepatoprotective effects. However, its therapeutic efficacy is limited by hydrophobic crystalline nature. This study aimed to investigate the potential molecular mechanisms of NAR efficiently loaded into cationic nanoparticles (NP-NAR) for treating metabolic dysfunction-associated steatotic liver disease (MASLD) in a mouse model. The results demonstrated that NP-NAR effectively ameliorated lipid metabolism dysbiosis, oxidative stress, insulin resistance, inflammation MASLD mice. Transcriptomic analysis data revealed promoted fatty acid oxidation via activation PPAR signaling pathway, reduced hepatic uptake lipogenesis inhibiting expressions key genes CD36, ACC, FASN. Moreover, modulated cholesterol classical bile synthesis pathway. 16 S rDNA gene sequencing disbalanced gut microbiota mice, whereas treatment statistically reversed abundance changes several intestinal bacteria at phylum genus levels, which partly contributed balance metabolite production, short-chain acids. In conclusion, these findings suggest may be promising candidate obesity-associated MASLD, offering new insight underlying NAR's against MASLD.

Language: Английский

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The hepatocellular model of fatty liver disease: from current imaging diagnostics to innovative proteomics technologies

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 5, 2025

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a prevalent chronic liver condition characterized by lipid accumulation and inflammation, often progressing to severe damage. We aim review the pathophysiology, diagnostics, clinical care of MASLD, highlights advances in proteomic technologies. Recent proteomics technologies have improved identification novel biomarkers therapeutic targets, offering insight into molecular mechanisms underlying MASLD progression. focus on application mass spectrometry-based including single cell proteomics, proteogenomics, extracellular vesicle (EV-omics), exposomics for biomarker discovery, emphasizing potential blood-based panels noninvasive diagnosis personalized medicine. Future research directions are presented develop targeted therapies improve outcomes patients.

Language: Английский

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The current findings on the gut-liver axis and the molecular basis of NAFLD/NASH associated with gut microbiome dysbiosis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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