Nonphytotoxic and pH-responsive ZnO-ZIF‑8 loaded with honokiol as a “nanoweapon” effectively controls the soil-borne bacterial pathogen Ralstonia solanacearum

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134502 - 134502

Published: May 3, 2024

Language: Английский

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Breakthrough Advances in Beta-Lactamase Inhibitors: New Synthesized Compounds and Mechanisms of Action Against Drug-Resistant Bacteria

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 206 - 206

Published: Feb. 3, 2025

Beta-lactam drugs hold a central place in the antibacterial arsenal, and production of beta-lactamases by drug-resistant bacteria has severely compromised effectiveness nearly all available beta-lactams. Therefore, face increasing threat drug resistance, combined use beta-lactamase inhibitors (BLIs) with beta-lactam antibiotics is crucial for treating infections caused bacteria. Hence, development BLIs always been hot topic field medicinal chemistry. In recent years, significant progress made screening active enhancing affinity enzymes stability their complexes, based on design concept competitive inhibitors. Here, we review effects mechanisms newly synthesized various to provide ideas subsequent

Language: Английский

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Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: May 7, 2025

A total of 366 tonsillar tissue samples were collected from healthy free-range pigs owned by farmers across 12 districts in Baise City, Guangxi, China. This initiative successfully isolated six strains Carbapenem-Resistant Enterobacteriaceae (CRE), including four Escherichia coli , and one Klebsiella aerogenes Morganella morganii . Assessments utilizing Carbapenemase inhibitor enhancement test, conjunction with the ResFinder resistance gene database, revealed that five carried bla NDM-5 gene, while strain possessed NDM-1 gene. The overall positivity rate for CRE was determined to be 1.64%. Conjugation tests further demonstrated ability NDM genes transfer recipient strains. Additionally, an analysis genetic environment surrounding showed similarities among within same geographic region, suggesting these may have originated a common ancestor spread horizontally different clones. study provides valuable insights into transmission

Language: Английский

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Decoding the enigma: unveiling the transmission characteristics of waterfowl-associated blaNDM-5-positive Escherichia coli in select regions of China

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

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Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing outer membrane destabilization

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

New Delhi metallo-β-lactamase-1 (NDM-1)-producing bacteria are resistant to nearly all available β-lactam antibiotics and have become a public health threat. Antibiotic resistance often carries fitness costs, which typically manifest as reduced bacterial growth rate. Here, we investigated the mechanism of cost in NDM-1-producing bacteria. Our findings revealed that strains expressing bla

Language: Английский

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Revealing sRNA expression profiles of NDM-5-producing CRKP and explore the role of sRNA207 in NDM-5-producing CRKP resistance

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

New Delhi metallo-beta-lactamase-5 (NDM-5)-producing carbapenem-resistant

Language: Английский

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