Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This
review
explores
the
synergistic
potential
of
natural
products
and
nanotechnology
for
viral
infections,
highlighting
key
antiviral,
immunomodulatory,
antioxidant
properties
to
combat
pandemics
caused
by
highly
infectious
viruses.
These
often
result
in
severe
public
health
crises,
particularly
affecting
vulnerable
populations
due
respiratory
complications
increased
mortality
rates.
A
cytokine
storm
is
initiated
when
an
overload
pro-inflammatory
cytokines
chemokines
released,
leading
a
systemic
inflammatory
response.
Viral
mutations
limited
availability
effective
drugs,
vaccines,
therapies
contribute
continuous
transmission
virus.
The
coronavirus
disease-19
(COVID-19)
pandemic
has
sparked
renewed
interest
product-derived
antivirals.
efficacy
traditional
medicines
against
infections
examined.
Their
anti-inflammatory,
are
highlighted.
discusses
how
enhances
herbal
combating
infections.
Language: Английский
Post COVID-19 vaccination binding and neutralizing antibody with or without previous infection: An 18-month longitudinal study in Indonesia
Tonang Dwi Ardyanto,
No information about this author
Khariri Khariri,
No information about this author
Telly Purnamasari Agus
No information about this author
et al.
Narra J,
Journal Year:
2024,
Volume and Issue:
4(2), P. e1071 - e1071
Published: Aug. 31, 2024
Due
to
the
persisting
development
of
SARS-CoV-2
variants,
studies
on
kinetics,
duration,
and
function
antibodies
are
essential
for
vaccine
long-term
immunity
prediction.
This
longitudinal
study
examined
post-vaccination
antibody
responses
in
people
after
receiving
CoronaVac
or
ChAdOx1
vaccines
with
without
a
history
infection.
Conducted
Indonesia
between
August
2021
May
2023,
this
involved
121
participants
divided
into
two
groups
based
received
types
monitored
18
months
post-second
dose
vaccination
by
assessing
binding
(BAb)
level
neutralizing
(NAb)
inhibition
rate
at
six
time
points.
The
also
documented
participants’
age,
gender,
body
mass
index
(BMI).
Before
first
vaccination,
85
(70.25%)
were
reactive
BAb
(defined
≥50
AU/mL)
indicating
In
group,
only
53.1%
BAb.
However,
100%
positive
NAb
≥30%),
which
indicates
past
infection
low
initial
rapidly
decreasing
levels.
81,9%
reactive,
while
54.2%
NAb,
suggesting
recent
high
but
relatively
rate.
During
levels
fluctuated.
NAb.
No
significant
difference
response
was
among
history.
Also,
no
impact
presented
factors
sex,
BMI.
findings
highlight
crucial
public
health
how
strategies
could
be
optimized
effectively
during
post-pandemic.
Language: Английский
The Ambivalence of Post COVID-19 Vaccination Responses in Humans
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1320 - 1320
Published: Oct. 17, 2024
The
Coronavirus
disease
2019
(COVID-19)
pandemic,
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
has
prompted
a
massive
global
vaccination
campaign,
leading
to
the
rapid
development
and
deployment
of
several
vaccines.
Various
COVID-19
vaccines
are
under
different
phases
clinical
trials
include
whole
virus
or
its
parts
like
DNA,
mRNA,
protein
subunits
administered
directly
through
vectors.
Beginning
in
2020,
few
mRNA
(Pfizer-BioNTech
BNT162b2
Moderna
mRNA-1273)
adenovirus-based
(AstraZeneca
ChAdOx1-S
Janssen
Ad26.COV2.S)
were
recommended
WHO
for
emergency
use
before
completion
phase
3
4
trials.
These
mostly
two
three
doses
at
defined
frequency
between
doses.
While
these
vaccines,
mainly
based
on
viral
nucleic
acids
conferred
protection
against
progression
SARS-CoV-2
infection
into
COVID-19,
prevented
death
due
disease,
their
also
been
accompanied
plethora
side
effects.
Common
effects
localized
reactions
such
as
pain
injection
site,
well
systemic
fever,
fatigue,
headache.
symptoms
generally
mild
moderate
resolve
within
days.
However,
rare
but
more
serious
have
reported,
including
allergic
anaphylaxis
and,
some
cases,
myocarditis
pericarditis,
particularly
younger
males.
Ongoing
surveillance
research
efforts
continue
refine
understanding
adverse
effects,
providing
critical
insights
risk-benefit
profile
Nonetheless,
overall
safety
supports
continued
combating
with
regulatory
agencies
health
organizations
emphasizing
importance
preventing
COVID-19's
outcomes.
In
this
review,
we
describe
types
summarize
various
autoimmune
inflammatory
response(s)
manifesting
predominantly
cardiac,
hematological,
neurological,
psychological
dysfunctions.
incidence,
presentation,
risk
factors,
diagnosis,
management
possible
mechanisms
contributing
discussed.
review
highlights
potential
ambivalence
human
response
post-COVID-19
necessitates
need
mitigate
Language: Английский
Bid Protein: A Participant in the Apoptotic Network with Roles in Viral Infections
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2385 - 2385
Published: March 7, 2025
The
BH3-interacting
domain
death
agonist
(Bid),
a
proapoptotic
signaling
molecule
of
the
B-cell
lymphoma
2
(Bcl-2)
family,
is
key
regulator
mitochondrial
outer
membrane
(MOM)
permeability.
Uniquely
positioned
at
intersection
extrinsic
and
intrinsic
apoptosis
pathways,
Bid
links
receptor
to
mitochondria-dependent
cascade
can
also
be
activated
by
endoplasmic
reticulum
(ER)
stress.
In
its
active
forms,
cleaved
(cBid)
truncated
(tBid),
it
disrupts
MOM
integrity
via
Bax/Bak-dependent
independent
mechanisms.
Apoptosis
plays
dual
role
in
viral
infections,
either
promoting
or
counteracting
propagation.
Consequently,
viruses
modulate
favor
their
replication.
deregulation
activity
contributes
oncogenic
transformation,
inflammation,
immunosuppression,
neurotoxicity,
pathogen
propagation
during
various
infections.
this
work,
we
explore
Bid’s
structure,
function,
activation
processes,
targeting.
We
describe
induction
involvement
infections
with
multiple
viruses.
Additionally,
discuss
therapeutic
potential
antiviral
strategies.
Understanding
pathways
offers
valuable
insights
into
host–virus
interactions
pathogenesis
This
knowledge
may
facilitate
development
novel
approaches
combat
virus-associated
diseases
effectively.
Language: Английский
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS‐CoV‐2‐Induced Immune Responses
Immunology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
ABSTRACT
The
association
between
COVID‐19
and
autoimmune
diseases
has
gained
increasing
recognition,
yet
the
specific
targets
of
SARS‐CoV‐2‐induced
IgG
are
currently
in
focus
for
several
studies.
This
study
aims
to
explore
proteomic
these
antibodies
their
potential
role
autoimmunity.
We
utilised
a
human
proteome
microarray
encompassing
23
736
unique
proteins,
including
isoform
variants
fragments,
as
catalogued
by
Human
Protein
Atlas.
Serum
samples
were
analysed
from
four
groups:
healthy
controls
(N‐exp
HC),
individuals
vaccinated
with
protein‐based
vaccines
(N‐Cov
Vac)
patients
moderate
or
severe
(COVID‐Mod
COVID‐Sev).
evaluation
revealed
recognise
multiple
proteins.
Key
included
interferon
alpha
(IFN‐α),
tumour
growth
factor
beta
(TGF‐β),
interleukin
1
(IL‐1),
CXCL16,
TGF‐β
receptors,
CD34,
CD47
BCL2.
also
targeted
proteins
genes
overexpressed
various
immune
cells,
such
CD4+
CD8+
T
γδ
B
dendritic
cells
NK
cells.
Reactivity
was
observed
specifically
expressed
organs,
brain,
liver,
lungs
heart.
Targeting
patterns
differed
controls,
some
showing
differential
recognition
versus
cases.
Furthermore,
we
evaluated
protein–protein
interaction
network
(PPIN)
all
minimal
structural
homology
co‐expression
among
almost
no
relation
SARS‐CoV‐2
system
reactome.
results
suggest
that
profile
autoantibodies
is
associated
disease
severity.
In
contrast,
protein‐vaccinated
exhibited
similar
non‐exposed
suggesting
autoreactive
linked
active
infection.
These
findings
reveal
complex
idiotypes
capable
targeting
not
merely
through
simple
cross‐recognition
homologous
highlights
need
further
investigations
determine
whether
they
may
influence
pathophysiology
its
clinical
outcomes.
Language: Английский
Electron Tomography as a Tool to Study SARS-CoV-2 Morphology
Hong Wu,
No information about this author
Yoshihiko Fujioka,
No information about this author
Shoichi Sakaguchi
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11762 - 11762
Published: Nov. 1, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
a
novel
betacoronavirus,
is
the
causative
agent
of
COVID-19,
which
has
caused
economic
and
social
disruption
worldwide.
To
date,
many
drugs
vaccines
have
been
developed
for
treatment
prevention
COVID-19
effectively
controlled
global
epidemic
SARS-CoV-2.
However,
SARS-CoV-2
highly
mutable,
leading
to
emergence
new
variants
that
may
counteract
current
therapeutic
measures.
Electron
microscopy
(EM)
valuable
technique
obtaining
ultrastructural
information
about
intracellular
process
virus
replication.
In
particular,
EM
allows
us
visualize
morphological
subcellular
changes
during
virion
formation,
would
provide
promising
avenue
development
antiviral
agents
effective
against
variants.
this
review,
we
present
our
recent
findings
using
transmission
electron
(TEM)
combined
with
tomography
(ET)
reveal
morphologically
distinct
types
particles,
demonstrating
TEM
ET
are
tools
visually
understanding
maturation
status
in
infected
cells.
This
review
also
discusses
application
analysis
evaluation
genetically
engineered
RNA
viruses.
Language: Английский