Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 18, 2024
Language: Английский
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: April 18, 2024
Glioma, the most prevalent primary tumor of central nervous system, is characterized by a poor prognosis and high recurrence rate. The interplay between microbes, such as gut microbiota, host has underscored significant impact microorganisms on disease progression. Bifidobacterium, beneficial bacterial strain found in human animal intestines, exhibits inhibitory effects against various diseases. However, existing body evidence pertaining to influence Bifidobacterium glioma remains insufficient. Here, we that reduces volume prolongs survival time an orthotopic mouse model glioma. Experiments elucidated suppresses MEK/ERK cascade. Additionally, noted increase α-diversity along with augmented relative abundance microbiota. This rise levels within intestine may be attributed concurrent induced alterations serum metabolites, particularly those comprised organonitrogen compounds. Thus, our findings showed can suppress growth inhibiting cascade regulating tumor, metabolites mice, indicating promising therapeutic prospects
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 17, 2024
The intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis prognosis, crucial improving patient outcomes. This comprehensive review synthesizes current findings on microbiome's contribution to CRC pathogenesis, highlighting its potential as a biomarker non-invasive screening strategies. We explore mechanisms through which influences CRC, including roles in inflammation, metabolism, immune response modulation. Furthermore, we assess viability of microbial signatures predictive tools offering insights into personalized treatment approaches. Our analysis underscores necessity advanced metagenomic studies elucidate complex microbiome-CRC nexus, aiming refine diagnostic accuracy prognostic assessment clinical settings. propels forward understanding capabilities, paving way microbiome-based interventions management.
Language: Английский
Citations
6
Process Biochemistry, Journal Year: 2024, Volume and Issue: 144, P. 6 - 19
Published: May 14, 2024
Language: Английский
Citations
5
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125416 - 125416
Published: Feb. 28, 2025
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 251 - 251
Published: Feb. 28, 2025
CRC remains a significant public health challenge due to its high prevalence and mortality rates. Emerging evidence highlights the critical role of gut microbiota in both pathogenesis efficacy treatment strategies, including chemotherapy immunotherapy. Dysbiosis, characterized by imbalances microbial communities, has been implicated progression therapeutic outcomes. This review examines intricate relationship between composition CRC, emphasizing potential for profiles serve as biomarkers early detection prognosis. Various interventions, such prebiotics, probiotics, postbiotics, fecal transplantation, dietary modifications, aim restore balance shift dysbiosis toward eubiosis, thereby improving Additionally, integration profiling into clinical practice could enhance diagnostic capabilities personalize advancing field oncology. The study intratumoral offers new prognostic tools that, combined with artificial intelligence algorithms, predict responses assess risk adverse effects. Given growing understanding microbiome–cancer axis, developing microbiota-oriented strategies prevention holds promise patient care
Language: Английский
Citations
0
Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(4), P. e011155 - e011155
Published: April 1, 2025
Background Gut microbiota can significantly alter the risk or progression of cancer by maintaining gut immune system homeostasis. However, exact mechanism which and its metabolites influence colorectal tumorigenesis is unclear. Methods The roles tryptophan metabolite indole-3-acetic acid (IAA) in inflammation tumor development were investigated dextran sodium sulfate (DSS) azoxymethane (AOM)-DSS mouse models with without IAA supplementation Lactobacillus reuteri -produced IAA. Pregnane X receptor (PXR) knockout (KO) mice aryl hydrocarbon KO used to explore regulates interleukin (IL)-35 expression. IL-35 + cells stimulated vitro analyzed flow cytometry. Additionally, liquid chromatography-mass spectrometry. Results We found that IAA, a produced L. , inhibit colitis inducing expression immunosuppressant cells. HuREG3α IECtg had high levels intestinal microbiota-derived these resistant AOM-DSS-induced cancer. Patients also low peripheral blood Further studies revealed IAA-producing alleviated symptoms inhibited colon tumors macrophages, T cells, B produce IL-35. Finally, PXR completely abolished effects on Conclusion demonstrate improve precancerous inflammatory environment through IL-35, thereby inhibiting tumorigenesis, suggesting may be preventive factor for colitis-related cancers.
Language: Английский
Citations
0
Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2236 - 2236
Published: June 15, 2024
In 2022, colorectal cancer (CRC) was the third most prevalent malignancy worldwide. The therapeutic approach for CRC typically involves a multimodal regimen. human gut microbiota comprises over 35,000 bacterial species. composition of is influenced by dietary intake, which plays crucial role in food absorption, nutrient extraction, and development low-grade inflammation. Dysbiosis key driver inflammation strongly associated with development. While microbiome influences initiation progression, emerging evidence suggests modulating efficacy toxicity treatments. Therapeutic strategies targeting microbiome, such as probiotics, hold promise effective interventions modern therapeutical to CRC. For example, Microbiota Implementation Reduce Anastomotic Colorectal Leaks (MIRACLe) implementation has resulted improvements clinical outcomes, including reduced incidence anastomotic leakage (AL), surgical site infections (SSIs), reoperation, well shorter recovery times hospital stays compared control group. Therefore, this review aims describe current state knowledge regarding involvement pathogenesis its potential implications treat
Language: Английский
Citations
3
Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2400 - 2400
Published: July 24, 2024
Postbiotics are defined as a preparation of inanimate microorganisms and/or their components that confers health benefit to the host. They range from cell wall fragments metabolites, bacterial lysates, extracellular vesicles, and short-chain fatty acids (SCFAs). may influence carcinogenesis via variety mechanisms. can promote homeostatic immune responses, reduce inflammation, induce selective cytotoxicity against tumor cells, well enabling control proliferation enhancing intestinal epithelial barrier function. Therefore, probiotics serve an adjunct strategy in anticancer treatment together with chemotherapy immunotherapy. Up now, only relevant postbiotics used interventions oncological patients remain vitamin K molecules, few phase-II III trials available. In fact, postbiotics’ levels strictly dependent on gut microbiota’s composition, which vary between individuals be altered under different physiological pathological conditions. lack consistent clinical evidence supporting efficacy is due poor bioavailability, short half-life, fluctuating levels. Synbiotics, mixture prebiotics probiotics, expected have more homogeneous bioavailability respect greater potential for future development. this review, we focus role adjuvant therapy cancer treatment.
Language: Английский
Citations
3
Food & Function, Journal Year: 2024, Volume and Issue: 15(18), P. 9053 - 9069
Published: Jan. 1, 2024
Postbiotics derived from different sourdough confer protective effects against high-fat diet-induced intestinal damage in zebrafish, with variation observed across species.
Language: Английский
Citations
1
Journal of Nutrition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1