Soil Microorganisms: Their Role in Enhancing Crop Nutrition and Health

Diversity, Journal Year: 2024, Volume and Issue: 16(12), P. 734 - 734

Published: Nov. 29, 2024

Maintaining soil health is fundamental to sustaining agricultural productivity, however, the intricate role of microbial diversity in this process not fully understood. Current research acknowledges that microorganisms including bacteria, fungi, and archaea are pivotal driving essential functions such as nutrient cycling, organic matter decomposition, disease suppression. However, impacts global environmental changes intensive practices on these remain a critical gap literature. This significant because decline could severely compromise health, consequently crop productivity. Here, we provide comprehensive review factors influencing examine their implications for performance. We assess both natural pH, moisture, temperature, vegetation type well human-induced tillage systems fertilizer application. The synthesizes recent findings how shape communities functional roles structure formation, Our analysis highlights mechanisms by which enhances plant growth yield, addressing understanding direct links between outcomes. underscore urgent need sustainable protect enhance safeguard long-term fertility By challenges manipulating integrating ecology with management practices, advances our ability sustain face changes.

Language: Английский

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Streptomyces sp. VITGV156 secondary metabolite binds pathogenic protein PBP2a and Beta-lactamase

Frontiers in Bioinformatics, Journal Year: 2025, Volume and Issue: 5

Published: March 26, 2025

Introduction The genus Streptomyces is renowned for its prolific production of bioactive compounds, including antibiotics and secondary metabolites with pharmaceutical applications. This study focuses on sp. VITGV156, an isolate promising antimicrobial properties, aiming to characterize genomic potential compounds through computational experimental analyses. Methods Genomic sequencing VITGV156 was performed identify biosynthetic gene clusters (BGCs) associated metabolite production. Antimicrobial assays were conducted using crude extracts against Gram-positive Gram-negative pathogens. Gas Chromatography-Mass Spectrometry (GC-MS) employed metabolites. Additionally, ADME (Absorption, Distribution, Metabolism, Excretion) analysis molecular docking studies assess drug-like properties binding affinities selected bacterial target proteins (PDB IDs: 5M18 6NVU). Results genome determined be 8.18 Mb a G+C content 72.61%, containing 29 BGCs responsible the biosynthesis agents such as nystatin fluostatins. In vitro confirmed strong efficacy various pathogens, Escherichia coli exhibiting highest susceptibility. Molecular 45 identified revealed ranging from -4.0 -7.5 kcal/mol (5M18) -3.9 -7.2 (6NVU). Among squalene (ligand 43) displayed potent antibacterial antifungal activity, whereas 2,5-piperazinedione, 3-(hydroxymethyl)-6-(phenylmethyl)- 40) exhibited potential. Conversely, fumaric acid, monoamide, N-benzyl-N-phenylethyl-, ethyl ester 38) demonstrated weak activity. Discussion highlights valuable source novel agents. identification unique genes suggests possible application in combating multidrug-resistant Further studies, purification vivo testing, are necessary validate these findings explore their therapeutic

Language: Английский

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Biosynthetic Pathway of psi, psi-Carotene from Streptomyces sp. VITGV38 (MCC 4869)

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Endophytic Streptomyces play a crucial role in plant-microbe interactions, often exhibiting beneficial biological activities, including the production of bioactive secondary metabolites. This study aimed to characterize carotene biosynthetic pathway newly discovered sp. VITGV38, isolated from tomato (Lycopersicon esculentum). The strain (Streptomyces MCC4869) was cultured starch casein broth, and its metabolite profile analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). Whole-genome sequencing performed Illumina platform, gene clusters (BGCs) were identified antiSMASH. Metabolite analysis revealed presence pigmented compounds, psi, psi-carotene, detected at retention time 25.094, constituting 1.26% crude extract. uncovered an 8.27 Mb genome encoding 26 distinct clusters. Notably, scaffold 26.3 as terpene cluster, accounting for 62% total content associated with carotenoid β-carotene production. These findings highlight biotechnological potential VITGV38 sustainable microbial carotenoids, offering eco-friendly alternative synthetic pigments. provides valuable insights into biosynthesis industrial applications.

Language: Английский

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Antibacterial, Antifungal, and Cytotoxic Effects of Endophytic Streptomyces Species Isolated from the Himalayan Regions of Nepal and Their Metabolite Study

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2192 - 2192

Published: Sept. 26, 2024

Recently, antimicrobial-resistant pathogens and cancers have emerged as serious global health problems, highlighting the immediate need for novel therapeutics. Consequently, we aimed to isolate characterize endophytic

Language: Английский

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Enhancing Solanine Production and Antifungal Activity by Streptomyces abikoensis XH-17 through Combined Ribosome Engineering and Post-Translational Modification

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105618 - 105618

Published: Dec. 1, 2024

Language: Английский

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