Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation DOI

Maryam Kananivand,

Fatemeh Nouri,

Mohammad Hasan Yousefi

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: April 1, 2025

Language: Английский

Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective DOI

Zahra Sadat Razavi,

Shahrzad Aliniay Sharafshadehi,

Mohammad Hasan Yousefi

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 31, 2025

Language: Английский

Citations

5
Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges DOI Creative Commons

Kamran Sheikhi,

Sara Ghaderi,

Hassan Firouzi

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 3, 2025

Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.

Language: Английский

Citations

1
Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond DOI Creative Commons
Aref Yarahmadi,

Masoumeh Dorri Giv,

Reza Hosseininejad

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.

Language: Английский

Citations

1
Beyond antibiotics: mesenchymal stem cells and bacteriophages-new approaches to combat bacterial resistance in wound infections DOI
Samane Teymouri,

Mohammad Hasan Yousefi,

SeyedeMozhgan Heidari

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)

Published: Dec. 19, 2024

Language: Английский

Citations

5
Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword DOI Creative Commons

Sina Kamrani,

Reza Naseramini,

Pouria Khani

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.

Language: Английский

Citations

0
Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation DOI

Maryam Kananivand,

Fatemeh Nouri,

Mohammad Hasan Yousefi

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: April 1, 2025

Language: Английский

Citations

0