Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer

OncoTargets and Therapy, Journal Year: 2018, Volume and Issue: Volume 11, P. 3979 - 3987

Published: July 1, 2018

Circular RNA (circRNA) is a novel member of the noncoding and function as efficient microRNA sponges with gene-regulatory potential, especially circular ciRS-7 (CDR1as)/tumor suppressor miRNA-7 (miR-7) signals. However, CDR1as/miR-7 in non-small cell lung cancer (NSCLC) unknown.Normal tissues (n=20), adjacent non-tumor (n=60), NSCLC (n=60) were collected to determine expression significance CDR1as/miR-7. Lung lines A549 H460 overexpressed or knocked down CDR1as, miR-7 tumor growth etc. The CDR1as/miR-7-related pathway analyzed.CDR1as levels was robustly increased development (P<0.001) harbored highest which negatively correlated miR-7. Patients high CDR1as had TNM stage (P=0.004), more lymph nodes metastasis (LNM) (P=0.021) shorted overall survival time (OS) (P=0.0135). level an independent prognostic factor for patients NSCLC. Overexpression induced vitalities growth, could be abrogated by knockdown induce apoptosis G1/S arrest. Mechanistically, functioned up-regulate key target genes including EGFR, CCNE1 PIK3CD. results vivo further confirmed that oncogene inhibit anti-tumor effects up-regulation proliferation index Ki-67, PIK3CD levels.Overexpressed functions promotes progression via

Language: Английский

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CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p–XIAP axis

Experimental Hematology, Journal Year: 2018, Volume and Issue: 70, P. 42 - 54.e3

Published: Nov. 3, 2018

Language: Английский

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The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Jan. 22, 2018

Non-coding RNAs (ncRNAs) can be divided into circular non-coding (circRNAs) and linear RNAs. ncRNAs exist in different cell types, including normal cells, tumor cells immunocytes. Linear RNAs, such as long (lncRNAs) microRNAs (miRNAs), have been found to play important roles the regulation of immunity immunotherapy; however, functions circRNAs immunotherapy are less known. Here, we review current status emphatically discuss potential antigens immunotherapy.

Language: Английский

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Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Journal of Ovarian Research, Journal Year: 2019, Volume and Issue: 12(1)

Published: Sept. 3, 2019

Circular RNAs (circRNAs) are a class of long non-coding (lncRNAs) which have circular and closed loop structure. They ubiquitous, stable, conserved diverse RNA molecules with range activities such as translation splicing regulation, able to interacting RNA-binding proteins specially miRNA sponge. The expression patterns the circRNAs exhibited tissue specificity also, step stage specificity. Accumulating evidences approved critical role in many cancers ovarian cancer. Given that these exert their effects through multiple cellular molecular mechanisms (i.e., angiogenesis, apoptosis, growth, metastasis) involved cancer pathogenesis, RNAs, particular, act by controlling cell proliferation cancer, so that, it has been shown deregulation is associated initiation progression Therefore, they attractive introduced them biomarkers. Moreover, could be used new therapeutic candidates for developing novel treatment strategies. Here, first time, we provided comprehensive review on recent knowledge pathological roles

Language: Английский

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Hsa_circ_0001649: A circular RNA and potential novel biomarker for colorectal cancer

Biochemical and Biophysical Research Communications, Journal Year: 2018, Volume and Issue: 497(1), P. 122 - 126

Published: Feb. 1, 2018

Language: Английский

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