Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases DOI Creative Commons
Xueming Xu,

Yuanfeng Han,

Jiali Deng

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2698 - 2715

Published: March 15, 2024

Drug repurposing offers a valuable strategy for identifying new therapeutic applications existing drugs. Recently, disulfiram (DSF), drug primarily used alcohol addiction treatment, has emerged as potential treatment inflammatory diseases by inhibiting pyroptosis, form of programmed cell death. The activity DSF can be further enhanced the presence Cu

Language: Английский

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis DOI Creative Commons
Dingrui Nie, Cunte Chen, Yangqiu Li

et al.

Blood Science, Journal Year: 2022, Volume and Issue: 4(3), P. 152 - 154

Published: July 1, 2022

Regulated cell death (RCD) is essential for maintaining homeostasis and preventing diseases. Besides classical apoptosis, several novel nonapoptotic forms of RCD including NETosis, pyroptosis, ferroptosis, cuproptosis have been reported are increasingly being implicated in various cancers inflammation. Disulfiram (DSF), an aldehyde dehydrogenase inhibitor, has used clinically decades as anti-alcoholic drug. New studies shown that DSF possesses potent anti-inflammatory anti-cancer effects by regulating these new types RCD. Here, we summarize the mechanisms discuss potential application treatment inflammatory

Language: Английский

Citations

23
Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways DOI Creative Commons

Y Gan,

Ting Liu,

Weifeng Feng

et al.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2023, Volume and Issue: 31(3), P. 333 - 343

Published: Jan. 1, 2023

Various therapeutic strategies have been developed to overcome ovarian cancer. However, the prognoses resulting from these are still unclear. In present work, we screened 54 small molecule compounds approved by FDA identify novel agents that could inhibit viability of human epithelial cancer cells. Among these, identified disulfiram (DSF), an old alcohol-abuse drug, as a potential inducer cell death in Mechanistically, DSF treatment significantly reduced expression anti-apoptosis marker B-cell lymphoma/leukemia-2 (Bcl-2) and increase apoptotic molecules Bcl2 associated X (Bax) cleaved caspase-3 promote apoptosis. Furthermore, is newly effective copper ionophore, thus combination was used reduce than single treatment. Combination with also led ferredoxin 1 loss Fe-S cluster proteins (biomarkers cuproptosis). vivo, gluconate decreased tumor volume increased survival rate murine xenograft model. Thus, role revealed its for viable agent

Language: Английский

Citations

16
The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics DOI Creative Commons
Sijia Zhang, Yan Zong, Leichong Chen

et al.

Discover Oncology, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 16, 2023

Abstract More than 60 years ago, disulfiram (DSF) was employed for the management of alcohol addiction. This promising cancer therapeutic agent inhibits proliferation, migration, and invasion malignant tumor cells. Furthermore, divalent copper ions can enhance antitumor effects DSF. Molecular structure, pharmacokinetics, signaling pathways, mechanisms action current clinical results DSF are summarized here. Additionally, our attention is directed towards immunomodulatory properties we explore novel administration methods that may address limitations associated with treatments based on Despite potential these various delivery utilizing as an effective anticancer agent, further investigation essential in order to extensively evaluate safety efficacy systems.

Language: Английский

Citations

13
A cascade nanoplatform for intelligent response to tumor microenvironment and collaborative cancer therapy DOI
Tong Li,

Mingjie Rong,

Yuzhu Wang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(10), P. 2537 - 2546

Published: Jan. 1, 2024

The DCZCu nanoplatform provides a powerful multimodal synergistic anticancer strategy for tumor growth inhibition in terms of enhanced chemotherapy.

Language: Английский

Citations

5
Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases DOI Creative Commons
Xueming Xu,

Yuanfeng Han,

Jiali Deng

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2698 - 2715

Published: March 15, 2024

Drug repurposing offers a valuable strategy for identifying new therapeutic applications existing drugs. Recently, disulfiram (DSF), drug primarily used alcohol addiction treatment, has emerged as potential treatment inflammatory diseases by inhibiting pyroptosis, form of programmed cell death. The activity DSF can be further enhanced the presence Cu

Language: Английский

Citations

5