In vitro Assessment of Ulva lactuca Mediated Selenium Nanoparticles (USeNPs) through Elevating the Action of Ketoconazole Antibiotic against Pathogenic Yeast Species and Wound Healing Capacity through Inhibition of Cyclooxygenase (Cox-1) Activity DOI Open Access

Mofida E. M. Makhlof,

Mostafa M. El‐Sheekh,

Majdah M. Al-Tuwaijri

et al.

Egyptian Journal of Botany, Journal Year: 2023, Volume and Issue: 0(0), P. 0 - 0

Published: Aug. 11, 2023

U LVA selenium nanoparticles (USeNPs) were synthesized and characterized, then examined for their wound healing capacity through in vitro assay showing promising (82.27%) with USeNPs concentration (500µg/mL).We also determined the antifungal potential via agar well diffusion technique, minimum inhibitory (MIC), which was evaluated by a micro-dilution assay.The synergistic effect of individually or combination standard antibiotic (ketoconazole;100μg/mL) studied against Cryptococcus neoformans RCMB 0049001 Candida lipolytica 005007(1).Geotrichum candidum 041001 checked assay, followed transmission electron microscopy to assess different changes most sensitive fungal yeast cells.The results indicated that have C. 005007(1) achieving remarkable inhibition zones.In comparison, no detected on G. 041001.The MIC found be 78.1μg 312.5μg 005007(1), respectively.The biosynthetic strong can elevate strengthen action ketoconazole towards pathogens, this obvious In experiment synergism carried out present study based combining ketoconazole;100μg/mL USeNPs, resulted detached neoformas cells severe dramatic change.

Language: Английский

Selenium Nanoparticles: Green Synthesis and Biomedical Application DOI Creative Commons

Е. О. Михайлова

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8125 - 8125

Published: Dec. 15, 2023

Selenium nanoparticles (SeNPs) are extremely popular objects in nanotechnology. "Green" synthesis has special advantages due to the growing necessity for environmentally friendly, non-toxic, and low-cost methods. This review considers biosynthesis mechanism of bacteria, fungi, algae, plants, including role various biological substances processes reducing selenium compounds SeNPs their further packaging. Modern information approaches possible biomedical use presented: antimicrobial, antiviral, anticancer, antioxidant, anti-inflammatory, other properties, as well mechanisms these processes, that have important potential therapeutic value.

Language: Английский

Citations

47
Anti-HSV-1 agents: an update DOI Creative Commons
Wenwen Lv, Lei Zhou,

Jia Qian Wu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Herpes simplex virus type I (HSV-1) is a member of the α-herpesvirus subfamily and capable causing herpes keratitis, labialis, encephalitis. HSV-1 well known for its lytic infections at primary sites establishing latency in sensory neuronal ganglia, with occasional recurrent infections. To date, there are no approved commercially available vaccines, anti-HSV-1 drugs such as specific or non-specific nucleotide (nucleoside) analogs helicase-primase inhibitors have become main clinical agents treatment despite challenges from resistance. Therefore, development new compounds therapies key to addressing issue The present review provides an update on progress made over approximately 60 years regarding while also highlighting future perspectives controlling

Language: Английский

Citations

1
Mycosynthesis of selenium nanoparticles using Penicillium tardochrysogenum as a therapeutic agent and their combination with infrared irradiation against Ehrlich carcinoma DOI Creative Commons

Abeer I. M. EL‐Sayed,

Mostafa M. El‐Sheekh, Sahar E. Abo‐Neima

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 31, 2024

Over the past years, assessment of myco-fabricated selenium nanoparticles (SeNPs) properties, is still in its infancy. Herein, we have highly stable myco-synthesized SeNPs using molecularly identified soil-isolated fungus; Penicillium tardochrysogenum OR059437; (PeSeNPs) were clarified via TEM, EDX, UV-Vis spectrophotometer, FTIR and zeta potential. The therapeutic efficacy profile will be determined, these crystalline PeSeNPs examined for antioxidant, antimicrobial, MIC, anticancer potentials, indicating that, antioxidant activity (IC

Language: Английский

Citations

6
How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature DOI Creative Commons
Mostafa M. El‐Sheekh, Samar Sami Alkafaas, Hadeer Abdulrahman Rady

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6601 - 6638

Published: Nov. 1, 2023

The necessity to engineer sustainable nanomaterials for the environment and human health has recently increased. Due their abundance, fast growth, easy cultivation, biocompatibility richness of secondary metabolites, algae are valuable biological source green synthesis nanoparticles (NPs). aim this review is demonstrate feasibility using algal-based NPs cancer treatment. Blue-green, brown, red micro- macro-algae most commonly participating in NPs. In process, many algal bioactive compounds, such as proteins, carbohydrates, lipids, alkaloids, flavonoids phenols, can catalyze reduction metal ions addition, driving factors, including pH, temperature, duration, static conditions substrate concentration, involved facilitate Here, biosynthesis, mechanisms applications algal-synthesized therapy have been critically discussed. We also reviewed effective role synthesized anticancer treatment against breast, colon lung cancers carcinoma.

Language: Английский

Citations

12
Application of Cystoseira myrica phycosynthesized selenium nanoparticles incorporated with nano‐chitosan to control aflatoxigenic fungi in fish feed DOI
Ahmed A. Tayel,

Karima M El‐madawy,

Shaaban H. Moussa

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(12), P. 7678 - 7687

Published: May 22, 2024

The recurrent contaminations of feed materials with mycotoxigenic fungi can endanger both farmed animals and humans. Biosynthesized nanomaterials are assumingly the ideal agents to overcome fungal invasion in feed/foodstuffs, especially when utilizing sustainable sources for synthesis. Herein, phycosynthesis selenium nanoparticles (SeNPs) was targeted using Cystoseira myrica algal extract (CE), conjugation CE/SeNPs chitosan (NCt) produce potential antifungal nanocomposites controlling Aspergillus flavus isolates fish feed.

Language: Английский

Citations

4
New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway DOI Creative Commons
Badriyah S. Alotaibi,

Thanaa A. El‐Masry,

Hend Mostafa Selim

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 16, 2024

Phaeophyceae species are enticing interest among researchers working in the nanotechnology discipline, because of their diverse biological activities such as anti-inflammatory, antioxidant, anti-microbial, and anti-tumor. In present study, anti-cancer properties

Language: Английский

Citations

3
Effect of bee venom (Apis mellifera) on liver damage in mice with Ehrlich ascites carcinoma DOI Creative Commons

Shahad Falah Abass,

Mohsen Hussein,

Ahmed Hasan

et al.

Regulatory Mechanisms in Biosystems, Journal Year: 2025, Volume and Issue: 33(1), P. e25040 - e25040

Published: March 4, 2025

Cancer is a terrible illness that has enormously detrimental effects on society, the economy, health care and personal lives. In 2012, there were around 14.1 million cancer cases diagnosed worldwide, with 52.5% of those instances occurring in men 47.5% women. By 2030, number predicted to increase 21.7 million. this was responsible for 8.2 fatalities globally; by end rise 13.0 The purpose our study evaluate capability Apis mellifera venom (A.M.) reduce renal toxicity tissue damage caused Ehrlich ascites carcinoma (EAC) mice. A total forty female Swiss albino mice divided evenly among four groups (G1, control, G2, A.M., G3, EAC, G4, EAC + A.M.). findings demonstrated that, comparison group, addition co-treated resulted lower levels alpha-fetoprotein (AFP), ANA, anti-dsDNA, AST, ALT, ALP. Liver slices from showed several histological alterations, including mild fibrosis, noticeable diffuse necrosis hepatic parenchyma, inflammatory cells, clogged blood sinusoids. Conversely, liver sections EAC+Apis modest improvement hepatocytes.

Language: Английский

Citations

0
Anticancer efficacy of magnetite nanoparticles synthesized using aqueous extract of brown seaweed Rosenvingea intricata, South Andaman, India DOI Creative Commons

V. Swathi Pon Sakthi Sri,

Y. Aron Santhosh Kumar,

M. Savurirajan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 31, 2024

Cancer is a global issue and hence various efforts are being made. Iron oxide considered significant biochemical agent in the biomedical arena for cancer treatment. Marine macroalgae-mediated iron oxides especially, magnetite (Fe3O4) nanoparticles (NPs) prospective alternative to diagnose treat owing their fluorescent magnetic properties. We intend appraise usability of aqueous extract Rosenvingea intricata (R. intricata) Fe3O4 NPs synthesis study cytotoxic effects against human hepatocarcinoma (Hep3B) pancreatic (PANC1) cells. In present study, R. were collected from coastal region South Andaman, India. Aqueous extracts utilized synthesize via co-precipitation method. Phycosynthesized exhibited wide peak at 400–600 nm ultraviolet–visible diffused reflectance spectroscopic analysis which validated formation NPs. Band edge emission 660 spectra confirmed quantum confinement Fourier transform infrared spectroscopy role as capping reducing with functional groups such O–H, C–H, C=O, N=O, C=C, C–O, C–N, C–S arising amino acids, polysaccharides, aliphatic hydrocarbons, esters, amides, lignins, alkanes, amines, sulfates. Physicochemical properties crystallite size (14.36 nm), hydrodynamic (84.6 irregular morphology, elemental composition, particle (125 crystallinity, saturation magnetization (0.90007 emu/g) obtained x-ray diffractometer, dynamic light scattering, scanning electron microscopy, energy dispersive spectrometer, high-resolution transmission selected area diffraction vibrating sample magnetometer techniques, respectively. The cell viability showed dose-dependent enhanced apoptosis Hep3B PANC1 capped could be most appropriate effective nanomaterial treatment management.

Language: Английский

Citations

2
Recent progress in biotechnological approaches for diverse applications of algae: an overview DOI
Kandasamy Saravanakumar,

K. Sathyanarayanan,

M. S. Khan

et al.

International Journal of Environmental Science and Technology, Journal Year: 2023, Volume and Issue: 21(3), P. 3453 - 3474

Published: Dec. 15, 2023

Language: Английский

Citations

5
In vivo anticancer study of sodium 2‐[(4‐oxidobenzylidene)amino]‐6H‐1,3,4‐thiadiazine‐5‐olate against Ehrlich ascites carcinoma via targeting PI3K/mTOR pathway DOI
Youstina William Rizzk, Ibrahim M. El‐Deen, Mohammed El Behery

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(2)

Published: Jan. 23, 2024

Abstract 1,3,4‐Thiadiazine‐based components have gained the attention as they afford significant intervention for cancer therapy. We aimed at assessing in vivo antitumor activity of sodium 2‐[(4‐oxidobenzylidene) amino]‐6H‐1,3,4‐thiadiazine‐5‐c (SOTA) versus Ehrlich ascites carcinoma (EAC) cells female mice's peritoneal cavity. An advantageous interaction test compound with receptors p53 (2J1X), Caspase‐3 (3KJF), mTOR (3QAR), and PI3K (4JPS) was revealed by docking study. The study against EAC, equated EAC control mice, bearing mice that received i.p. injection proven a substantial decrease viability tumor cell 70%. Treatment tested increased total antioxidants capacity decreasing malondialdehyde levels. Also, apoptotic confirmed up regulation caspase‐3 downregulation mTOR. Through liver, kidney, heart function assessments, examined component has no adverse effects on either two organs, which were supported histological Significant positive negative associations among variables discovered, according to our research. induction apoptosis antioxidant effects, show potential anticancer cells. treatment SOTA eliminated most pathological abnormalities brought results tests well investigation. Taking together, is promising chemotherapeutic agent targeting PI3k/mTOR pathway.

Language: Английский

Citations

1