Nrf2/UBE3B protects against acute lung injury by inhibiting ferritinophagy through the ubiquitination of NCOA4 DOI Creative Commons

Yanjun Wang,

Hui Dong, Yunfan Gu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Iron overload and ferroptosis are associated with intestinal ischemia reperfusion (II/R)-induced acute lung injury (ALI). However, the mechanisms underlying regulation of iron homeostasis remain unclear. Nrf2 regulates cellular homeostasis; however, its impact on ALI pathology mechanism action requires further investigation. Ubiquitin ligase E3B (UBE3B) plays a critical role in proteasome pathway, which is essential for protein turnover ubiquitin-mediated signaling. A recent study found that UBE3B oxidative stress; it remains unknown whether related to Nrf2. Furthermore, exact largely uncharacterized. In present study, immunohistochemical analysis expression type II alveolar epithelial cells (AECII) was conducted be increased II/R-ALI. Western blot indicated hyperactivation may alleviate stress, thereby protecting against ALI. Moreover, involved metabolism dysfunction ferroptosis. deficiency enhanced process nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy ferrous ion content, whereas overexpression reversed harmful effects knockdown AECⅡ, promote AECⅡ This highlights Nrf2/UBE3B/NCOA4 axis II/R-ALI pathogenesis, suggesting activation promising strategy treatment.

Language: Английский

Glutathione Metabolism in Ferroptosis and Cancer Therapy DOI
Xiangfei Xue, Manyuan Wang, Jiangtao Cui

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217697 - 217697

Published: April 1, 2025

Language: Английский

Citations

0
Regulation of Iron Metabolism in Ferroptosis: from Mechanism Research to Clinical Translation DOI Creative Commons
Xin Zhang, Xiang Yang, Qingyan Wang

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101304 - 101304

Published: April 1, 2025

Language: Английский

Citations

0
Targeting ferroptosis for precision medicine in cervical cancer DOI

Xin Sun,

Z.K. Chen,

Hui Yang

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

Citations

0
The recent advancements of ferroptosis of gynecological cancer DOI Creative Commons

Shenglan Tang,

Li Chen

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 26, 2024

Ovarian, endometrial, and cervical cancer are the most common types of gynecologic tumor in women. Surgery, combined with radiotherapy chemotherapy, is commonly used to treat these tumors. Unfortunately, difficulties early diagnosis acquired drug resistance have resulted poor outcomes for patients. Ferroptosis a form regulated cell death that depends on iron characterized by accumulation, reactive oxygen species production, lipid peroxidation. The strong association between ferroptosis many diseases, especially has been confirmed numerous studies. Many studies demonstrated involved initiating, progressing metastasizing This review summarizes pathogenesis its development, treatment, prognosis tumors, further explore potential utility treating

Language: Английский

Citations

3
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, In Vivo Efficacy, and Safety Assessment DOI
Kaushik Kuche,

Vivek Yadav,

Meet Patel

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(7)

Published: Sept. 11, 2023

Language: Английский

Citations

7
Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance DOI Creative Commons

Yitian Sun,

Qinyi Li, Yufei Huang

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 20, 2024

Redox imbalance is reported to play a pivotal role in tumorigenesis, cancer development, and drug resistance. Severe oxidative damage general consequence of cell responses treatment may cause death or severe adverse effects. To maintain their longevity, cells can rescue redox balance enter state resistance anticancer drugs. Therefore, targeting signalling pathways has emerged as an attractive prospective strategy for enhancing the efficacy drugs decreasing Over past few decades, natural products (NPs) have become invaluable source developing new due high low toxicity. Increasing evidence demonstrated that many NPs exhibit remarkable antitumour effects, whether used alone adjuvants, are emerging effective approaches enhance sensitivity decrease effects conventional therapies by regulating balance. Among them several novel based on entered clinical trials. In this review, we summarize synergistic related mechanisms combination with We believe regulation will represent promising candidates provide prospects future.

Language: Английский

Citations

2
Ferroptosis: a novel strategy to overcome chemoresistance in gynecological malignancies DOI Creative Commons
Jing Xu, Bohao Zheng, Wei Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 9, 2024

Ferroptosis is an iron-dependent form of cell death, distinct from apoptosis, necrosis, and autophagy, characterized by altered iron homeostasis, reduced defense against oxidative stress, increased lipid peroxidation. Extensive research has demonstrated that ferroptosis plays a crucial role in the treatment gynecological malignancies, offering new strategies for cancer prevention therapy. However, chemotherapy resistance poses urgent challenge, significantly hindering therapeutic efficacy. Increasing evidence suggests inducing can reverse tumor to chemotherapy. This article reviews mechanisms discusses its potential reversing cancers. We summarized three critical pathways regulating ferroptosis: regulation glutathione peroxidase 4 (GPX4), metabolism, peroxidation pathways, considering their prospects challenges as resistance. These studies provide fresh perspective future modalities.

Language: Английский

Citations

2
Target prediction and potential application of dihydroartemisinin on hepatocarcinoma treatment DOI

Wenjia Guo,

Yue Liu, Bingdi Chen

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(10), P. 7711 - 7724

Published: May 7, 2024

Language: Английский

Citations

1
Co-delivery of doxorubicin-dihydroartemisinin prodrug/TEPP-46 nano-liposomes for improving antitumor and decreasing cardiotoxicity in B16-F10 tumor-bearing mice DOI

Qiuyue Jin,

Xiaohui Zhou, Xiaomin Niu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 113992 - 113992

Published: May 26, 2024

Language: Английский

Citations

1
Natural products targeting ferroptosis pathways in cancer therapy (Review) DOI
Na Xin, Lin Li, Dongmei Liu

et al.

Oncology Reports, Journal Year: 2024, Volume and Issue: 52(3)

Published: July 23, 2024

Language: Английский

Citations

1