Advances in Materials Science,
Journal Year:
2023,
Volume and Issue:
23(4), P. 99 - 122
Published: Dec. 1, 2023
Abstract
Carbonaceous
or
nanocarbon
nano-reinforcement
nanocomposites
have
been
found
as
emergent
candidates
for
aerospace
industry.
Consequently,
the
multifunctional
fabricated
using
marvelous
nanostructures
like
graphene,
carbon
nanotube,
fullerene,
black,
etc.
Manufacturing
techniques
also
engrossed
formation
of
high
performance
engineering
having
fine
strength,
heat
stability,
flame
resistance,
and
other
space
desired
features.
These
practices
include
solution,
in
situ,
melt
procedures,
on
top
specific
structural
design
techniques,
structures.
The
related
material
property
enhancements
various
carbonaceous
nano-reinforcements
depends
upon
type
nanocarbon,
dimensionality,
well
inherent
features
these
(in
addition
to
choice
manufacturing
methods).
Furthermore,
filled,
besides
fibers,
epoxy
matrices.
Nanocarbon
coated
fibers
filled
resins
form
nanomaterials
materials
experiential
appropriate
Further
research
may
be
a
key
towards
future
opportunities
aero
systems.
Additionally,
explorations
structure-property
relationships
indispensable
development
advanced
Gels,
Journal Year:
2023,
Volume and Issue:
9(9), P. 700 - 700
Published: Aug. 29, 2023
Sustained
release
is
highly
desired
for
"efficacious,
safe
and
convenient"
drug
delivery,
particularly
those
anticancer
molecules
with
toxicity.
In
this
study,
a
modified
coaxial
electrospraying
process
was
developed
to
coat
hydrophobic
lipid,
i.e.,
stearic
acid
(SA),
on
composites
composed
of
the
tamoxifen
citrate
(TC)
insoluble
polymeric
matrix
ethylcellulose
(EC).
Compared
electrosprayed
TC-EC
composite
microparticles
M1,
SA-coated
hybrid
M2
were
able
provide
an
improved
TC
sustained-release
profile.
The
30%
90%
loaded
time
periods
extended
3.21
h
19.43
M2,
respectively,
which
significantly
longer
than
provided
by
M1
(0.88
9.98
h,
respectively).
morphology,
inner
structure,
physical
state,
compatibility
components
particles
disclosed
through
SEM,
TEM,
XRD,
FTIR.
Based
analyses,
mechanism
multiple
factors
co-acting
suggested,
include
reasonable
selections
organizations
lipid
excipient,
blank
SA
shell
loading,
regularly
round
shape,
also
high
density.
reported
protocols
pioneered
brand-new
manner
developing
sustained
delivery
hybrids
combination
cellulose
gels
using
electrospraying.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: May 1, 2024
Abstract
The
shapes
of
micro‐
and
nano‐products
have
profound
influences
on
their
functional
performances,
which
has
not
received
sufficient
attention
during
the
past
several
decades.
Electrohydrodynamic
atomization
(EHDA)
techniques,
mainly
include
electrospinning
electrospraying,
are
facile
in
manipulate
products'
shapes.
In
this
review,
generated
using
EHDA
for
modifying
drug
release
profiles
reviewed.
These
linear
nanofibers,
round
micro‐/nano‐particles,
beads‐on‐a‐string
hybrids.
They
can
be
further
divided
into
different
kinds
sub‐shapes,
explored
providing
desired
pulsatile
release,
sustained
biphasic
delayed
pH‐sensitive
release.
Additionally,
resulted
from
organizations
electrospun
nanofibers
discussed
delivery,
inner
structures
considered
together
developing
novel
delivery
systems.
future,
related
shape–performance
relationships
at
nanoscale,
besides
size,
structure
structure–performance
relationships,
would
play
important
roles
promoting
developments
field.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Macromolecular Materials and Engineering,
Journal Year:
2023,
Volume and Issue:
309(4)
Published: Nov. 23, 2023
Abstract
In
this
study,
three
kinds
of
electrohydrodynamic
atomization
(EHDA)
processes
(electrospraying,
electrospinning,
and
coaxial
electrospinning)
are
implemented
to
create
hydroxypropyl
methylcellulose
(HPMC)
based
ultra‐thin
products
for
providing
the
fast
dissolution
a
poorly
water‐soluble
drug
ketoprofen
(KET).
An
EHDA
apparatus,
characterized
by
novel
spinneret,
is
homemade
conducting
processes.
The
types
electrospun
nanofibers
E1,
electrosprayed
microparticles
E2,
core‐shell
E3.
SEM
TEM
results
indicate
that
they
have
anticipated
morphologies
inner
structures.
X‐ray
diffraction
Fourier
Transform
Infrared
verify
KET
mainly
amorphous
in
all
composites
due
its
fine
compatibility
with
HPMC.
vitro
tests
demonstrate
rapid
release
performances
has
an
order
E3>E1>E2≫KET
powders.
mechanisms
suggested
advantages
compared.
super
performance
E3
furnishing
attributed
synergistic
action
small
size
(of
shell
thickness),
high
porosity,
state
drug,
solubility
nanostructures
can
support
development
nano
delivery
systems
(DDSs)
through
tailoring
spatial
distribution
molecules
within
products.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 15, 2023
Bacterial
prostatitis
is
a
challenging
condition
to
treat
with
traditional
dosage
forms.
Physicians
often
prescribe
variety
of
forms
different
administration
methods,
which
fail
provide
an
efficient
and
convenient
mode
drug
delivery.
The
aim
this
work
was
develop
new
type
hybrid
material
incorporating
both
electrosprayed
core-shell
microparticles
electrospun
nanofibers.
A
Chinese
medicine
(Ningmitai,
NMT)
Western
(ciprofloxacin,
CIP)
were
co-encapsulated
within
designed
be
released
in
separately
controlled
manner.
Utilizing
polyvinylpyrrolidone
(PVP)
as
hydrophilic
filament-forming
polymer
pH-sensitive
Eudragit
®
S100
(ES100)
the
particulate
polymeric
matrix,
combined
electrohydrodynamic
atomization
(EHDA)
method
comprising
coaxial
electrospraying
blending
electrospinning,
used
create
hybrids
single-step
straightforward
series
characterization
methods
conducted
analyze
working
process
its
final
products.
Scanning
electron
microscopy
transmission
revealed
that
EHDA
comprised
CIP-PVP
nanofibers
NMT-ES100
microparticles.
Multiple
confirmed
rapid
release
CIP
sustained
NMT.
antibacterial
experiments
indicated
exhibited
more
potent
effect
against
Escherichia
coli
dh5α
Bacillus
subtilis
Wb800
than
either
separate
or
amalgamation
fibrous
nanomedicine
micromedicine
can
expand
horizon
types
medicines.
integration
electrospinning
provides
approach
fabrication.
By
combining
soluble
polymers
hybrids,
we
ensure
sequential
NMT
for
potential
synergistic
therapy
bacterial
prostatitis.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 5, 2024
Diabetic
wounds
are
a
significant
subset
of
chronic
characterized
by
elevated
levels
inflammatory
cytokines,
matrix
metalloproteinases
(MMPs),
and
reactive
oxygen
species
(ROS).
They
also
associated
with
impaired
angiogenesis,
persistent
infection,
high
likelihood
hospitalization,
leading
to
substantial
economic
burden
for
patients.
In
severe
cases,
amputation
or
even
mortality
may
occur.
foot
ulcers
(DFUs)
common
complication
diabetes,
up
25%
diabetic
patients
being
at
risk
developing
over
their
lifetime,
more
than
70%
ultimately
requiring
amputation.
Electrospun
scaffolds
exhibit
structural
similarity
the
extracellular
(ECM),
promoting
adhesion,
growth,
migration
fibroblasts,
thereby
facilitating
formation
new
skin
tissue
wound
site.
The
composition
size
electrospun
can
be
easily
adjusted,
enabling
controlled
drug
release
through
fiber
structure
modifications.
porous
nature
these
facilitates
gas
exchange
absorption
exudate.
Furthermore,
surface
readily
modified
impart
specific
functionalities,
making
electrospinning
nanofiber
highly
promising
treatment
wounds.
This
article
provides
concise
overview
healing
process
in
normal
pathological
mechanisms
underlying
wounds,
including
complications
such
as
ulcers.
It
explores
advantages
treatment.
Additionally,
it
summarizes
findings
from
various
studies
on
use
different
types
reviews
methods
loading
onto
scaffolds.
These
advancements
broaden
horizon
effectively
treating
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 646 - 646
Published: April 8, 2024
Dressings
with
multiple
functional
performances
(such
as
hemostasis,
promoting
regeneration,
analgesia,
and
anti-inflammatory
effects)
are
highly
desired
in
orthopedic
surgery.
Herein,
several
new
kinds
of
medicated
nanofibers
loaded
active
ingredients
for
providing
functions
were
prepared
using
the
modified
coaxial
electrospinning
processes.
With
an
electrospinnable
solution
composed
polycaprolactone
fenoprofen
core
working
fluid,
different
types
unspinnable
fluids
(including
pure
solvent,
nanosuspension
containing
tranexamic
acid
hydroxyapatite,
dilute
polymeric
comprising
acid,
polyvinylpyrrolidone)
explored
to
implement
processes
creating
multifunctional
nanofibers.
Their
morphologies
inner
structures
assessed
through
scanning
transmission
electron
microscopes,
which
all
showed
a
linear
format
without
discerned
beads
or
spindles
diameter
smaller
than
1.0
μm,
some
them
had
incomplete
core–shell
nanostructures,
represented
by
symbol
@.
Additionally,
strange
details
about
sheaths’
topographies
observed,
included
cracks,
adhesions,
embedded
nanoparticles.
XRD
FTIR
verified
that
drugs
presented
amorphous
state,
resulted
from
fine
compatibility
among
involved
components.
All
samples
demonstrated
have
hydrophilic
property
exhibited
lower
water
contact
angle
40°
300
ms.
In
vitro
dissolution
tests
indicated
was
released
sustained
manner
over
6
h
typical
Fickian
diffusion
mechanism.
Hemostatic
intentional
distribution
on
shell
sections
able
endow
rapid
hemostatic
effect
within
60
s.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 504 - 504
Published: Feb. 12, 2024
In
the
21st
century,
chemotherapy
stands
as
a
primary
treatment
method
for
prevalent
diseases,
yet
drug
resistance
remains
pressing
challenge.
Utilizing
electrospinning
to
support
drugs
offers
sustained
and
controlled
release
methods
in
contrast
oral
implantable
delivery
modes,
which
enable
localized
of
distinct
tumor
types.
Moreover,
core–sheath
structure
bears
advantages
dual-drug
loading:
core
sheath
layers
can
carry
different
drugs,
facilitating
collaborative
counter
resistance.
This
approach
minimizes
patient
discomfort
associated
with
multiple-drug
administration.
Electrospun
fibers
not
only
transport
but
also
integrate
metal
particles
targeted
compounds,
enabling
combinations
magnetic
heat
therapies
comprehensive
cancer
treatment.
review
delves
into
preparation
techniques
tailored
various
cancers,
foreseeing
their
promising
roles
