Life,
Journal Year:
2022,
Volume and Issue:
12(5), P. 657 - 657
Published: April 29, 2022
Apart
from
ATP
generation,
mitochondria
are
involved
in
a
wide
range
of
functions,
making
them
one
the
most
prominent
organelles
human
cell.
Mitochondrial
dysfunction
is
pathophysiology
several
diseases,
such
as
cancer,
neurodegenerative
cardiovascular
and
metabolic
disorders.
This
makes
it
target
for
variety
therapeutics
diagnosis
treatment
these
diseases.
The
use
nanoparticles
to
has
significant
importance
modern
times
because
they
provide
promising
ways
deliver
drug
payloads
by
overcoming
challenges,
low
solubility
poor
bioavailability,
also
resolve
issues
biodistribution
drugs
pharmacokinetics
with
increased
specificity.
review
assesses
nanoparticle-based
drug-delivery
systems,
liposomes,
DQAsome,
MITO-Porters,
micelles,
polymeric
metal
nanocarriers,
well
quantum
dots,
mitochondria-targeted
strategies
discusses
mitochondrial
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(1), P. 131 - 131
Published: Jan. 5, 2023
Reactive
oxygen
species
(ROS)
have
been
described
to
induce
a
broad
range
of
redox-dependent
signaling
reactions
in
physiological
conditions.
Nevertheless,
an
excessive
accumulation
ROS
leads
oxidative
stress,
which
was
traditionally
considered
as
detrimental
for
cells
and
organisms,
due
the
damage
they
cause
biomolecules.
During
ageing,
elevated
levels
result
damaged
proteins,
may
exhibit
altered
enzymatic
function
or
physical
properties
(e.g.,
aggregation
propensity).
Emerging
evidence
also
highlights
relationship
between
stress
age-related
pathologies,
such
protein
misfolding-based
neurodegenerative
diseases
Parkinson’s
(PD),
Alzheimer’s
(AD)
Huntington’s
(HD)
diseases).
In
this
review
we
aim
introduce
role
physiology
pathology
then
focus
on
state-of-the-art
techniques
available
detect
quantify
oxidized
proteins
live
vivo,
providing
guide
those
aiming
characterize
ageing
diseases.
Lastly,
discuss
recently
published
data
neurological
disorders.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(5), P. 1398 - 1398
Published: May 8, 2023
Alzheimer’s
disease
(AD)
is
the
most
prominent
neurodegenerative
disorder
in
aging
population.
It
characterized
by
cognitive
decline,
gradual
neurodegeneration,
and
development
of
amyloid-β
(Aβ)-plaques
neurofibrillary
tangles,
which
constitute
hyperphosphorylated
tau.
The
early
stages
neurodegeneration
AD
include
loss
neurons,
followed
synaptic
impairment.
Since
discovery
AD,
substantial
factual
research
has
surfaced
that
outlines
disease’s
causes,
molecular
mechanisms,
prospective
therapeutics,
but
a
successful
cure
for
not
yet
been
discovered.
This
may
be
attributed
to
complicated
pathogenesis
absence
well-defined
mechanism,
constrained
diagnostic
resources
treatment
options.
To
address
aforementioned
challenges,
extensive
modeling
essential
fully
comprehend
underlying
mechanisms
making
it
easier
design
develop
effective
strategies.
Emerging
evidence
over
past
few
decades
supports
critical
role
Aβ
tau
participation
glial
cells
different
cellular
pathways.
review
extensively
discusses
current
understanding
concerning
Aβ-
tau-associated
dysfunction
AD.
Moreover,
risk
factors
associated
with
including
genetics,
aging,
environmental
variables,
lifestyle
habits,
medical
conditions,
viral/bacterial
infections,
psychiatric
have
summarized.
present
study
will
entice
researchers
more
thoroughly
explore
status
mechanism
assist
drug
forthcoming
era.
IBRO Neuroscience Reports,
Journal Year:
2024,
Volume and Issue:
16, P. 373 - 394
Published: Jan. 23, 2024
Superoxide
dismutase
(SOD)
is
a
common
antioxidant
enzyme
found
majorly
in
living
cells.
The
main
physiological
role
of
SOD
detoxification
and
maintain
the
redox
balance,
acts
as
first
line
defence
against
Reactive
nitrogen
species
(RNS),
oxygen
(ROS),
other
such
potentially
hazardous
molecules.
catalyses
conversion
superoxide
anion
free
radicals
(O
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(2), P. 240 - 240
Published: Feb. 16, 2024
Neurodegenerative
diseases
(NDs)
encompass
an
assorted
array
of
disorders
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis,
each
characterised
by
distinct
clinical
manifestations
underlying
pathological
mechanisms.
While
some
cases
have
a
genetic
basis,
many
NDs
occur
sporadically.
Despite
their
differences,
these
commonly
feature
chronic
neuroinflammation
hallmark.
Consensus
has
recently
been
reached
on
the
possibility
that
mitochondria
dysfunction
protein
aggregation
can
mutually
contribute
to
activation
neuroinflammatory
response
thus
onset
progression
disorders.
In
present
review,
we
discuss
contribution
aetiology
NDs,
highlighting
new
potential
therapeutic
targets
be
identified
tackle
neurodegenerative
processes
alleviate
pathologies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7952 - 7952
Published: July 21, 2024
Alzheimer's
disease
(AD)
and
Parkinson's
(PD)
are
the
most
common
neurodegenerative
diseases,
they
affect
millions
of
people
worldwide,
particularly
older
individuals.
Therefore,
there
is
a
clear
need
to
develop
novel
drug
targets
for
treatment
age-related
diseases.
Emerging
evidence
suggests
that
mitochondrial
dysfunction
reactive
oxygen
species
(ROS)
generation
play
central
roles
in
onset
progression
Mitochondria
key
regulators
respiratory
function,
cellular
energy
adenosine
triphosphate
production,
maintenance
redox
homeostasis,
which
essential
cell
survival.
Mitochondrial
morphology
function
tightly
regulated
by
maintaining
balance
among
fission,
fusion,
biogenesis,
mitophagy.
In
this
review,
we
provide
an
overview
main
functions
mitochondria,
with
focus
on
recent
progress
highlighting
critical
role
ROS-induced
oxidative
stress,
dysregulated
dynamics,
apoptosis,
mitochondria-associated
inflammation,
impaired
pathogenesis
such
as
AD
PD.
We
also
discuss
potential
fusion
biogenesis
enhancers,
fission
inhibitors,
mitochondria-targeted
antioxidants
drugs
these
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 24, 2025
Abstract
Free
radicals,
characterized
by
the
presence
of
unpaired
electrons,
are
highly
reactive
species
that
play
a
significant
role
in
human
health.
These
molecules
can
be
generated
through
various
endogenous
processes,
such
as
mitochondrial
respiration
and
immune
cell
activation,
well
exogenous
sources,
including
radiation,
pollution,
smoking.
While
free
radicals
essential
for
certain
physiological
signaling
defense,
their
overproduction
disrupt
delicate
balance
between
oxidants
antioxidants,
leading
to
oxidative
stress.
Oxidative
stress
results
damage
critical
biomolecules
like
DNA,
proteins,
lipids,
contributing
pathogenesis
diseases.
Chronic
conditions
cancer,
cardiovascular
diseases,
neurodegenerative
disorders,
inflammatory
diseases
have
been
strongly
associated
with
harmful
effects
radicals.
This
review
provides
comprehensive
overview
characteristics
types
mechanisms
formation,
biological
impacts.
Additionally,
we
explore
natural
compounds
extracts
studied
antioxidant
properties,
offering
potential
therapeutic
avenues
managing
radical-induced
damage.
Future
research
directions
also
discussed
advance
our
understanding
treatment
radical-associated
