Life,
Journal Year:
2022,
Volume and Issue:
12(5), P. 657 - 657
Published: April 29, 2022
Apart
from
ATP
generation,
mitochondria
are
involved
in
a
wide
range
of
functions,
making
them
one
the
most
prominent
organelles
human
cell.
Mitochondrial
dysfunction
is
pathophysiology
several
diseases,
such
as
cancer,
neurodegenerative
cardiovascular
and
metabolic
disorders.
This
makes
it
target
for
variety
therapeutics
diagnosis
treatment
these
diseases.
The
use
nanoparticles
to
has
significant
importance
modern
times
because
they
provide
promising
ways
deliver
drug
payloads
by
overcoming
challenges,
low
solubility
poor
bioavailability,
also
resolve
issues
biodistribution
drugs
pharmacokinetics
with
increased
specificity.
review
assesses
nanoparticle-based
drug-delivery
systems,
liposomes,
DQAsome,
MITO-Porters,
micelles,
polymeric
metal
nanocarriers,
well
quantum
dots,
mitochondria-targeted
strategies
discusses
mitochondrial
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(2), P. 213 - 213
Published: Jan. 23, 2022
It
is
estimated
that
the
prevalence
rate
of
Alzheimer’s
disease
(AD)
will
double
by
year
2040.
Although
currently
available
treatments
help
with
symptom
management,
they
do
not
prevent,
delay
progression
of,
or
cure
disease.
Interestingly,
a
shared
characteristic
AD
and
other
neurodegenerative
diseases
disorders
oxidative
stress.
Despite
profound
evidence
supporting
role
stress
in
pathogenesis
AD,
none
treatment
options
address
Recently,
attention
has
been
placed
on
use
antioxidants
to
mitigate
effects
central
nervous
system.
In
preclinical
studies
utilizing
cellular
animal
models,
natural
showed
therapeutic
promise
when
administered
alone
combination
compounds.
More
recently,
concept
antioxidant
therapy
explored
as
novel
approach
preventing
treating
conditions
present
contributing
factor.
this
review,
relationship
between
pathology
neuroprotective
from
sources
are
discussed.
Additionally,
potential
preventatives
and/or
for
examined,
special
paid
combinations
conjugates
being
investigated
human
clinical
trials.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11520 - 11520
Published: Oct. 26, 2021
Alzheimer’s
disease
(AD)
is
a
major
cause
of
dementia
in
older
adults
and
fast
becoming
societal
economic
burden
due
to
an
increase
life
expectancy.
Age
seems
be
the
factor
driving
AD,
currently,
only
symptomatic
treatments
are
available.
AD
has
complex
etiology,
although
mitochondrial
dysfunction,
oxidative
stress,
inflammation,
metabolic
abnormalities
have
been
widely
deeply
investigated
as
plausible
mechanisms
for
its
neuropathology.
Aβ
plaques
hyperphosphorylated
tau
aggregates,
along
with
cognitive
deficits
behavioral
problems,
hallmarks
disease.
Restoration
bioenergetics,
prevention
diet
exercise
seem
effective
reducing
ameliorating
learning
memory
problems.
Many
mitochondria-targeted
antioxidants
tested
currently
development.
However,
larger
streamlined
clinical
studies
needed
provide
hard
evidence
benefits
AD.
This
review
discusses
causative
factors,
well
potential
therapeutics
employed
treatment
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(11), P. 2167 - 2167
Published: Oct. 31, 2022
Alzheimer’s
disease
(AD),
the
most
common
form
of
dementia,
has
increasing
incidence,
mortality
rates,
and
poses
a
huge
burden
on
healthcare.
None
currently
approved
drugs
for
treatment
AD
influence
progression.
Many
clinical
trials
aiming
at
inhibiting
amyloid
plaque
formation,
beta
clearance,
or
neurofibrillary
tangle
pathology
yielded
inconclusive
results
failed.
Meanwhile,
research
identified
many
interlinked
vicious
cascades
implicating
oxidative
stress,
mitochondrial
dysfunction,
chronic
neuroinflammation,
pointed
to
novel
therapeutic
targets
such
as
improving
bioenergetics
quality
control,
diminishing
modulating
neuroinflammatory
pathways.
molecules
tested
in
vitro
animal
models
have
proven
efficient,
but
their
translation
into
clinic
needs
further
regarding
appropriate
doses,
delivery
routes,
possible
side
effects.
Cell-based
therapies
extracellular
vesicle-mediated
messenger
RNAs
microRNAs
seem
also
promising
strategies
allowing
target
specific
signaling
pathways,
need
harvesting
culture
methods
well
control
tumorigenic
The
rapidly
developing
area
nanotechnology
could
improve
drug
be
used
early
diagnosis.
Life,
Journal Year:
2022,
Volume and Issue:
12(5), P. 657 - 657
Published: April 29, 2022
Apart
from
ATP
generation,
mitochondria
are
involved
in
a
wide
range
of
functions,
making
them
one
the
most
prominent
organelles
human
cell.
Mitochondrial
dysfunction
is
pathophysiology
several
diseases,
such
as
cancer,
neurodegenerative
cardiovascular
and
metabolic
disorders.
This
makes
it
target
for
variety
therapeutics
diagnosis
treatment
these
diseases.
The
use
nanoparticles
to
has
significant
importance
modern
times
because
they
provide
promising
ways
deliver
drug
payloads
by
overcoming
challenges,
low
solubility
poor
bioavailability,
also
resolve
issues
biodistribution
drugs
pharmacokinetics
with
increased
specificity.
review
assesses
nanoparticle-based
drug-delivery
systems,
liposomes,
DQAsome,
MITO-Porters,
micelles,
polymeric
metal
nanocarriers,
well
quantum
dots,
mitochondria-targeted
strategies
discusses
mitochondrial
