Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(10), P. RCR5095 - RCR5095
Published: Aug. 28, 2023
Mitochondrial
dysfunctions
lead
to
the
emergence
and
development
of
a
large
number
diseases.
The
present
review
gives
first
systematic
survey
various
aspects
studies
mitochondria-targeted
nanosystems
containing
triphenylphosphonium
vector
groups
providing
targeted
delivery
drug
substances
these
organelles.
Approaches
design
components
nanoparticles
bearing
are
summarized
analyzed.
relationship
between
key
parameters
(chemical
composition,
size,
shape,
ζ-potential,
loading,
encapsulation
efficiency,
<i>etc</i>.)
biological
action
is
discussed;
in
some
cases,
mechanism
mitochondria
targeting
given.
principles
preparation
methods
for
interest
researchers
field
nanomaterials,
nanotechnology,
molecular
biology,
biotechnology
pharmaceutical
chemistry.
<br>
bibliography
includes
243
references.
Cellular Signalling,
Journal Year:
2023,
Volume and Issue:
109, P. 110794 - 110794
Published: July 6, 2023
Traditionally,
mitochondria
are
known
as
"the
powerhouse
of
the
cell,"
responsible
for
energy
(ATP)
generation
(by
electron
transport
chain,
oxidative
phosphorylation,
tricarboxylic
acid
cycle,
and
fatty
ß-oxidation),
regulation
several
metabolic
processes,
including
redox
homeostasis,
calcium
signalling,
cellular
apoptosis.
The
extensive
studies
conducted
in
last
decades
portray
multifaceted
signalling
organelles
that
ultimately
command
cells'
survival
or
death.
Based
on
current
knowledge,
we'll
outline
mitochondrial
to
other
intracellular
compartments
homeostasis
pathology-related
stress
conditions
here.
following
topics
discussed:
(i)
mtROS
mitohormesis,
(ii)
Ca2+
signalling;
(iii)
anterograde
(nucleus-to-mitochondria)
retrograde
(mitochondria-to-nucleus)
signal
transduction,
(iv)
mtDNA
role
immunity
inflammation,
(v)
induction
mitophagy-
apoptosis
-
cascades,
(vi)
dysfunctions
(mitochondriopathies)
cardiovascular,
neurodegenerative,
malignant
diseases.
novel
insights
into
molecular
mechanisms
mitochondria-mediated
can
explain
adaptation
environmental
stresses
achieve
cell
survival.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4300 - 4300
Published: April 12, 2024
Sarcopenia
is
a
prevalent
degenerative
skeletal
muscle
condition
in
the
elderly
population,
posing
tremendous
burden
on
diseased
individuals
and
healthcare
systems
worldwide.
Conventionally,
sarcopenia
currently
managed
through
nutritional
interventions,
physical
therapy,
lifestyle
modification,
with
no
pharmaceutical
agents
being
approved
for
specific
use
this
disease.
As
pathogenesis
of
still
poorly
understood
there
treatment
recognized
as
universally
effective,
recent
research
efforts
have
been
directed
at
better
comprehending
illness
diversifying
strategies.
In
respect,
paper
overviews
new
advances
correlation
its
underlying
mechanisms.
Specifically,
review
creates
an
updated
framework
sarcopenia,
describing
etiology,
pathogenesis,
risk
factors,
conventional
treatments,
further
discussing
emerging
therapeutic
approaches
like
drug
formulations,
delivery
systems,
stem
cell
therapies,
tissue-engineered
scaffolds
more
detail.
Journal of Clinical Medicine,
Journal Year:
2022,
Volume and Issue:
11(22), P. 6742 - 6742
Published: Nov. 14, 2022
Alzheimer's
disease
(AD),
a
chronic
and
progressive
neurodegenerative
disease,
is
characterized
by
memory
cognitive
impairment
the
accumulation
in
brain
of
abnormal
proteins,
more
precisely
beta-amyloid
(β-amyloid
or
Aβ)
Tau
proteins.
Studies
aimed
at
researching
pharmacological
treatments
against
AD
have
focused
on
molecules
capable,
one
way
another,
preventing/eliminating
accumulations
aforementioned
Unfortunately,
than
100
years
after
discovery
there
still
no
effective
therapy
modifying
biology
behind
nipping
bud.
This
state
affairs
has
made
neuroscientists
suspicious,
so
much
that
for
several
idea
gained
ground
not
direct
neuropathological
consequence
taking
place
downstream
deposition
two
toxic
but
rather
multifactorial
including
mitochondrial
dysfunction
as
an
early
event
pathogenesis
AD,
occurring
even
before
clinical
symptoms.
reason
why
search
agents
capable
normalizing
functioning
these
subcellular
organelles
vital
importance
nerve
cells
certainly
to
be
considered
promising
approach
design
neuroprotective
drugs
preserving
this
organelle
arrest
delay
progression
disease.
Here,
our
intent
provide
updated
overview
alterations
related
disorder
therapeutic
strategies
(both
natural
synthetic)
targeting
dysfunction.
IBRO Neuroscience Reports,
Journal Year:
2023,
Volume and Issue:
14, P. 407 - 418
Published: April 11, 2023
Bipolar
disorder
(BD)
is
one
of
the
major
psychiatric
diseases
in
which
impairment
mitochondrial
functions
has
been
closely
connected
or
associated
with
disease
pathologies.
Different
lines
evidence
close
connection
between
mitochondria
dysfunction
and
BD
were
discussed
a
particular
focus
on
(1)
dysregulation
energy
metabolism,
(2)
effect
genetic
variants,
(3)
oxidative
stress,
cell
death
apoptosis,
(4)
dysregulated
calcium
homeostasis
electrophysiology,
(5)
current
as
well
potential
treatments
targeting
at
restoring
functions.
Currently,
pharmacological
interventions
generally
provide
limited
efficacy
preventing
relapses
recovery
from
mania
depression
episodes.
Thus,
understanding
pathology
will
lead
to
novel
agents
formulating
new
effective
therapy
for
BD.
