Can melatonin improve the alteration of protein synthesis occurring in schizophrenia and bipolar disorder? DOI Creative Commons
Ana Coto‐Montes, Nerea Menéndez-Coto, José Antonio Boga

et al.

Melatonin Research, Journal Year: 2023, Volume and Issue: 6(1), P. 51 - 58

Published: Feb. 28, 2023

The prevalence of mental illnesses has significantly increased globally in recent decades due to multifactorial causes. Of these, schizophrenia and bipolar disorder, their high incidence associated disability, stand out. However, the effective treatments on these disorders are lagged behind incidence. Melatonin, as an essential molecule regulation sleep-wake rhythm naturally occurring antioxidant, only received attention for treatment such psychiatric relation its circadian regulation, but overwhelming role a regulator oxidative stress that facilitates amelioration neuronal damage not been addressed this respect. In communication, novel aspects melatonin have discussed. We provide necessary literature justify beneficial roles mechanisms treat disorder. These include enhances reticulum stress, potentiates unfolded protein response, increases endoplasmic synthesis facilitate autophagy even suppresses apoptosis. This process involves expected organelles is more complex cohesion includes mitochondria, well-known target melatonin, which reinforces robustness our hypothesis, i.e., prevents development aggregates abnormal structures typically observed brain damage. Its documented capacity need improve efficiency growing population afflicted by basis hypothesis support disorders.

Language: Английский

Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer’s Disease- Related Cognitive Decline DOI
Hiba Khan,

Talib Naseem,

Pooja Kaushik

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102535 - 102535

Published: Oct. 6, 2024

Language: Английский

Citations

2
Epigenetic Explorations of Neurological Disorders, the Identification Methods, and Therapeutic Avenues DOI Open Access
Zeba Firdaus, Xiaogang Li

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11658 - 11658

Published: Oct. 30, 2024

Neurodegenerative disorders are major health concerns globally, especially in aging societies. The exploration of brain epigenomes, which consist multiple forms DNA methylation and covalent histone modifications, offers new unanticipated perspective into the mechanisms neurodegenerative diseases. Initially, chromatin defects were thought to be static abnormalities from early development associated with rare genetic syndromes. However, it is now evident that mutations dysregulation epigenetic machinery extend across a broader spectrum, encompassing adult-onset Hence, crucial develop methodologies can enhance research. Several approaches have been created investigate alterations epigenetics on spectrum scales-ranging low high-with particular focus detecting modifications. This article explores burgeoning realm neuroepigenetics, emphasizing its role enhancing our mechanistic comprehension elucidating predominant techniques employed for modifications epigenome. Additionally, we ponder potential influence these advancements shaping future therapeutic approaches.

Language: Английский

Citations

2
Inserting Pre-analytical Chromatographic Priming Runs Significantly Improves Targeted Pathway Proteomics with Sample Multiplexing DOI
Steven R. Shuken, Qing Yu, Steven P. Gygi

et al.

Journal of Proteome Research, Journal Year: 2024, Volume and Issue: 23(5), P. 1834 - 1843

Published: April 10, 2024

GoDig, a platform for targeted pathway proteomics without the need manual assay scheduling or synthetic standards, is powerful, flexible, and easy-to-use method that uses tandem mass tags to increase sample throughput up 18-fold relative label-free methods. Though protein-level success rates of GoDig are high, peptide-level more limited, hampering assays harder-to-quantify proteins site-specific phenomena. To guide optimization as well improvements platform, we created GoDigViewer, new stand-alone software provides detailed visualizations runs. GoDigViewer guided implementation "priming runs," an acquisition mode with significantly higher rates. In this mode, two chromatographic priming runs automatically performed improve accuracy precision target elution orders, followed by analytical which quantify targets. Using runs, exceeded 97% list 400 peptide targets 95% 200 usually not quantified using untargeted spectrometry. We used establish quantitative 125 macroautophagy had >95% rate revealed differences in expression profiles across four human cell lines.

Language: Английский

Citations

1
Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline DOI Open Access

Aida Adlimoghaddam,

Fariba Fayazbakhsh, Mohsen Mohammadi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Abstract Macroautophagy and mitophagy are critical processes in Alzheimer’s disease (AD), yet their links to behavioral outcomes, particularly sex-specific differences, not fully understood. This study investigates autophagy (LC3B-II, SQSTM1) (BNIP3L, BNIP3, BCL2L13) markers the cortex hippocampus of male female 3xTg-AD mice, using western blotting, transmission electron microscopy (TEM), tests (novel object recognition novel placement). Significant differences emerged: mice exhibited autophagosome accumulation due impaired degradation cortex, while males showed fewer autophagosomes, especially hippocampus, without significant changes. TEM analyses demonstrated variations mitochondrial mitophagosome numbers correlated with memory outcomes. Females had enhanced mitophagy, higher BNIP3L BCL2L13 levels, whereas elevated BNIP3 dimers. Cognitive deficits females dysfunction males, LC3B-II levels associated positively cognitive performance, suggesting protective effects. Using machine learning, we predicted based on data, pioneering a predictive approach cellular outcomes AD. These findings underscore importance regulation AD support personalized therapeutic approaches targeting these pathways. Integrating learning emphasizes its potential advance neurodegenerative research. Figure Graphical Sex-specific (AD) highlighted. Female show deficits, exhibit behavior.

Language: Английский

Citations

1
Can melatonin improve the alteration of protein synthesis occurring in schizophrenia and bipolar disorder? DOI Creative Commons
Ana Coto‐Montes, Nerea Menéndez-Coto, José Antonio Boga

et al.

Melatonin Research, Journal Year: 2023, Volume and Issue: 6(1), P. 51 - 58

Published: Feb. 28, 2023

The prevalence of mental illnesses has significantly increased globally in recent decades due to multifactorial causes. Of these, schizophrenia and bipolar disorder, their high incidence associated disability, stand out. However, the effective treatments on these disorders are lagged behind incidence. Melatonin, as an essential molecule regulation sleep-wake rhythm naturally occurring antioxidant, only received attention for treatment such psychiatric relation its circadian regulation, but overwhelming role a regulator oxidative stress that facilitates amelioration neuronal damage not been addressed this respect. In communication, novel aspects melatonin have discussed. We provide necessary literature justify beneficial roles mechanisms treat disorder. These include enhances reticulum stress, potentiates unfolded protein response, increases endoplasmic synthesis facilitate autophagy even suppresses apoptosis. This process involves expected organelles is more complex cohesion includes mitochondria, well-known target melatonin, which reinforces robustness our hypothesis, i.e., prevents development aggregates abnormal structures typically observed brain damage. Its documented capacity need improve efficiency growing population afflicted by basis hypothesis support disorders.

Language: Английский

Citations

2