An Exploratory Evaluation of a Tablet-based Tool to Detect Mild Cognitive Impairment in Older Adults (Preprint) DOI
Josephine McMurray, AnneMarie Levy,

W. S. Pang

et al.

Published: Jan. 29, 2024

BACKGROUND With the rapid aging of global population, prevalence mild cognitive impairment (MCI) and dementia is anticipated to surge worldwide. MCI serves as an intermediary stage between normal dementia, necessitating more sensitive effective screening tools for early identification intervention. The BrainFx SCREEN a novel digital tool designed assess impairment. This study evaluated its efficacy in primary care settings, particularly context population growing integration health solutions. OBJECTIVE objective was validity, reliability, applicability (hereafter, SCREEN) context. We conducted exploratory comparing with established tool, Quick Mild Cognitive Impairment (Qmci) screen. METHODS A concurrent mixed methods, prospective using quasi-experimental design 147 participants from 5 Family Health Teams (FHTs; characterized by multidisciplinary practice capitated funding) across southwestern Ontario, Canada. Participants included practitioners, patients, FHT administrative executives. Individuals aged ≥55 years no history or diagnosis rostered participating were eligible participate. screened both Qmci. also incorporated Geriatric Anxiety Scale–10 general anxiety levels at each screening. SCREEN’s scoring compared against that Qmci clinical judgment professionals. Statistical analyses sensitivity, specificity, internal consistency, test-retest reliability assessments. RESULTS found longer administration time complex algorithm, which proprietary unavailable independent analysis, presented challenges. Its indicated Cronbach α 0.63, below acceptable threshold. showed limitations, moderate intraclass correlation coefficient (0.54) inadequate κ (0.15) values. Sensitivity specificity consistent (63.25% 74.07%, respectively) cross-tabulation discrepant analysis. In addition, faced limitations due demographic skew (96/147, 65.3% female, well-educated participants), absence comprehensive <i>gold standard</i> diagnosis, financial constraints limiting inclusion confirmatory neuropsychological testing. CONCLUSIONS SCREEN, current form, does not meet necessary criteria optimal primarily lower reliability. As number technologies increases evolves, further testing refinement such are essential ensure their real-world settings. advocates continued research this rapidly advancing field better serve population. CLINICALTRIAL

INTERNATIONAL REGISTERED REPORT RR2-10.2196/25520

Language: Английский

Early detection and management of hearing loss to reduce dementia risk in older adults with mild cognitive impairment: findings from the treating auditory impairment and cognition trial (TACT) DOI Creative Commons
Ruan‐Ching Yu, Menelaos Pavlou, Anne GM Schilder

et al.

Age and Ageing, Journal Year: 2025, Volume and Issue: 54(1)

Published: Jan. 1, 2025

Age-related hearing loss and mild cognitive impairment (MCI) independently increase dementia risk. The Ageing Cognitive Health Evaluation in Elders randomised controlled trial (RCT) found aids reduce decline high-risk older adults with poor hearing. This pilot RCT London memory clinics people MCI (aged ≥55, untreated defined as Pure Tone Average 0.5-4 KHz between 25-70 dB) into two groups. intervention group received 4 sessions of aid fitting support. control healthy ageing education a GP letter recommending audiological referral. Both were followed for 6 months. Primary outcomes recruitment (feasibility target: 50%; 95% CI: 39%-61%) retention 80%; 71%-89%); completion (≥2 visits) use (acceptability 71%-89%) the 50% difference arms (95% 31%-69%). Secondary included fitting, cognition other measures. From October 2018 to March 2020, 58 participants recruited (29 per group, [86%-99%]). Twenty-four fitted arm, arm (difference: 62% [42%-82%]). At months, was 81% [69%-90%]. Hearing achieved by 24 (83%). Daily reported 18 (75%) versus 5 (22%) participants, 53% [29%-77%]. Randomisation personalised is feasible. These findings support proceeding fully-powered multicentre RCT.

Language: Английский

Citations

2
Sleep fragmentation and hypoxaemia as key indicators of cognitive impairment in patients with obstructive sleep apnoea DOI Creative Commons
Thomas Georgeson,

Lacey Atkins,

Alex Zahnleiter

et al.

Sleep Science and Practice, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 10, 2025

This study aimed to identify characteristics associated with cognitive impairment in older individuals obstructive sleep apnoea (OSA) using the Addenbrooke's Cognitive Examination-Revised (ACE-R) that could aid stratifying those at higher risk for impairment. We analysed existing cross-sectional datasets measured performance of 89 adult patients (aged 50–85 years) OSA on ACE-R test. Receiver operating characteristic curves and logistic regression analysis were utilised associations between status various factors, including demographic characteristics, self-reported sleepiness, complaints, severity. According established thresholds (ACE-R ≤ 88), 36% participants cognitively impaired. When adjusted age education, strongest factors prior measures arousal index (cut-off: ≥28events/hr, OR: 5.67, p < 0.01), mean SpO2 ≤92%, 3.52, 0.05), 3% oxygen desaturation ≥27events/hr, 3.75, time spent under 90% ≥9%, 3.16, 0.05). Combining these achieved a high sensitivity (≥ 93%) detecting within this cohort. Conversely, apnoea-hypopnoea index, daytime complaints not status. The identified significant proportion as having Traditional indices fragmentation hypoxaemia may allow clinicians at-risk evaluation, however further studies are needed validate findings explore whether poor can be remediated via treatment.

Language: Английский

Citations

1
Systematic review and meta-analysis on the prevalence and risk factors of oral frailty among older adults DOI Creative Commons
Pingping Huang,

Linjing Wu,

R. Y. Zhang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Objectives The present study aim to systematically review the prevalence and influencing factors of oral frailty in older people. Methods A search strategy was developed implemented literature across PubMed, Embase, Web Science, MEDLINE (via EBSCOhost), CINAHL, Cochrane Library, Scopus, China Knowledge Resource Integrated Database (CNKI), Wanfang Data, Chinese Biomedical (CBM), Weipu (VIP), accordance with PRISMA 2020 guidelines. Our encompassed studies published up June 28, 2024, that investigated or risk among adults. Literature screening, data extraction, quality assessment were independently performed by two researchers, followed analysis using Stata 17 software. This has been registered PROSPERO. Results total 35 involving 202,864 participants analyzed. overall adults 34.0% (95% CI: 27.9–40.1%, I 2 = 99.7%, p &lt; 0.001). Subgroup analyses revealed statistically significant differences different tools age groups ( 0.05). Univariate meta-regression indicated related heterogeneity Factors such as age, gender, physical frailty, pre-frailty, unattached identified key for (all Conclusion incidence is notably high influenced a variety factors. Healthcare professionals are encouraged actively implement preventive treatment measures addressing controllable associated frailty. Such proactive efforts essential early identification high-risk individuals, which can help reduce enhance their life. Systematic Review Registration PROSPERO (CRD42023488653: https://www.crd.york.ac.uk/prospero/ ).

Language: Английский

Citations

1
Effects of Dance-Based Aerobic Training on Frailty and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial DOI Creative Commons

Marcelina Sánchez-Alcalá,

Agustín Aibar‐Almazán, María del Carmen Carcelén‐Fraile

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 351 - 351

Published: Feb. 3, 2025

Background/Objectives: The purpose of this study has been to evaluate the effects a dance-based aerobic training program on frailty, cognitive impairment, executive functions, and verbal fluency in older adults with mild impairment. Methods: Randomized clinical trial, whose sample was made up 92 adults, which 47 performed rhythmic physical activity for 12 weeks. Data frailty were collected through FRAIL, function Mini-Mental State Examination (MMSE), impairment Montreal Cognitive Assessment (MoCA), using Isaac test, functions Trail Making Test (TMT). All variables measured before after intervention by an independent researcher blinded treatment. Results: Participants experimental group showed statistically significant improvements (Cohen’s d = 0.60), 0.98), 1.22), 0.61) 0.64). Conclusions: This demonstrated that 12-week can significantly reduce improve abilities These suggest is not only effective terms health, but also promoting mental health general well-being.

Language: Английский

Citations

1
The prognosis of mild cognitive impairment: A systematic review and meta‐analysis DOI Creative Commons
Simone Salemme, Flavia Lombardo, Eleonora Lacorte

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

Abstract INTRODUCTION Knowledge gaps remain about the prognosis of mild cognitive impairment (MCI). Conversion rates to dementia vary widely, and reversion normal cognition has gained attention. This review updates evidence on MCI conversion risk probability stability reversion. METHODS We searched databases for studies with ≥3 years follow‐up, established criteria dementia, performed a meta‐analysis using random‐effects model assess risk, reversion, probability. Meta‐regressions identified sources heterogeneity guided subgroup analysis. RESULTS From 89 (mean follow‐up: 5.2 years), was 41.5% (38.3%–44.7%) in clinical 27.0% (22.0%–32.0%) population‐based studies, Alzheimer's as most common outcome. Stability were 49.3% (clinical) 49.8% (population). Reversion 8.7% 28.2% DISCUSSION Our findings highlight higher settings 30% population calling sustainable care pathway development. Highlights Prognosis (MCI) varies by setting; is lower clinical‐based studies. In both settings, ≈50%. A reorganization health services could ensure individuals MCI. Significant impacts data interpretation; follow‐up length crucial. Long‐term low‐ middle‐income countries are urgently needed.

Language: Английский

Citations

1
Machine learning algorithms to predict mild cognitive impairment in older adults in China: A cross-sectional study DOI
Yanliqing Song, Quan Yuan,

Haoqiang Liu

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

4
Efficacy of wooden toy training in alleviating cognitive decline in elderly individuals with cognitive impairment: A cluster randomized controlled study DOI Creative Commons
Qiuping Cheng,

Hanqian Wang,

M J Cui

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0309685 - e0309685

Published: Oct. 15, 2024

With the increasing global aging population, health and welfare of elderly individuals, especially individuals with prevalent mild cognitive impairment (MCI) living in nursing homes, have become critical concerns. These concerns highlight urgency developing effective interventions to address psychological needs ensuring their well-being alleviating burden on caregivers.

Language: Английский

Citations

4
Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States DOI Creative Commons
Chan Shen, Hao Wang,

Arthur Nguimatsa Djiotsop

et al.

SAGE Open Medicine, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Background: Sleep is a multifaceted phenomenon influenced by both duration and quality. Various sleep disturbances have been associated with mild cognitive impairment, but the role of specific in impairment pathophysiology remains unclear. This study investigated associations between distinct adults aged 50 older using nationally representative data. Methods: Longitudinal data from Health Retirement Study were analyzed to explore association three types disturbances: trouble falling asleep, waking up, up too early. Logistic regression models estimated unadjusted (Model 1) adjusted accounting for sex, race/ethnicity, age, social determinants health 2), general 3), depression 4), pain physical activity 5). Results: The cohort included 8877 participants ⩾50 years 2018 (baseline) who followed 2020. Overall, 15.4% reported 23.2% 12.8% early being unable fall back asleep most time. Among adults, approximately 13.1% experiencing impairment; prevalence was even higher those experienced disturbances. odds ratio (uOR) time 1.69 (95% CI: 1.42–2.03), 1.31 1.10–1.57), 1.88 1.51–2.35). However, these positive attenuated depending on covariate adjustment. Conclusions: Nearly one seven had impairment. relationship has challenging delineate. Our findings demonstrate although sensitive adjustments. These suggest pathways reducing risk

Language: Английский

Citations

0
Effects of a Loosening Meditation Practice on Older Adults With Mild Cognitive Impairment: A Pilot Study DOI Open Access
Yoshinori Kajimoto, Shinobu Tamura,

Kosuke KAWAMURA

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Background Holistic medical practices, including meditation and mindfulness, are increasingly recognized for their benefits in mental health stress reduction, with applications clinical settings. However, effects on older adults mild cognitive impairment (MCI) remain underexplored. This study aimed to evaluate the impact of loosening meditation, a brief accessible practice we developed, this population. Methods Nine MCI, defined by Mini-Mental State Examination (MMSE) scores 21-28 during screening period, participated pilot study. The sessions our were conducted weekly over four weeks. Cognitive function was assessed using MMSE Revised Hasegawa's Dementia Scale (HDS-R), while psychological well-being evaluated 30-item General Health Questionnaire (GHQ-30) Japanese version University Wales Institute Science Technology Mood Adjective Checklist (JUMACL). Serum levels representative biomarkers measured before after first session. Results Participants had mean age 78.1 years (± 4.8 years) score 25.1 points 2.5). These participants could complete all safely. No significant differences observed MMSE, HDS-R, GHQ-30, or JUMACL (tension arousal) intervention. (emotion significantly improved fourth session (pre-first, 25.3 ± 6.2; post-fourth, 28.7 7.3; p = 0.004). Among these biomarkers, serum cortisol decreased following (before versus after, 10.8 5.8 7.4 2.3 μg/dl; 0.04). Additionally, although not statistically significant, there trend towards lower level adrenaline 0.057 0.026 0.050 0.027 ng/ml; 0.06). Conclusions Our feasible, acceptable, safe, might enhance mood reduce even MCI. preliminary findings suggest its potential as supportive intervention

Language: Английский

Citations

0
Exploring health and social care preferences for people with dementia and mild cognitive impairment: a systematic review of discrete choice experiments DOI Creative Commons
N. Morrish, Chris Fox, Joanne Reeve

et al.

Aging & Mental Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: March 17, 2025

Objectives Dementia is associated with behaviour change, and impaired ability to remember think. This review focuses on key findings methodological processes from discrete choice experiments (DCEs) inform health social care interventions for people living dementia or mild cognitive impairment.

Language: Английский

Citations

0