Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

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The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr−/−;hApoB100+/+ mice

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

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Senolytic elimination of senescent cells improved periodontal ligament stem cell-based bone regeneration partially through inhibiting YAP

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119921 - 119921

Published: Feb. 18, 2025

Language: Английский

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Sex, senescence, senolytics, and cognition

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 4, 2025

This review focuses on sexual dimorphism in cellular senescence and senolytic treatment relation to brain health age-related cognitive decline. The stressors of aging, DNA damage, inflammation, oxidative stress induce cell senescence, a hallmark aging. Senescent cells change their function molecular profile are primed release pro-inflammatory cytokines. functional changes include the activation signals prevent death. cytokines from peripheral senescent during middle age induces neighbor heightens level systemic contributing neuroinflammation. In response neuroinflammation stress, some neurons alter physiology, decreasing neuronal excitability synaptic transmission. neurophysiology is protective against death due excitotoxicity, at expense loss normal function, inflammation may underlie prevalence, symptoms, pathogenesis diseases, including neurodegenerative diseases. Sex differences have been observed for astrocytes, microglia, cells, those involved innate adaptive immune responses. Interventions that remove such as drugs, can reduce or ameliorate aging-related function. Similarities responses males females depend system examined, regimen, burden, when initiated. Estrogen impacts several these factors influences transcription genes promoting growth, proliferation, survival programs manner opposite drugs. addition, estrogen has anti-aging effects independent rapidly modifying neurophysiology. Thus, it important recognize that, addition sex there other sexually dimorphic mechanisms contribute aging process. results indicate senolytics interact with fundamental biology, hormones.

Language: Английский

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Emerging insights in senescence: pathways from preclinical models to therapeutic innovations

npj Aging, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 22, 2024

Abstract Senescence is a crucial hallmark of ageing and significant contributor to the pathology age-related disorders. As committee members young International Cell Association (yICSA), we aim synthesise recent advancements in identification, characterisation, therapeutic targeting senescence for clinical translation. We explore novel molecular techniques that have enhanced our understanding senescent cell heterogeneity their roles tissue regeneration pathology. Additionally, delve into vivo models senescence, both non-mammalian mammalian, highlight tools available advancing contextual senescence. Furthermore, discuss innovative diagnostic senotherapeutic approaches, emphasising potential application. Future directions research are explored, underscoring need precise, context-specific classification integration advanced technologies such as machine learning, long-read sequencing, multifunctional senoprobes senolytics. The dual role promoting homoeostasis contributing chronic diseases highlights complexity these cells improved outcomes.

Language: Английский

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Effect of senolytic drugs in young female mice chemically induced to estropause

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123073 - 123073

Published: Sept. 1, 2024

Language: Английский

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