Adenotonsillectomy for Snoring and Mild Sleep Apnea in Children

JAMA, Journal Year: 2023, Volume and Issue: 330(21), P. 2084 - 2084

Published: Dec. 5, 2023

Importance The utility of adenotonsillectomy in children who have habitual snoring without frequent obstructive breathing events (mild sleep-disordered [SDB]) is unknown. Objectives To evaluate early compared with watchful waiting and supportive care (watchful waiting) on neurodevelopmental, behavioral, health, polysomnographic outcomes mild SDB. Design, Setting, Participants Randomized clinical trial enrolling 459 aged 3 to 12.9 years an apnea-hypopnea index (AHI) less than enrolled at 7 US academic sleep centers from June 29, 2016, February 1, 2021, followed up for 12 months. Intervention were randomized 1:1 either (n = 231) or 228). Main Outcomes Measures 2 primary changes baseline months caregiver-reported Behavior Rating Inventory Executive Function (BRIEF) Global Composite (GEC) T score, a measure executive function; computerized test attention, the Go/No-go (GNG) d-prime signal detection reflecting probability response target vs nontarget stimuli. Twenty-two secondary included 12-month quality life, sleep, health outcomes. Results Of 458 participants analyzed sample (231 237 waiting; mean age, 6.1 years; 230 female [50%]; 123 Black/African American [26.9%]; 75 Hispanic [16.3%]; median AHI, 0.5 [IQR, 0.2-1.1]), 394 (86%) completed follow-up visits. There no statistically significant differences change between groups function (BRIEF GEC T-scores: −3.1 −1.9 difference, −0.96 [95% CI, −2.66 0.74]) attention (GNG scores: 0.2 0.1 0.05 −0.18 0.27]) Behavioral problems, sleepiness, symptoms, life each improved more waiting. Adenotonsillectomy was associated greater decline systolic diastolic blood pressure percentile levels (difference changes, −9.02 [97% −15.49 −2.54] −6.52 −11.59 −1.45], respectively) progression AHI events/h (1.3% group 13.2% group; −11.2% −17.5% −4.9%]). Six (2.7%) experienced serious adverse event adenotonsillectomy. Conclusions In SDB, adenotonsillectomy, waiting, did not significantly improve However, had outcomes, including behavior, decreased pressure, follow-up. Trial Registration ClinicalTrials.gov Identifier: NCT02562040

Language: Английский

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Human REM sleep recalibrates neural activity in support of memory formation

Science Advances, Journal Year: 2023, Volume and Issue: 9(34)

Published: Aug. 25, 2023

The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation neural activity at both synaptic and whole-network levels. Now, there is a lack in vivo data humans elucidating if, how, sleep its varied stages balance activity, if such recalibration benefits memory. We combined electrophysiology with two-photon calcium imaging rodents as well intracranial scalp electroencephalography (EEG) to reveal key role for non-oscillatory brain during rapid eye movement (REM) mediate population dynamics. extent this REM predicted success consolidation, expressly modulation hippocampal-neocortical favoring remembering rather than forgetting. findings describe mechanism how human modulates enhance long-term

Language: Английский

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Recovering object-location memories after sleep deprivation-induced amnesia

Current Biology, Journal Year: 2022, Volume and Issue: 33(2), P. 298 - 308.e5

Published: Dec. 27, 2022

It is well established that sleep deprivation after learning impairs hippocampal memory processes and can cause amnesia. unknown, however, whether leads to the loss of information or merely suboptimal storage difficult retrieve. Here, we show object-location memories formed under conditions be successfully retrieved multiple days following training, using optogenetic dentate gyrus (DG) engram activation treatment with clinically approved phosphodiesterase 4 (PDE4) inhibitor roflumilast. Moreover, combination DG roflumilast treatment, 2 training deprivation, made more persistently accessible for retrieval even several later (i.e., without further pharmacological manipulation). Altogether, our studies in mice demonstrate does not necessarily but instead cannot drug stimulation. Furthermore, findings suggest memories, consolidated thought lost, again episode, PDE4

Language: Английский

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Association between sleep duration and psychological resilience in a population-based survey: A cross-sectional study

Journal of Education and Health Promotion, Journal Year: 2024, Volume and Issue: 13(1)

Published: Feb. 1, 2024

BACKGROUND: The study aimed to find out the association between sleep duration and psychological resilience in a population-based survey. MATERIALS AND METHODS: A cross-sectional survey was conducted August 2022, employing cluster random sampling method recruit community residents at Futian District Shenzhen, China. total of 2,445 participants aged 18 years over were included study. Brief Resilience Scale (BRS) utilized measure resilience, classified according American Heart Association’s categories. Multivariable linear regression used analyze relationship after adjusting for gender, age, smoking status, physical exercise frequency, body mass index (BMI), education level. RESULTS: displayed moderate levels with mean score 3.46 (standard deviation [SD] = 0.62) 7.04 h (SD 1.10). After covariates, longer associated higher (β 0.047, P < 0.05), indicating that long had scores than those short duration. CONCLUSION: Longer is positively residents. These findings suggest improving may be promising approach enhancing preventing problems, promoting overall mental health development.

Language: Английский

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The function of sleep and the treatment of primary insomnia

Deutsches Ärzteblatt international, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 6, 2023

Good sleep is correlated with health. Primary insomnia a common reason for consulting primary care physician. It usually treated drugs despite clear evidence the efficacy of behavioral therapy.

Language: Английский

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The Impact of Sleep on Sensory Processing in Typically Developing Children: Insights from Cross-Sectional and Longitudinal Data

Children, Journal Year: 2025, Volume and Issue: 12(2), P. 153 - 153

Published: Jan. 28, 2025

Background/Objectives: Previous research suggests that sleep quality and duration may significantly impact sensory experiences, yet the specific relationships in healthy early childhood remain unclear. This study explores relationship between parameters processing outcomes typically developing children followed longitudinally from 3 to 12 months 4 years of age. Methods: We assessed problems, duration, onset latency, parasomnias, a sample (N = 85). Sleep were reported by parents, was evaluated using Sensory Processing Measure—Parent version (SPM-P). Cross-sectional longitudinal analyses examined predictors based on patterns at 3–12 months, 18 2 years, Results: Our findings indicate greater problems correlate with heightened sensitivity across modalities, including touch vision, as well higher-order cognitive functions such planning social interactions. Specifically, significant while predicted skills. Additionally, longer during infancy (3–12 months) positively influenced participation years. Conclusions: underscores critical role shaping childhood. Promoting habits mitigate difficulties, ultimately supporting emotional development.

Language: Английский

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During COVID: Who slept better? Who slept worse? Recommendations for sleep frailty and sleep robustness

MOJ Public Health, Journal Year: 2025, Volume and Issue: 14(1), P. 14 - 19

Published: Jan. 1, 2025

COVID 19 pandemic had worldwide negative repercussions. The overall prevalence of sleep disorders during Covid was around 40%, with differences according to specific populations, more vulnerable or greater exposure. Since is a fundamental pillar health and essential for survival physical mental it know what preserves deteriorates in adverse situations. Objectives: Comparison those who slept better, equal worse, using multimodal ecologic model. Methods: Sleep Quality Awakening quality before the were used as referential measures. Analysis variance quantitative variables pre-COVID stress performed, linear discriminant analysis (LDA) applied classify 3 groups: Worse, Equal Better. Results: Despite many statistical between groups, LDA discrimination subgroups ranged globally from 70 86%. Using Worse group correctly classified high correctness, 74.3 97.3%; classification 67.1 97.7%; Better however low values (25.7 27.9%). achieved higher Quality. Conclusion: results are discussed recommendations focused on you should not do, avoid poor conditions.

Language: Английский

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Beyond Bouncing Back: Exploring Undergraduate Dental Professional Students' Perceptions of Resilience

International Journal of Dental Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

ABSTRACT Introduction The first signs of mental health issues in dentistry manifest as early undergraduate training, thus it is essential to delve into the concept resilience equip those studying and working with resources cultivate a positive mindset. Materials Methods A focus group was conducted homogenous purposive sample eight dental profession students from all 3 years study at University Portsmouth Dental Academy (UPDA). six‐phase Braun Clarke's thematic analysis adopted interpret patterns data. Results Four themes of: ‘definition resilience’; ‘factors enhancing challenging resilience’ ‘developing dentistry’; 23 subthemes were identified. Students defined an ability bounce back adversity perceived dynamic contextual phenomenon that fluctuated due interplay personal, social environmental factors. Conclusion findings this showed students' perceptions resilience, factors influencing strategies develop it. These may inform curriculum training programmes targeted towards population.

Language: Английский

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Reactivation of memory-associated neurons induces downstream suppression of competing neuronal populations

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(14)

Published: April 1, 2025

Inducing apparent memory recall by tagging and optogenetically reactivating cells in the hippocampus was demonstrated over a decade ago. However, hippocampal dynamics resulting from this reactivation remain largely unknown. While calcium imaging is commonly used as measure of neuronal activity, GCaMP, most common indicator, cannot be with optogenetic because both require blue light excitation. To resolve overlap, we demonstrate red-shifted opsin, ChrimsonR. We then conduct dual-color CA1 during DG. In addition to measuring population CA1, tagged original experience were identified. fear-conditioned animals (FC+), nontagged decreased their firing rate stimulation, while maintained activity level. FC+ animals, behavioral effect stimulation across days, so did changes neural stimulation. Our results technical feasibility memory-associated neurons advance our understanding underlying reactivation.

Language: Английский

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Implications of Poor Sleep on Synaptic Plasticity, Memory Consolidation, and Decision-Making in Military Populations

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Abstract This chapter reviews sleep and cognitive plasticity in the context of military applications. Sleep is critical to learning decision-making for warfighter, at synaptic level function are shown be inextricably intertwined. Understanding physiological biochemical aspects can promote targeted mitigation strategies conserve optimize a unit’s fighting strength under operational conditions that may induce restriction, deprivation, circadian disruption. involves reduction responsiveness central nervous system networks render conscious thought actions response environmental contingencies. Since overt symptoms associated with deprivation also seen fatigue trauma memories, both which common operations, these phenomena will contrasted such leader apply remediation appropriate underlying causes impaired performance. Finally, performance optimization from an lens does not always lead health conserving strength, warranting careful consideration trade-offs.

Language: Английский

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