The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases DOI Creative Commons
Robin Bonomi,

William Riordan,

Juri G. Gelovani

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1644 - 1644

Published: Oct. 2, 2024

Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology medicine. One key mechanism involves acetylation deacetylation of lysine residues on histone core proteins other critical that regulate gene expression cellular signaling. Although deacetylases (HDACs) have received significant attention, roles individual HDAC isoforms pathogenesis psychiatric diseases still require further research. This is particularly true with regard to sirtuins, class III HDACs. Sirtuins unique functional activity normal neurophysiology, as well mechanisms addiction, mood disorders, neuropsychiatric abnormalities. review aims elucidate differences catalytic structure function seven sirtuins they relate psychiatry.

Language: Английский

Effects of association between resveratrol and ketamine on behavioral and biochemical analysis in mice DOI

Patrícia Zorzi Juliani,

Talita Rodrigues,

Getúlio Nicola Bressan

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 971 - 986

Published: June 14, 2024

Language: Английский

Citations

2
Nature and nurture: Comparing mouse behavior in classic versus revised anxiety‐like and social behavioral assays in genetically or environmentally defined groups DOI Creative Commons

Janet Ronquillo,

Michael Nguyen,

Linnea Y. Rothi

et al.

Genes Brain & Behavior, Journal Year: 2023, Volume and Issue: 22(6)

Published: Oct. 23, 2023

Widely used rodent anxiety assays like the elevated plus maze (EPM) and open field test (OFT) are conflated with rodents' natural preference for dark over light environments or protected spaces. The EPM OFT have been decades but often criticized by behavioral scientists. Years ago, two revised were designed to improve upon "classic" tests excluding possibility avoid escape aversion. 3-D radial arm (3DR) (3Doft) utilize continual motivational conflict better model anxiety; each consist of an space connected ambiguous paths toward uncertain escape. Despite their utility, not caught on. This could be because no study yet has directly compared classic in same animals. To remedy this, we contrasted behavior from a battery (EPM, OFT, 3DR, 3Doft sociability test) mice defined genetically isogenic strain, environmentally postnatal experience. One major motivation this work is inform future studies offering transparent look at individual outcomes on these assays, as there one-size-fits-all assess anxiety-like behavior. Findings suggest that may sufficiently characterize differences across groups, 3DR advantageous investigating more nuanced such those stemming environmental factors. Finally, exposure multiple significantly affected sociability, highlighting concerns designing interpreting batteries tests.

Language: Английский

Citations

6
Interaction between resveratrol and SIRT1: role in neurodegenerative diseases DOI
Lin Zhu, Miaomiao Yang,

Lehao Fan

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 89 - 101

Published: Aug. 6, 2024

Language: Английский

Citations

1
Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets? DOI Creative Commons
Alfonso Martone, Chiara Possidente, Giuseppe Fanelli

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Treatment response and resistance in major depressive disorder (MDD) show a significant genetic component, but previous studies had limited power also due to MDD heterogeneity. This literature review focuses on the factors associated with treatment outcomes MDD, exploring their overlap those clinically relevant symptom dimensions. We searched PubMed for: (1) genome-wide association (GWASs) or whole exome sequencing (WESs) that investigated efficacy MDD; (2) examining between specific dimensions; (3) GWASs of identified 13 one WES reporting several loci, genes, gene sets involved expression, immune system regulation, synaptic transmission plasticity, neurogenesis differentiation. Nine dimensions were poor studied by (anxiety, neuroticism, anhedonia, cognitive functioning, melancholia, suicide attempt, psychosis, sleep, sociability). Four genes both these dimensions: CGREF1 (anxiety); MCHR1 (neuroticism); FTO NRXN3 (sleep). Other overlapping signals found when considering suggestively outcomes. Genetic showed convergence at level biological processes, despite no replication variant level. The interest may point shared mechanisms potential targets for new treatments tailored individual patient’s clinical profile.

Language: Английский

Citations

1
The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases DOI Creative Commons
Robin Bonomi,

William Riordan,

Juri G. Gelovani

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1644 - 1644

Published: Oct. 2, 2024

Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology medicine. One key mechanism involves acetylation deacetylation of lysine residues on histone core proteins other critical that regulate gene expression cellular signaling. Although deacetylases (HDACs) have received significant attention, roles individual HDAC isoforms pathogenesis psychiatric diseases still require further research. This is particularly true with regard to sirtuins, class III HDACs. Sirtuins unique functional activity normal neurophysiology, as well mechanisms addiction, mood disorders, neuropsychiatric abnormalities. review aims elucidate differences catalytic structure function seven sirtuins they relate psychiatry.

Language: Английский

Citations

1