Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721

Published: Aug. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

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Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Stroke is the leading cause of acquired disability. The development acute ischemic stroke treatments, such as mechanical thrombectomy and tissue plasminogen activator, has resulted in more patients surviving initial insult. However, long‐term complications, post‐stroke cognitive impairment (PSCI) dementia (PSD), are at an all‐time high. Notably, 80% survivors suffer from impairment, a history doubles patient's lifetime risk developing dementia. A combination greater life expectancy, increase number strokes young individuals, improved survival have inherently increased years living post‐stroke, highlighting critical need to understand effects stroke, including how pathological changes brain might give rise functional behavioral survivors. Even with this PSCI PSD survivors, understanding itself develops into these conditions remains incomplete. Recently, secondary neurodegeneration (SND) following been linked PSD. SND degeneration regions outside original site. Degeneration sites thought arise due diaschisis infarct core; however, observation pathology multiple without direct connectivity suggests that likely complex. Moreover, hallmarks dementia, deposition neurodegenerative proteins iron, cell death, inflammation blood–brain barrier alterations, all found thalamus, hippocampus, basal ganglia, amygdala prefrontal cortex stroke. Hence, review, we present current context outline remote anatomical molecular may drive conditions.

Language: Английский

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Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105726 - 105726

Published: May 16, 2024

Repetitive transcranial magnetic stimulation (rTMS) emerged as a non-invasive brain technique in the treatment of psychiatric disorders. Both preclinical and clinical studies well systematic reviews provide heterogeneous picture, particularly concerning protocols used rTMS. Here, we present review rTMS effects rodent models depressive-like symptoms with aim to identify most relevant factors that lead an increased therapeutic success. The influence different factors, such parameters (stimulus frequency intensity, duration stimulation, shape positioning coil), symptom severity individual characteristics (age, species genetic background rodents), on success are discussed. Accumulating evidence indicates ameliorates multitude models, effectively at high frequencies (≥5 Hz) especially adult rodents pronounced pathological phenotype. might be future by considering these using more standardized protocols.

Language: Английский

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A translational and multidisciplinary approach to studying the Garcia effect, a higher form of learning with deep evolutionary roots

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(8)

Published: April 15, 2024

Animals, including humans, learn and remember to avoid a novel food when its ingestion is followed, hours later, by sickness - phenomenon initially identified during World War II as potential means of pest control. In the 1960s, John Garcia (for whom effect now named) demonstrated that this form conditioned taste aversion had broader implications, showing it rapid but long-lasting taste-specific with fundamental role in evolution behaviour. From mid-1970s onward, principles were translated different clinical conditions (e.g. side-effects linked chemotherapy). However, last two decades, number studies on has undergone considerable decline. Since discovery rodents, learning was thought be exclusive mammals; however, we recently provided first demonstration can formed an invertebrate model organism, pond snail Lymnaea stagnalis. Thus, Commentary, after reviewing experiments led characterization describe recent evidence for L. stagnalis, which may pave way future other invertebrates mammals. This article aims inspire translational ecological characterize conserved mechanisms underlying deep evolutionary roots, used address range biological questions.

Language: Английский

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Lockbox enrichment facilitates manipulative and cognitive activities for mice

Open Research Europe, Journal Year: 2024, Volume and Issue: 4, P. 108 - 108

Published: June 4, 2024

Background Due to the lack of complexity and variety stimuli, conventional housing conditions laboratory mice do not allow these animals fully express their behavioral repertoire, including manipulative cognitive activities. Therefore, we designed mechanical puzzles, so-called lockboxes, for that can be provided in home cages. We investigated impact lockbox enrichment on phenotype affective state when compared super-environmental enrichment. Methods Young adult female C57BL/6JCrl were examined before after 2-month exposure different types a phenotyping test battery, tests trait anxiety-related behavior, calorimetric measurements, body weight analysis stress hormone metabolite concentrations as well sequential problem-solving abilities. At end study, adrenal gland weights determined pathohistological evaluation was performed. For all continuous variables, relative variability calculated. Results demonstrated decreased behavior Grid Exploratory Paradigm. In contrast, neither influenced Open Field Elevated Plus Maze Test nor physiological variables (i.e., bodyweight, resting metabolic rate, concentrations, weights). Lockbox improved Regardless condition, increased most over time, although coefficient variation some especially with access A revealed no evidence toxicopathological effects associated material from which made. Conclusions Overall, beneficial abilities mice. The reproducibility compromised by enrichment, similar enrichment.

Language: Английский

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A bespoke water T–maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 10, 2024

The Morris Water Maze (MWM) is the most commonly used assay for evaluating learning and memory in laboratory mice. Despite its widespread use, contemporary reviews have highlighted substantial methodological variation experimental protocols that associated testing procedures are acutely (each trial) chronically (testing across days) stressful; stress impairs attention, consolidation retrieval of learned information. Moreover, interpretation behavior within MWM often difficult because wall hugging, non-spatial swim strategies, floating, jumping off escape platform. Together, these issues may compromise reproducibility, generalizability, predictability results, as well animal welfare. To address issues, an initial proof-of-principle, we first narrowed spatial dimensions by using a T-insert, which constrained reduced overall length time/distance must order to navigate platform, thus reducing off-task behavior. Given robust performance observed acquisition (learning memory) during reversal (executive function), further (by 43%) distance time find platform bespoke standalone T-Maze (WTM). We show, five experiments, procedural refinements our protocol demonstrate robust, reliable reproducible indicators learning, executive functioning task also significantly more efficient (3 days WTM vs. 11 MWM). Taken together, apparatus significant improvement over other water-based apparatuses memory,

Language: Английский

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Lockbox enrichment facilitates manipulative and cognitive activities for mice

Open Research Europe, Journal Year: 2024, Volume and Issue: 4, P. 108 - 108

Published: Aug. 28, 2024

Background Due to the lack of complexity and variety stimuli, conventional housing conditions laboratory mice do not allow these animals fully express their behavioral repertoire, including manipulative cognitive activities. Therefore, we designed mechanical puzzles, so-called lockboxes, for that can be provided in home cages. We investigated impact lockbox enrichment on phenotype affective state when compared (CH) super-environmental (SEE). Methods Young adult female C57BL/6JCrl were examined before after 2-month exposure different types a phenotyping test battery, tests trait anxiety-related behavior, calorimetric measurements, body weight analysis stress hormone metabolite concentrations, sequential problem-solving abilities with novel lockbox. At end study, adrenal gland weights determined pathohistological evaluation was performed. For all continuous variables, relative variability calculated. Results While affected neither behavior nor physiological variables (i.e., bodyweight, resting metabolic rate, weights) influenced. LE improved solving lockboxes) SEE. Regardless condition, increased most over time, although coefficient variation decreased some especially access LE. There no evidence toxicopathological effects associated material from which lockboxes made. Conclusions All are available as open-source tool. revealed beneficial performance lockboxes. Neither relevant reproducibility data compromised by LE, similar The may also used approach assessing cognition mice.

Language: Английский

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Extracting Principles of Exploration Strategies with a Complex Ecological Task

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 289 - 300

Published: Sept. 6, 2024

Language: Английский

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Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol that probes learning rate, retention and cognitive flexibility.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

ABSTRACT Land-based mazes that require spatial cues to identify the location of a hiding-place are low-stress method evaluate learning rate and memory retention in mice. One version, Barnes maze, allows quantification naturalistic exploratory behaviors not evident water-based tasks. As task relies on innate behaviors, it does overtraining, making more feasible examine early non-memory executive functions characteristic some non-amnestic dementias. However, because is difficult hide odor traditional version during individual trials can be interpret. We designed tested use 3D-printed escape shuttles made duplicate, as well docking tunnel mice self-exit maze improve reproducibility limit experimenter influence. In combination with turning caps, we show our mitigate possibility undesired cues. then compare 4-day protocol across several mouse models cognitive impairment. demonstrate an additional stage, STARR (Spatial Training Rapid Reversal), better challenge such working behavioral flexibility. commonly used outcome measures without access cues, impairment protocol. Overall, this provides detailed instructions build perform robust help expand range deficits identified. Our findings will aid interpretation protocols, provide updated screen for both amnestic changes.

Language: Английский

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Mechanism of exacerbation of traumatic brain injury under warfarin anticoagulation in male mice

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0314765 - e0314765

Published: Dec. 5, 2024

Introduction Traumatic brain injury (TBI) is exacerbated in patients on antithrombotic medications, with warfarin leading to increased bleeding some cases. However, the extent which this increases lethality and its long-term effects remain unclear. This study aimed investigate exacerbation of TBI by treatment comprehensively evaluate impact anticoagulant warfarin. Methods We induced mice after pre-treatment analyzed based prothrombin time-international normalized ratio (PT-INR) value, hemorrhage volume, blood 7-hydroxywarfarin levels, cytochrome P450 2C9 (CYP2C9) protein expression. C57BL/6J fed a vitamin K-deficient diet received oral (low dose, 0.35 mg/kg/24 h; high 0.70 h), focal damage was cerebral cortices using contusion device. Warfarin-treated injured were compared sham-treated (scalp incision alone or scalp + bone window formation). Results When administered, PT-INR value volume associated first day post-injury. High levels observed. no significant differences CYP2C9 expression observed between groups. Discussion Elevated post-injury can increase risk, possibly worsening TBI. might also elevate heightening effects. Therefore, assessing severity values crucial anticipate delayed risks.

Language: Английский

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