Brain Research Bulletin,
Journal Year:
2024,
Volume and Issue:
217, P. 111060 - 111060
Published: Sept. 3, 2024
The
molecular
biology
mechanisms
underlying
postoperative
cognitive
dysfunction
(POCD)
remain
unclear,
resulting
in
a
lack
of
specific
therapeutic
targets
and
limited
clinical
treatment
options.
NLRP3
pyroptotic
pathway,
induced
by
neuroinflammation,
is
known
to
promote
the
development
POCD.
Research
has
shown
that
lncRNA
MEG3
exacerbates
cell
pyroptosis
various
neurological
injuries,
though
precise
mechanism
remains
be
investigated.
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: April 10, 2023
The
blood-brain
barrier
(BBB)
is
an
important
separating
the
central
nervous
system
from
periphery.
composition
includes
endothelial
cells,
pericytes,
astrocytes,
synapses
and
tight
junction
proteins.
During
perioperative
period,
anesthesia
surgical
operations
are
also
a
kind
of
stress
to
body,
which
may
be
accompanied
by
damage
brain
metabolism
dysfunction.
Perioperative
destruction
closely
associated
with
cognitive
impairment
increase
risk
postoperative
mortality,
not
conducive
enhanced
recovery
after
surgery.
However,
potential
pathophysiological
process
specific
mechanism
during
period
have
been
fully
elucidated.
Changes
in
permeability,
inflammation
neuroinflammation,
oxidative
stress,
ferroptosis,
intestinal
dysbiosis
involved
damage.
We
aim
review
research
progress
its
adverse
effects
molecular
mechanisms,
provide
ideas
for
study
homeostasis
maintenance
function
precision
anesthesia.
International Journal of Ophthalmology,
Journal Year:
2025,
Volume and Issue:
18(2), P. 199 - 208
Published: Jan. 16, 2025
AIM:
To
explore
the
effect
of
co-host
non-coding
RNA
(ncRNA)
MIR503HG/miR-503-5p
on
angiogenesis
pterygium.
METHODS:
MIR503HG/miR-503-5p/fibroblast
growth
factor
2
(FGF2)
expression
levels
in
pterygium
tissues,
control
conjunctival
and
human
fibroblasts
(HPF)
were
examined
by
reverse
transcription-polymerase
chain
reaction
(qRT-PCR)
immunohistochemical
methods.
Effects
low
molecular
weight
FGF2
(LWM
FGF2),
migration
retinal
microvascular
endothelial
cells
(HRMEC)
determined
an
HPF
HRMEC
co-culture
model
using
Western
blots,
wound
healing
assay,
Matrigel-based
tube
formation
Transwell
assay.
RESULTS:
MIR503HG/miR-503-5p/FGF2
pathway
was
actively
increased
tissue
there
a
negative
correlation
between
two
ncRNAs.
level
positively
correlated
with
MIR503HG
negatively
miR-503-5p.
Overexpressed
did
not
affect
HRMECs
cultured
separately,
but
significantly
affected
models.
blotting
revealed
that
overexpression
LMW
HPF.
CONCLUSION:
inhibits
angiogenic
function
interfering
interaction
via
reducing
Neuropsychiatric Disease and Treatment,
Journal Year:
2025,
Volume and Issue:
Volume 21, P. 259 - 269
Published: Feb. 1, 2025
Background:
POCD
is
a
common
postoperative
complication
associated
with
anesthesia
and
surgery.
Its
occurrence
reduces
the
quality
of
life
after
surgery
increases
risk
death
disability.
Related
studies
demonstrated
that
hyperlipidemia
could
affect
development
patients'
cognitive
dysfunction.
However,
association
between
has
not
been
well
examined.
Methods:
A
total
98
patients
were
divided
into
group
normal
lipid
based
on
blood
level.
Minimum
Mental
State
Examination
was
used
to
evaluate
preoperative
status.
The
assessed
Montreal
Cognitive
Assessment
1
day
before
operation
7
days
operation.
Telephone
Interview
for
Status-Modified
applied
ability
3
months
We
analyzed
incidence
its
potential
factors
according
scores
each
scale
Results:
including
52
in
46
completed
all
follow-up.
occurred
27
surgery,
19
(36.54%)
8
(17.39%)
group.
One
month
23
experienced
POCD,
17
(32.69%)
6
(13.04%)
And
three
20
14
(26.92%)
Through
univariate
multivariate
regression
analysis,
we
found
age
cholesterol
level
significantly
POCD.
Conclusion:
Preoperative
laparoscopic
gynecologic
tumor
Age
hypercholesterolemia
considered
independent
development.
Keywords:
metabolism
disorders,
perioperative
management,
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: March 13, 2024
Abstract
Circular
RNAs
(circRNAs)
have
garnered
significant
attention
in
the
field
of
neurodegenerative
diseases
including
Alzheimer’s
due
to
their
covalently
closed
loop
structure.
However,
involvement
circRNAs
postoperative
cognitive
dysfunction
(POCD)
is
still
largely
unexplored.
To
identify
genes
differentially
expressed
between
non-POCD
(NPOCD)
and
POCD
mice,
we
conducted
whole
transcriptome
sequencing
initially
this
study.
According
expression
profiles,
observed
that
circAKT3
was
associated
with
hippocampal
neuronal
apoptosis
mice.
Moreover,
found
overexpression
reduced
neurons
alleviated
POCD.
Subsequently,
through
bioinformatics
analysis,
our
data
showed
vitro
vivo
elevated
abundance
miR-106a-5p
significantly,
resulting
a
decrease
HDAC4
protein
an
increase
MEF2C
protein.
Additionally,
effect
blocked
by
inhibitor.
Interestingly,
could
activate
transcription
promoter
form
positive
feedback
loop.
Therefore,
findings
revealed
more
potential
modulation
ways
circRNA-miRNA
miRNA-mRNA,
providing
different
directions
targets
for
preclinical
studies
Ibrain,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 14, 2023
Abstract
Cardiopulmonary
bypass
(CPB)
is
often
used
in
cardiothoracic
surgery
because
its
nonphysiological
state
causes
pathophysiological
changes
the
body,
causing
multiorgan
and
multitissue
damage
to
varying
degrees.
Postoperative
cognitive
dysfunction
(POCD)
a
common
central
nervous
system
complication
after
cardiac
surgery.
The
etiology
mechanism
of
POCD
are
not
clear.
Neuroinflammation,
brain
mitochondrial
dysfunction,
cerebral
embolism,
ischemia,
hypoxia,
other
factors
related
pathogenesis
POCD.
There
close
relationship
between
CPB
POCD,
as
can
cause
inflammation,
hypoxia
reperfusion
injury,
microemboli
formation,
all
which
trigger
increases
medical
costs,
seriously
affects
patients'
quality
life,
mortality.
Currently,
there
lack
effective
treatment
methods
for
Commonly
include
preoperative
health
management,
reducing
inflammation
response
during
surgery,
preventing
implementing
individualized
rehabilitation
programs
Strengthening
preventive
measures
minimize
occurrence
adverse
effects.
Biology,
Journal Year:
2023,
Volume and Issue:
12(4), P. 567 - 567
Published: April 7, 2023
Accelerated
neurocognitive
decline
after
general
anesthesia/surgery,
also
known
as
perioperative
disorder
(PND),
is
a
widely
recognized
public
health
problem
that
may
affect
millions
of
patients
each
year.
Advanced
age,
with
its
increasing
prevalence
heightened
stress,
inflammation,
and
neurodegenerative
alterations,
consistent
contributing
factor
to
the
development
PND.
Although
strong
homeostatic
reserve
in
young
adults
makes
them
more
resilient
PND,
animal
data
suggest
pathophysiological
conditions
characterized
by
excessive
stress
inflammation
be
vulnerable
this
altered
phenotype
passed
future
offspring
(intergenerational
PND).
The
purpose
narrative
review
literature
authors’
own
experimental
findings
rodents
draw
attention
possibility
intergenerational
new
phenomenon
which,
if
confirmed
humans,
unravel
big
population
affected
parental
In
particular,
we
discuss
roles
epigenetic
alterations
We
demonstrate
effects
surgery,
traumatic
brain
injury,
anesthetic
sevoflurane
interact
induce
persistent
dysregulation
response
system,
markers,
behavior
adult
male
rats
their
who
have
neither
trauma
nor
exposure
(i.e.,
an
model
Anesthesiology and Perioperative Science,
Journal Year:
2024,
Volume and Issue:
2(4)
Published: Oct. 30, 2024
Abstract
Postoperative
cognitive
dysfunction,
a
common
neurological
complication
in
the
perioperative
period,
seriously
affects
patient
survival
and
prognosis.
Its
high
incidence
has
made
study
of
postoperative
dysfunction
challenging.
Whether
clinical
application
dexmedetomidine,
potential
neuroprotective
drug,
can
reduce
is
controversial,
although
several
mechanisms
by
which
dexmedetomidine
improves
have
been
identified;
therefore,
this
remains
an
area
need
further
exploration.
Acta Neurobiologiae Experimentalis,
Journal Year:
2023,
Volume and Issue:
unknown, P. 47 - 55
Published: Dec. 1, 2023
Sevoflurane
can
produce
toxicity
to
the
hippocampal
tissues
of
brain,
leading
nerve
damage,
causing
learning
and
cognitive
dysfunction.
CircRNAs
have
been
indicated
act
as
a
key
mediator
in
anesthetic
neurotoxicity.
This
study
focused
on
effect
circ_0016760
sevoflurane‑induced
neurological
impairment.
The
GEO
database
(GSE147277)
RT‑qPCR
were
used
predict
measure
expression.
interaction
miR‑145
was
verified
by
dual‑luciferase
reporter
assay.
CCK‑8
assay,
flow
cytometry,
ELISA,
ROS
kit,
MWM
test
carried
out
cell
viability,
apoptosis,
inflammation
indicators,
level,
memory
function
rats.
exacerbated
neurotoxicity
restraining
inducing
neuroinflammation,
generation,
Circ_0016760
expression
increased
POCD
patients
from
upregulated
after
sevoflurane
exposure.
target
miRNA
circ_0016760.
Silencing
weakened
inflammation‑related
factors,
oxidative
stress,
which
could
be
reversed
inhibitor.
animal
experiments
results
showed
that
played
protective
regulating
behavior
sevoflurane‑treated
aged
rats,
cytokine,
stress
factors
through
targeting
rat’s
neurons.
Our
revealed
silencing
attenuated
neuron
injury
expression,
may
provide
potential
insights
into
treatment
