Absence of Modulatory Effects of Cerebellar Transcranial Alternating Current Stimulation in the Theta Band on Fear Learning in Men DOI

Sarah Johanna Schellen,

Philip Zeidan,

Thomas Ernst

et al.

Published: Jan. 1, 2023

Fear is a vital defense mechanism to potential threats, which influenced by the cerebellum. While cerebellum’s role in acquiring fear responses well understood, limited knowledge exists about its involvement extinction. In this study, we investigated effects of cerebellar theta band transcranial alternating current stimulation (ctACS) administered during extinction training, based on previous evidence from animal studies suggesting oscillations associative memory formation. To end, thirty-seven healthy right-handed male participants were recruited for two-day differential renewal paradigm. On day 1, they underwent acquisition training context A followed B. 2, recall was tested contexts and One group received ctACS (6 Hz) training. The other sham ctACS. Although both groups demonstrated ability previously learned distinguish between low high threat stimuli, no significant differences observed groups, indicating that at frequency range did not impact acquired study. Nevertheless, using could still be useful future research, including brain imaging studies, better understand how cerebellum involved processes.

Language: Английский

Cerebellar nuclei neurons projecting to the lateral parabrachial nucleus modulate classical fear conditioning DOI Creative Commons
Kyoung‐Doo Hwang, Jinhee Baek, Hyun-Hee Ryu

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(4), P. 112291 - 112291

Published: March 22, 2023

Multiple brain regions are engaged in classical fear conditioning. Despite evidence for cerebellar involvement conditioning, the mechanisms by which outputs modulate learning and memory remain unclear. We identify a population of deep nucleus (DCN) neurons with monosynaptic glutamatergic projections to lateral parabrachial (lPBN) (DCN→lPBN neurons) mice. While optogenetic suppression DCN→lPBN impairs auditory memory, activation elicits freezing behavior only after Moreover, conditioning potentiates DCN-lPBN synapses, subsequently, cue activates lPBN Furthermore, neuron can replace but not footshock These findings demonstrate that nuclei via transmitting conditioned stimuli signals lPBN. Collectively, our suggest circuit is part neuronal substrates within interconnected underscoring memory.

Language: Английский

Citations

17
Partial restoration of brain dystrophin by tricyclo-DNA antisense oligonucleotides alleviates emotional deficits in mdx52 mice DOI Creative Commons

Amel Saoudi,

Sacha Barberat,

Olivier Le Coz

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2023, Volume and Issue: 32, P. 173 - 188

Published: March 21, 2023

The mdx52 mouse model recapitulates a frequent mutation profile associated with brain involvement in Duchenne muscular dystrophy. Deletion of exon 52 impedes expression two dystrophins (Dp427, Dp140) expressed brain, and is eligible for therapeutic exon-skipping strategies. We previously showed that mice display enhanced anxiety fearfulness, impaired associative fear learning. In this study, we examined the reversibility these phenotypes using 51 skipping to restore exclusively Dp427 mice. first show single intracerebroventricular administration tricyclo-DNA antisense oligonucleotides targeting restores 5%–15% dystrophin protein hippocampus, cerebellum, cortex, at stable levels between 7 11 week after injection. Anxiety unconditioned were significantly reduced treated acquisition conditioning appeared fully rescued, while memory tested 24 h later was only partially improved. Additional restoration skeletal cardiac muscles by systemic treatment did not further improve response, confirming central origin phenotype. These findings indicate some emotional cognitive deficits deficiency may be reversible or least improved partial postnatal rescue.

Language: Английский

Citations

12
Anatomy, histology, physiology, and connectivity of the cerebellum DOI

Jos J. Eggermont

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dual and plasticity-dependent regulation of cerebello-zona incerta circuits on anxiety-like behaviors DOI Creative Commons

Yue Zhao,

Jintao Wu, Jiabin Feng

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 8, 2025

Clinical observation has identified cerebellar cognitive affective syndrome, which is characterized by various non-motor dysfunctions such as social disorders and anxiety. Increasing evidence revealed reciprocal mono-/poly-synaptic connections of cerebello-cerebral circuits, forming the concept connectome. In this study, we demonstrate that neurons in nuclei (CN) male mice project to a subset zona incerta (ZI) through long-range glutamatergic GABAergic transmissions, both capable encoding acute stress. Furthermore, activating or inhibiting transmissions CN → ZI pathway can positively negatively regulate anxiety place preference presynaptic plasticity-dependent mechanisms, well mediate motor-induced alleviation Our data support close relationship between cerebellum emotional processes suggest targeting outputs may be an effective approach for treating

Language: Английский

Citations

0
Region- and cell type-specific changes in gene expression in the cerebellum after classical fear conditioning DOI
Yong‐Seok Lee,

Jungeun Ji,

Jinhee Baek

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract The cerebellum has recently been recognized for its role in non-motor functions, including classical fear conditioning. However, the molecular mechanisms underlying learning and memory remain largely unknown. Here, we investigate transcriptional changes associated with auditory Spatial transcriptomic analysis revealed that deep cerebellar nuclei (DCN), an output region of cerebellum, expression immediate early genes increased following retrieval, suggesting DCN may contribute to processing. As cortex, robust region-specific were observed, distinct patterns emerging across Purkinje cell layer vermis region. To further elucidate specific types involved processing, performed single-nucleus RNA sequencing identified prominent gene Kit + inhibitory neurons. Collectively, our findings highlight region- cell-type-specific adaptations providing insights into contribution learning.

Language: Английский

Citations

0
Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory DOI
Jaegeon Lee, Seung Ha Kim, Dong Cheol Jang

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(2), P. 247 - 256

Published: Nov. 28, 2023

Language: Английский

Citations

5
RCPL preprint: An externally validated resting-state brain connectivity signature of pain-related learning DOI Open Access
Bálint Kincses, Katarina Forkmann, Frederik Schlitt

et al.

Published: Oct. 6, 2023

Pain can be conceptualized as a precision signal for reinforcement learning in the brain and alterations these processes are hallmark of chronic pain conditions. Investigating individual differences pain-related therefore holds significant clinical translational relevance.Here, we developed externally validated novel resting-state connectivity-based predictive model learning. The pre-registered external validation indicated that proposed is specific pain, explains 8-12% inter-individual variance performance. Model redictions driven by connections amygdala, posterior insula, sensorimotor, frontoparietal cerebellar regions, outlining network commonlydescribed aversive pain. We propose resulting robust highly accessible biomarker candidate research, with promising implications personalized treatment approaches high potential to advance our understanding neural mechanisms

Language: Английский

Citations

4
Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome DOI Creative Commons
Amin Md Shakhawat,

Jacqueline G Foltz,

Adam B. Nance

et al.

eLife, Journal Year: 2024, Volume and Issue: 12

Published: July 2, 2024

The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments can result from saturation the mechanism (Nguyen-Vu et al., 2017), or, more generally, a history-dependent change threshold for plasticity. This hypothesis was based on experimental mice lacking two class I major histocompatibility molecules, MHCI H2-K b and H2-D (MHCI K D b−/− ), which have long-term depression at parallel fiber-Purkinje cell synapses cerebellum (PF-Purkinje LTD). Here, extend this work by testing predictions metaplasticity second mouse line with PF-Purkinje LTD, Fmr1 knockout model Fragile X syndrome (FXS). Mice gene expression cerebellar Purkinje cells (L7- KO) were selectively oculomotor tasks LTD has been implicated, no impairment LTD-independent tasks. Consistent hypothesis, behavioral pre-training designed to reverse eliminated deficit L7- KO mice, as previously reported mice. In addition, diazepam treatment suppress neural activity thereby limit induction during period also deficits These support LTD-dependent is governed an experience-dependent sliding An increased response elevated would tend oppose firing rate stability, but could serve stabilize weights recently acquired memories. perspective inform development new clinical approaches addressing autism other disorders nervous system.

Language: Английский

Citations

1
A cognitive computing approach for product configuration design based on associative rule mining and deep reinforcement learning DOI
Xuanyu Wu,

Yixiong Feng,

Shanhe Lou

et al.

International Journal of Production Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: Nov. 21, 2024

Language: Английский

Citations

1
The sexually divergent cFos activation map of fear extinction DOI Creative Commons
Kai Zhang, Dan Shen, Shihao Huang

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23748 - e23748

Published: Dec. 19, 2023

Post-traumatic stress disorder (PTSD) is a neuropsychiatric that can develop after experiencing or witnessing traumatic event. Exposure therapy common treatment for PTSD, but it has varying levels of efficacy depending on sex. In this study, we aimed to compare the sexual dimorphism in brain activation during extinction fear conditioning male and female rats by detecting c-fos whole brain.

Language: Английский

Citations

3