Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 29, 2023
Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with posting preprint. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.
Language: Английский
Stem Cell Reviews and Reports, Journal Year: 2023, Volume and Issue: 19(5), P. 1214 - 1231
Published: April 14, 2023
Abstract Mesenchymal stem cells (MSCs) are regarded as highly promising for allogeneic cell therapy, owing to their multipotent nature and ability display potent varied functions in different diseases. The of MSCs, including native immunomodulation, high self-renewal characteristic, secretory trophic properties, can be employed improve the immune-modulatory MSCs impact most immune by directly contacting and/or secreting positive microenvironmental factors influence them. Previous studies have reported that immunomodulatory role is basically dependent on secretion from MSCs. This review discusses capabilities strategies successfully potential utilization clinical research. Graphical
Language: Английский
Citations
45
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 5, 2025
Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.
Language: Английский
Citations
1
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1643 - 1658
Published: March 1, 2024
Background: Intracerebral hemorrhage (ICH), a devastating form of stroke, is characterized by elevated morbidity and mortality rates. Neuroinflammation common occurrence following ICH. Mesenchymal stem cells (MSCs) have exhibited potential in treating brain diseases due to their anti-inflammatory properties. However, the therapeutic efficacy MSCs limited intense inflammatory response at transplantation site Hence, enhancing function transplanted holds considerable promise as strategy for Notably, iron-quercetin complex (IronQ), metal-quercetin synthesized through coordination chemistry, has garnered significant attention its biomedical applications. In our previous studies, we observed that IronQ exerts stimulatory effects on cell growth, notably survival viability peripheral blood mononuclear (PBMCs) MSCs. This study aimed evaluate pretreated with neuroinflammation elucidate underlying mechanisms. Methods: The ICH mice were induced injecting collagenase I solution into right caudate nucleus. After 24 hours, randomly divided four subgroups, model group (Model), quercetin (Quercetin), (MSCs), (MSCs+IronQ). Neurological deficits re-evaluated day 3, samples collected further analysis. TUNEL staining was performed assess DNA damage, protein expression levels factors cGAS-STING signaling pathway investigated analyzed. Results: Pretreated effectively mitigate neurological reduce neuronal inflammation modulating microglial polarization. Moreover, suppress pathway. Conclusion: These findings suggest demonstrate synergistic effect alleviating neuroinflammation, thereby improving function, which achieved inhibition Keywords: mesenchymal cells, IronQ, intracerebral hemorrhage, cGAS/STING/NFκB,
Language: Английский
Citations
5
Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(3), P. 827 - 872
Published: June 24, 2024
In the recent past, formulation and development of nanocarriers has been elaborated into broader fields opened various avenues in their preclinical clinical applications. particular, cellular membrane-based nanoformulations have formulated to surpass surmount limitations restrictions associated with naïve or free forms therapeutic compounds circumvent physicochemical immunological barriers including but not limited systemic barriers, microenvironmental roadblocks, other subcellular hinderances-which are quite heterogeneous throughout diseases patient cohorts. These drug delivery overcome through mesenchymal cells precision therapeutics, where these interventions led significant enhancements efficacies. However, still focuses on optimization paradigms a one-size-fits-all resolutions. As stem cell engineered highly diversified fashions, being optimized for delivering payloads more better personalized modes, entering arena as well nanomedicine. this Review, we included some advanced which designed utilized both non-personalized applicability can be employed improvements nanotherapeutics. present report, authors focused aspects advancements nanoparticle conceptions several roadblocks It suggested that well-informed designing will lead appreciable efficacy payload approaches also enable tailored customized designs MSC-based applications, finally amending outcomes.
Language: Английский
Citations
5
Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15
Published: Oct. 11, 2022
Microglia are the resident immune cells of central nervous system (CNS) and play a key role in neurological diseases, including intracerebral hemorrhage (ICH). activated to acquire either pro-inflammatory or anti-inflammatory phenotypes. After onset ICH, mediators produced by microglia at early stages serve as crucial character neuroinflammation. Conversely, switching microglial shift an phenotype could alleviate inflammatory response incite recovery. This review will elucidate dynamic profiles phenotypes their available following ICH. study can facilitate understanding self-regulatory functions involving Moreover, suggestions for future preclinical clinical research potential intervention strategies discussed.
Language: Английский
Citations
21
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Aug. 13, 2024
Hemorrhagic stroke is a devastating cerebrovascular event with high rate of early mortality and long-term disability. The therapeutic potential mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) for neurological conditions, such as intracerebral hemorrhage (ICH), has garnered considerable interest, though their mechanisms action remain poorly understood.
Language: Английский
Citations
4
Neuroscience, Journal Year: 2023, Volume and Issue: 537, P. 93 - 104
Published: Dec. 5, 2023
Language: Английский
Citations
10
Brain Hemorrhages, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 6, 2024
The vasculature system is composed of a multiplicity juxtaposed cells to generate functional biological barrier between the blood and tissues. On luminal surface vessels, endothelial (ECs) are in close contact with circulating while supporting basal lamina pericytes wrap abluminal surface. Thus, reciprocal interaction ECs vital element physiological activity vascular system. Several reports have indicated that occurrence pericyte dysfunction under ischemic degenerative conditions results varied micro macro-vascular complications. Emerging evidence points fact autophagy, conserved self-digestive cell machinery, can regulate several like response various stresses pathological conditions. Here, we aim highlight role autophagic angiogenesis potential following different
Language: Английский
Citations
3
Translational Stroke Research, Journal Year: 2024, Volume and Issue: unknown
Published: April 1, 2024
Abstract Intracerebral hemorrhage (ICH) is the most serious form of stroke and has limited available therapeutic options. As knowledge on ICH rapidly develops, cutting-edge techniques in fields surgical robots, regenerative medicine, neurorehabilitation may revolutionize treatment. However, these new advances still must be translated into clinical practice. In this review, we examined several emerging strategies their major challenges managing ICH, with a particular focus innovative therapies involving robot-assisted minimally invasive surgery, stem cell transplantation, situ neuronal reprogramming, brain-computer interfaces. Despite expansion drug armamentarium for over past few decades, judicious selection more efficacious modalities exploration multimodal combination represent opportunities to improve patient prognoses after ICH.
Language: Английский
Citations
3