Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3159 - 3159
Published: March 9, 2024
The
present
investigation
was
designed
based
on
the
evidence
that,
in
neurodegenerative
disorders,
such
as
Alzheimer’s
dementia
(AD)
and
Parkinson’s
disease
(PD),
damage
to
locus
coeruleus
(LC)
arising
norepinephrine
(NE)
axons
(LC-NE)
is
documented
hypothesized
foster
onset
progression
of
neurodegeneration
within
target
regions.
Specifically,
experiments
were
assess
whether
selective
LC-NE
may
alter
key
proteins
involved
specific
limbic
regions,
hippocampus
piriform
cortex,
compared
with
dorsal
striatum.
To
achieve
this,
a
loss
induced
by
neurotoxin
N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine
(DSP4)
C57
Black
mice,
assessed
NE
dopamine-beta-hydroxylase
In
these
experimental
conditions,
amount
alpha-synuclein
(alpha-syn)
protein
levels
increased
along
alpha-syn
expressing
neurons
cortex.
Similar
findings
obtained
concerning
phospho-Tau
immunoblotting.
contrast,
decrease
inducible
HSP70-expressing
sequestosome
(p62)-expressing
cells,
at
immunoblotting,
reported.
data
provide
further
understand
why
AD
engagement
during
PD.
Language: Английский
The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI
Frontiers in Cellular Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Dec. 11, 2024
The
locus
coeruleus
(LC)
produces
most
of
the
brain's
noradrenaline
(NA).
Among
its
many
roles,
NA
is
often
said
to
be
neuroprotective
and
important
for
brain
upkeep.
For
this
reason,
loss
LC
integrity
thought
impact
volume
microstructure
as
well
plasticity
broadly.
dysfunction
also
a
suspected
driver
in
development
neurodegenerative
diseases.
Nevertheless,
on
gross
structure
normal
brains
not
well-studied.
We
employed
high-field
ex
vivo
magnetic
resonance
imaging
(MRI)
investigate
volumetrics
control
(CON)
mice
with
ablation
(LCA)
at
two
ages,
representing
developing
fully
matured
brain.
These
whole-brain
methods
are
known
capable
detecting
subtle
morphological
changes
microstructural
remodeling.
found
behavior
consistent
histologically
confirmed
ablation.
However,
MRI
showed
no
difference
between
CON
LCA
groups
regard
size,
relative
regional
volumes,
or
indices.
Our
findings
suggest
that
LC-NA
needed
postnatal
maturation
growth
mice.
Nor
it
required
maintenance
adult
mouse
brain,
atrophy
aberration
detected
after
weeks
dysfunction.
This
adds
clarity
often-encountered
notion
"trophic
support"
shows
such
effects
likely
relevant
mechanisms
related
neuroprotection
(pre)diseased
Language: Английский