Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3160 - 3160
Published: March 9, 2024
The relationship between sleep, glial cells, and the endocannabinoid system represents a multifaceted regulatory network with profound implications for neuroinflammation cognitive function. molecular underpinnings of sleep modulation by its influence on cell activity are discussed, shedding light reciprocal relationships that govern these processes. Emphasis is placed understanding role cells in mediating neuroinflammatory responses their patterns. Additionally, this review examines how interfaces glia-immune signaling to regulate inflammatory cascades within central nervous system. Notably, consequences disrupted neuroinflammation, dysfunction addressed, encompassing neurodegenerative disorders, mood disturbances, decline. Insights into bidirectional function context explored, providing comprehensive perspective potential mechanisms underlying impairments associated disturbances. Furthermore, therapeutic avenues targeting mitigate restore homeostasis, normalize identification novel targets intricate holds promise addressing conditions characterized dysfunction. This work aims examine complexities neural regulation identify intervention.
Language: Английский
Citations
6
SLEEP, Journal Year: 2024, Volume and Issue: 47(10)
Published: June 26, 2024
Sleep deficiency is a rampant issue in modern society, serving as pathogenic element contributing to learning and memory impairment, with heightened sensitivity observed children. Clinical observations suggest that disabilities associated insufficient sleep during adolescence can persist through adulthood, but experimental evidence for this lacking. In study, we examined the impact of early-life deprivation (SD) on both short-term long-term memory, tracking effects sequentially into adulthood. We employed modified multiple-platform method mouse model investigate these outcomes. SD induced over 14-day period, beginning postnatal day 28 (PND28) mice, led significant impairment (while remained unaffected) at PND42. Notably, dysfunction persisted adulthood PND85. The specific was elucidated histopathological alterations hippocampal neurogenesis, evidenced by bromodeoxyuridine (BrdU) signals, PND42 Furthermore, region exhibited significantly diminished protein expressions astrocytes, characterized lowered levels aquaporin 4 (AQP4), representative molecule involved brain clearance processes, reduced brain-derived neurotrophic factors. conclusion, have presented indicating deficiency-related endure corresponding mechanisms may indicate modification astrocyte-related molecules has changes neurogenesis.
Language: Английский
Citations
6
Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 833 - 833
Published: July 12, 2024
Sleep deprivation (SD) triggers mitochondrial dysfunction and neural inflammation, leading to cognitive impairment mental issues. However, the mechanism involving inflammation still remains unclear. Here, we report that SD rats exhibited multiple behavioral disorders, brain oxidative stress, robust DNA (mtDNA) oxidation. In particular, activated microglia microglial mtDNA efflux cytosol provoked pro-inflammatory cytokines. We observed cytokines significantly reduced with suppression of With treatment a novel nutrient, hydroxytyrosol butyrate (HTHB), SD-induced disorders were ameliorated while oxidation, release, NF-κB activation remarkably alleviated in both rat N9 cell line. Together, these results indicate oxidation resultant release induced by mediate HTHB prevents efflux, providing potential for
Language: Английский
Citations
4
Sleep Medicine, Journal Year: 2025, Volume and Issue: 129, P. 316 - 329
Published: Feb. 25, 2025
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1691 - 1691
Published: March 15, 2024
Forensic hospitals throughout the country house individuals with severe mental illness and history of criminal violations. Insomnia affects 67.4% hospitalized patients chronic neuropsychiatric disorders, indicating that these conditions may hijack human somnogenic pathways. Conversely, somnolence is a common adverse effect many antipsychotic drugs, further highlighting etiopathogenesis. Since brain salience network likely denominator for insomnia, neurodegenerative here, we focus on pathology this neuronal assembly its driver, dysfunctional mitochondrial membrane. We also discuss potential treatment strategies ranging from membrane lipid replacement to transplantation. The aims review are threefold: 1. Examining causes insomnia in forensic detainees illness, as well role predisposing them disorders. 2. Educating State hospital prison clinicians frontotemporal dementia behavioral variant, condition increasingly diagnosed older first offenders which often missed due absence memory impairment. 3. Introducing natural compounds potentially beneficial illness.
Language: Английский
Citations
2
Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown, P. 77 - 96
Published: Jan. 1, 2024
Language: Английский
Citations
2
Ibrain, Journal Year: 2024, Volume and Issue: 10(2), P. 197 - 216
Published: June 1, 2024
Abstract This review comprehensively assesses the epidemiology, interaction, and impact on patient outcomes of perioperative sleep disorders (SD) neurocognitive (PND) in elderly. The incidence SD PND during period older adults is alarmingly high, with significantly contributing to occurrence postoperative delirium. However, clinical evidence linking remains insufficient, despite substantial preclinical data. Therefore, this study focuses underlying mechanisms between PND, underscoring that potential driving SD‐induced include uncontrolled central nervous inflammation, blood–brain barrier disruption, circadian rhythm disturbances, glial cell dysfunction, neuronal synaptic abnormalities, impaired metabolic waste clearance, gut microbiome dysbiosis, hippocampal oxidative stress, altered brain network connectivity. Additionally, also evaluates effectiveness various interventions, both pharmacological nonpharmacological, mitigating PND. Strategies such as earplugs, eye masks, restoring rhythms, physical exercise, noninvasive stimulation, dexmedetomidine, melatonin receptor agonists have shown efficacy reducing incidence. other sleep‐improvement drugs (e.g., orexin antagonists) methods cognitive‐behavioral therapy for insomnia) still unclear. certain used treating antidepressants first‐generation antihistamines) may potentially aggravate By providing valuable insights references, aimed enhance understanding management based SD.
Language: Английский
Citations
1
Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
Citations
0