2-(3,4-Dihydroxyphenyl)ethyl 3-hydroxybutanoate Ameliorates Cognitive Dysfunction and Inflammation Via Modulating Gut Microbiota in Aged Senescence-Accelerated Mouse Prone8 Mice DOI
Le Shi,

Peipei Gao,

Yue Zhang

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(12)

Published: Aug. 31, 2024

Abstract Numerous studies have indicated a close association between gut microbiota dysbiosis, inflammation, and cognitive impairment, highlighting their crucial role in the aging process. 2-(3,4-Dihydroxyphenyl)ethyl 3-hydroxybutanoate (HTHB), novel derivative of hydroxytyrosol, known for its metabolic anti-inflammatory properties, was investigated effects on memory, senescence-accelerated mouse prone 8 mice. The study employed behavioral testing, biochemical detection, 16S RNA analysis. Results revealed that HTHB mitigated memory decline lymphocyte aberrance, reduced inflammation brain cortex, intestine peripheral system, modulated dysbiosis. Interestingly, function serum mice significantly correlated with differences Furthermore, treatment exhibited an enhancement barrier integrity colon tissue SAMP8 In vitro experiments using HCT116 DLD1 cells further evidenced rescued tight junction protein levels impaired by lipopolysaccharide. These findings demonstrate effectively ameliorates dysfunction aged mice, modulating microbiota, suppressing promoting intestinal integrity. This highlights potential as therapeutic agent age-related loss.

Language: Английский

Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders DOI Creative Commons
Guangming Zhang,

Huayuan Wei,

Anliu Zhao

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 7, 2025

Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.

Language: Английский

Citations

3
Mitochondrial membrane chromatography: Discovery of mitochondrial targeting modulators DOI Creative Commons
Wu Su, Yu Kong, Hua Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101272 - 101272

Published: March 1, 2025

Language: Английский

Citations

0
Hydroxytyrosol as a Mitochondrial Homeostasis Regulator: Implications in Metabolic Syndrome and Related Diseases DOI Creative Commons
Jie Xu, Wei He, Zhenyu Sun

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 398 - 398

Published: March 27, 2025

Hydroxytyrosol (HT), a principal bioactive phytochemical abundant in Mediterranean dietary sources, has emerged as molecule of significant scientific interest owing to its multifaceted health-promoting properties. Accumulating evidence suggests that HT’s therapeutic potential metabolic disorders extends beyond conventional antioxidant capacity encompass mitochondrial regulatory networks. This review synthesizes contemporary from our systematic investigations and the existing literature delineate comprehensive modulatory effects on homeostasis. We systematically summarized impact HT dynamics (fusion/fission equilibrium), biogenesis energy metabolism, mitophagy, inter-organellar communication with endoplasmic reticulum, microbiota–mitochondria crosstalk. Through this multidimensional analysis, we established homeostasis modulator applications syndrome (MetS) related pathologies including type 2 diabetes mellitus, obesity-related dysfunction, dyslipidemia, non-alcoholic steatohepatitis, hypertension-related complications. Moreover, further discussed translational challenges research, emphasizing imperative for direct target identification, mitochondrial-targeted delivery system development, combinatorial strategies. Collectively, provides mechanistic framework advancing research accelerating clinical implementation MetS diseases.

Language: Английский

Citations

0
2-(3,4-Dihydroxyphenyl)ethyl 3-hydroxybutanoate Ameliorates Cognitive Dysfunction and Inflammation Via Modulating Gut Microbiota in Aged Senescence-Accelerated Mouse Prone8 Mice DOI
Le Shi,

Peipei Gao,

Yue Zhang

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(12)

Published: Aug. 31, 2024

Abstract Numerous studies have indicated a close association between gut microbiota dysbiosis, inflammation, and cognitive impairment, highlighting their crucial role in the aging process. 2-(3,4-Dihydroxyphenyl)ethyl 3-hydroxybutanoate (HTHB), novel derivative of hydroxytyrosol, known for its metabolic anti-inflammatory properties, was investigated effects on memory, senescence-accelerated mouse prone 8 mice. The study employed behavioral testing, biochemical detection, 16S RNA analysis. Results revealed that HTHB mitigated memory decline lymphocyte aberrance, reduced inflammation brain cortex, intestine peripheral system, modulated dysbiosis. Interestingly, function serum mice significantly correlated with differences Furthermore, treatment exhibited an enhancement barrier integrity colon tissue SAMP8 In vitro experiments using HCT116 DLD1 cells further evidenced rescued tight junction protein levels impaired by lipopolysaccharide. These findings demonstrate effectively ameliorates dysfunction aged mice, modulating microbiota, suppressing promoting intestinal integrity. This highlights potential as therapeutic agent age-related loss.

Language: Английский

Citations

1