The diverse role of corticotropin-releasing factor (CRF) and its CRF1 and CRF2 receptors under pathophysiological conditions: Insights into stress/anxiety, depression, and brain injury processes

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105748 - 105748

Published: June 8, 2024

Language: Английский

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Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Psychopharmacotherapy is often used to treat anxiety- and stress-associated psychiatric disorders, including posttraumatic stress disorder (PTSD). Adjunctive therapy most typically with medications that influence serotonin balance, such as selective reuptake inhibitors (SSRIs). Contrary expectations, SSRIs show an anxiety-increasing effect during the initial treatment phase. Among 14 different receptor subtypes, pharmacological studies have demonstrated 5-HT2C receptors (5-HT2CRs) in bed nucleus of stria terminalis (BNST) play a significant role anxiogenic acute SSRI treatment. Although numerous confirmed 5-HT2CR anxiety behavior, little known about its involvement learned fear extinction. In particular, extinction considered central neural mechanism PTSD patients. Recent results from knockout mice (2CKO) revealed global loss 5-HT2CRs enhances extinction, without affecting acquisition. Here, we implemented chemogenetic approach examine neuronal substrate which underlies this extinction-enhancing 2CKO mice. DREADD-activation BNST^CRF neurons promotes WT mice, whereas DREADD-inactivation impairs Thus, using activating inactivating DREADDs, were able directionally modulate These findings provide possible explanation for relevance

Language: Английский

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The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 10, 2025

Fear can be induced either directly through self-experience of aversive events or vicariously by observing conspecifics experiencing such events. The locus coeruleus-norepinephrine (LC-NA) system is crucial in fear responses and cognitive processes. We investigated whether the LC-NA differentially processes these two types fear, direct vicarious male mice. results highlighted that right hemisphere LC→anterior cingulate cortex pathway uniquely for while inputs to LC—from bed nucleus stria terminalis (BNST) central amygdala (CeA)—differentially contribute processing. BNST plays a more targeted role CeA has broader influence on general. This underscores complexity specialization within fear-processing. arises vicariously, with involved both. Here, authors show LC → ACC key provide distinct LC, highlighting its complex fear.

Language: Английский

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Collateral projections from the lateral parabrachial nucleus to the bed nucleus of the stria terminalis and the central amygdala in mice

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138204 - 138204

Published: March 1, 2025

Language: Английский

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Changes in estrogen receptor α positive cells in the amygdala and bed nucleus of the stria terminalis during pregnancy and the postpartum period in rats

Histochemistry and Cell Biology, Journal Year: 2025, Volume and Issue: 163(1)

Published: April 30, 2025

Language: Английский

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Stress modulates BNST connectivity during food cue and taste processing: a 7T dynamic causal modelling study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Across species, stress drives alterations in feeding behaviour, including heightened food-seeking and the overconsumption of palatable foods. The bed nucleus stria terminalis (BNST) acts as a neural hub linking reward circuits. However, its role human food cue taste processing under remains unclear. Here, using 7-Tesla fMRI, dynamic causal modelling, in-scanner delivery, we demonstrate that beverage cues receipt modulate effective connectivity BNST stress. Forty-eight participants were presented neutral before receiving corresponding beverages low- high-stress conditions. We found inhibits to accumbens, orbitofrontal cortex, anterior insula. Moreover, high has an inhibitory influence on from insula BNST, strength which predicts participant sensitivity. These findings provide first evidence humans modulates connectivity, leading inhibition cortico-striatal circuitry.

Language: Английский

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Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes

Cell Reports, Journal Year: 2024, Volume and Issue: 43(7), P. 114489 - 114489

Published: July 1, 2024

It is well established that the basolateral amygdala (BLA) an emotional processing hub governs a diverse repertoire of behaviors. Selective engagement heterogeneous cell population in BLA thought to contribute this flexibility behavioral outcomes. However, whether process impacted by previous experiences influence remains unclear. Here we demonstrate positive (enriched environment [EE]) or negative (chronic unpredictable stress [CUS]) differentially activity populations principal neurons projecting either nucleus accumbens core bed stria terminalis. Chemogenetic manipulation these projection-specific can mimic occlude effects CUS and EE on outcomes bidirectionally control avoidance behaviors stress-induced helplessness. These data responsiveness neurons, biasing information routing through BLA, drive divergent

Language: Английский

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Brain RFamide Neuropeptides in Stress-Related Psychopathologies

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1097 - 1097

Published: June 25, 2024

The RFamide peptide family is a group of proteins that share common C-terminal arginine–phenylalanine–amide motif. To date, the comprises five groups in mammals: neuropeptide FF, LPXRFamides/RFamide-related peptides, prolactin releasing peptide, QRFP, and kisspeptins. Different peptides have their own cognate receptors are produced by different cell populations, although they all can also bind to FF with affinities. function brain as neuropeptides regulating key aspects homeostasis such energy balance, reproduction, cardiovascular function. Furthermore, involved organization stress response including modulation pain. Considering interaction between various parameters homeostasis, role may be critical development stress-related neuropathologies. This review will therefore focus on possible hubs psychopathologies. neurotransmitter coexpression profile RFamide-producing cells discussed, highlighting its potential functional significance. novel pharmaceutical agents for treatment disorders an ongoing need. Thus, importance research underlined emergence peptidergic G-protein coupled receptor-based therapeutic targets industry.

Language: Английский

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Frontiers and hotspots in anxiety disorders: A bibliometric analysis from 2004 to 2024

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35701 - e35701

Published: Aug. 1, 2024

This study aimed to analyze research on anxiety disorders using VOSviewer and CiteSpace identify hotspots future directions.

Language: Английский

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The regulative role and mechanism of BNST in anxiety disorder

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Anxiety disorders, common yet impactful emotional disturbances, significantly affect physical and mental health globally. Many neuron circuits are associated with anxiety regulation like septo-hippocampal loop, amygdala(AMYG), bed nucleus of the stria terminalis (BNST), ventral hippocampus (vHPC), brain regions medial prefrontal cortex (mPFC). However, concrete mechanism disorder in BNST is relatively unknown. Recent research showed plays a critical role modulating owing to its anatomical location special circuit characteristics, which considered be hub limbic system regulating anxiety. consists multiple subregions, can project separately into different exert projecting independently various distinct regulatory effects. Moreover, signal pathways reported play significant roles stress behavior. This review briefly describes disorders subdivisions functions BNST, focusing on main neural that serve as fundamental both genesis potential treatment molecular The complexity structures mechanisms has facilitated development imaging techniques. Innovative multimodal techniques, such functional magnetic resonance (fMRI) positron emission tomography (PET), have non-invasively illuminated activities their connections other areas. These methodologies provide deeper understanding how responds anxiety-inducing stimuli, offering invaluable insights complex regulation. continued exploration promises not only elucidate neurobiological but also foster advancements clinical treatments for disorders.

Language: Английский

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