Journal of Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 132, P. 110997 - 110997
Published: Dec. 26, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 636 - 636
Published: Jan. 14, 2025
Neuroinflammation is involved in various neurological and neurodegenerative disorders which the activation of microglia one key factors. In this study, we examined anti-inflammatory effects flavonoids nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) eriodictyol (3′,4′,5,7-tetraxydroxyflavanone) on human cell line stimulated by either lipopolysaccharide (LPS), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length Spike protein (FL-Spike), or mycotoxin ochratoxin A (OTA). Human were preincubated with (10, 50, 100 µM) for h, following which, they 24 h. The inflammatory mediators interleukin-1 beta (IL-1β), chemokine (C-X-C motif) ligand 8 (CXCL8), IL-6, matrix metalloproteinase-9 (MMP-9) quantified culture supernatant enzyme-linked immunosorbent assay (ELISA). Both significantly inhibited LPS, FL-Spike, OTA-stimulated release IL-1β, CXCL8, MMP-9 at 50 µM, while, most cases, was also effective 10 pronounced reductions µM. These findings suggest that both are potent inhibitors pathogen-stimulated microglial mediators, highlighting their potential therapeutic application neuroinflammatory diseases, such as long COVID.
Language: Английский
Citations
1
Translational Research in Anatomy, Journal Year: 2025, Volume and Issue: unknown, P. 100395 - 100395
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17
Published: March 27, 2025
Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.
Language: Английский
Citations
0
Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(5)
Published: May 1, 2025
ABSTRACT Safflower seed oil is one of the eight major resources worldwide, generating substantial byproducts after extraction each year. Efficient recycling and utilization these are critical for sustainability. This study explored potential use safflower coating by isolating bioactive compounds evaluating their functionality. Extraction methods to isolate phenylpropanoid amides 5‐hydroxytryptamine (PAHA), specifically coumaroyl‐5‐hydroxytryptamine (CS) feruloyl‐5‐hydroxytryptamine (FS), were first optimized results demonstrated that PAHA was highly presented in coating. The bioactivity systematically evaluated, showing extract exhibited antioxidant capacity. In vitro anti‐inflammatory assays PAHA‐enriched had remarked inhibitive capability on bovine serum albumin denaturation, erythrocyte membrane lysis, lipoxygenase (LOX) activity. an IPEC‐J2 cell model, significantly attenuated E. coli ‐induced inflammatory responses, resulting reduced expression genes proinflammatory markers IL‐1α, IL‐6, TNF‐α, COX‐2. Further analysis molecular docking suggesting strong binding affinities between two independent components (CS FS) key enzymes COX‐2 5‐LOX. current revealed excellent from coating, which could be utilized future as a naturally derived dual COX/LOX inhibitor food preservatives or functional food.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13275 - 13275
Published: Dec. 11, 2024
Endothelial cells (ECs) are crucial for vascular health, regulating blood flow, nutrient exchange, and modulating immune responses inflammation. The impairment of these processes causes the endothelial dysfunction (ED) characterized by oxidative stress, inflammation, permeability, extracellular matrix remodeling. While primary ECs have been widely used to study ED in vitro, their limitations—such as short lifespan donor variability—pose challenges. In this context, induced iECs derived from pluripotent stem offer an innovative solution, providing unlimited source explore disease-specific features ED. Recent advancements 3D models microfluidic systems enhanced physiological relevance iEC-based better mimicking microenvironment. These innovations bridge gap between understanding mechanisms drug developing screening prevent or treat This review highlights current state iEC technology a model non-vascular disorders, including diabetes, cardiovascular, neurodegenerative diseases.
Language: Английский
Citations
0
Journal of Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 132, P. 110997 - 110997
Published: Dec. 26, 2024
Language: Английский
Citations
0