The superior colliculus

Current Biology, Journal Year: 2025, Volume and Issue: 35(5), P. R164 - R168

Published: March 1, 2025

Language: Английский

---

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 22, 2025

Visual perception can operate in two distinct vision modes-static and dynamic-that have been associated with different neural activity regimes the superior colliculus (SC). However, pathway-wide mechanisms remain poorly understood, especially terms of corticotectal tectotectal feedback upon encoding continuity illusion during dynamic mode. Here, we harness functional MRI combined rat brain lesions to investigate whole-pathway interactions We find a push-pull mechanism embodying contralateral suppression SC opposing positive ipsilateral activation monocular visual stimulation. Cortical amplification is confirmed through cortical lesions, while further lesioning leads boost negative signals, suggesting tectal origin for interaction. These results highlight hitherto unreported frequency-dependent modulations pathway challenge notion that intertectal connections solely serve as reciprocal inhibitory avoiding blur saccades.

Language: Английский

---

Neural mechanisms for the localization of unexpected external motion

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 30, 2023

To localize objects during active sensing, animals must differentiate stimuli caused by volitional movement from real-world object motion. determine a neural basis for this ability, we examined the mouse superior colliculus (SC), which contains multiple egocentric maps of sensorimotor space. By placing mice in whisker-guided virtual reality, discovered rapidly adapting tactile response that transiently emerged externally generated gains whisker contact. Responses to self-generated touch matched history were significantly attenuated, revealing transient magnitude is controlled predictions. The gradually decreased with repetitions external motion, slow habituation based on history. direction motion was accurately encoded firing rates responsive neurons. These data reveal whisker-specific adaptation and predictions SC neurons enhance localization unexpected, changes

Language: Английский

---

Single-Nucleus RNA Sequencing of Developing and Mature Superior Colliculus Identifies Neuronal Diversity and Candidate Mediators of Circuit Assembly

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 2, 2023

The superior colliculus (SC) is a sensorimotor structure in the midbrain that integrates input from multiple sensory modalities to initiate motor commands. It undergoes well-characterized steps of circuit assembly during development, rendering mouse SC popular model study establishment and refinement neural connectivity. Here we performed single nucleus RNA-sequencing analysis isolated at various developmental time points. Our provides transcriptomic landscape cell types comprise across murine development with particular emphasis on neuronal heterogeneity. We used these data identify Pax7 as marker for an anatomically homogeneous population GABAergic neurons. Lastly, report repertoire genes differentially expressed different postnatal ages, many which are known regulate axon guidance synapse formation. provide valuable resource interrogating mechanisms identifying markers manipulating specific populations circuits.

Language: Английский

---

Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly

Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113037 - 113037

Published: Aug. 24, 2023

The superior colliculus (SC) is a sensorimotor structure in the midbrain that integrates input from multiple sensory modalities to initiate motor commands. It undergoes well-characterized steps of circuit assembly during development, rendering mouse SC popular model study establishment neural connectivity. Here we perform single-nucleus RNA-sequencing analysis isolated at various developmental time points. Our provides transcriptomic landscape cell types comprise across murine development with particular emphasis on neuronal heterogeneity. We report repertoire genes differentially expressed different postnatal ages, many which are known regulate axon guidance and synapse formation. Using these data, find Pax7 expression restricted subset GABAergic neurons. data provide valuable resource for interrogating mechanisms identifying markers manipulating specific populations circuits.

Language: Английский

---

A binocular perception deficit characterizes prey pursuit in developing mice

iScience, Journal Year: 2022, Volume and Issue: 25(11), P. 105368 - 105368

Published: Oct. 17, 2022

Integration of binocular information at the cellular level has long been studied in mouse model to uncover fundamental developmental mechanisms underlying mammalian vision. However, we lack an understanding corresponding ontogeny visual behavior mice that relies on integration. To address this major outstanding question, quantified natural visually guided postnatal day 21 (P21) and adult using a live prey capture assay computerized-spontaneous perception objects task (C-SPOT). We found robust specific field processing deficit P21 as compared adults corresponded selective increase c-Fos expression anterior superior colliculus (SC) juveniles after C-SPOT. These data link developing activity changes SC.

Language: Английский

---

Visual spatial location influences selection of instinctive behaviours in mouse

Royal Society Open Science, Journal Year: 2023, Volume and Issue: 10(4)

Published: April 1, 2023

Visual stimuli can elicit instinctive approach and avoidance behaviours. In mouse, vision is known to be important for both of an overhead threat toward a potential terrestrial prey. The used characterize these behaviours, however, vary in spatial location (overhead or near the ground plane) visual feature (rapidly expanding disc slowly moving disc). We therefore asked how mice responded same features presented each location. found that looming black induced escape behaviour when side animal, but escapes produced by side-looms were less vigorous often preceded freezing behaviour. Similarly, small discs sweeps also elicited such explored area arena where stimulus had been presented. Our observations show combine cues selecting among

Language: Английский

---

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Abstract Visual perception can operate in two distinct vision modes - static and dynamic that have been associated with different neural activity regimes the superior colliculus (SC). The mode (low flashing frequencies) is strong SC activation modulated by cortical gain inhibitory intertectal effects, while (high evokes continuity illusion, suppression of activity. However, pathway-wide mechanisms underpinning remain poorly understood, especially terms corticotectal tectotectal feedback. Here, we harness rat functional MRI combined brain lesions to investigate whole-pathway interactions mode. In SC, find contralateral opposing positive ipsilateral upon monocular visual stimulation A amplification effect was confirmed for both through lesions, further lesioning led a boost negative signals, suggesting an active push-pull interaction between SCs during regime. This specific mode; mode, show similar response polarities. These results highlight hitherto unreported frequency-dependent modulations pathway challenge contemporary notion connections solely serve as reciprocal avoiding blur saccade occurrence. One Sentence Summary Opposing signals colliculi suggest within commissural pathway.

Language: Английский

---

Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory

Quantitative Imaging in Medicine and Surgery, Journal Year: 2024, Volume and Issue: 14(7), P. 4972 - 4986

Published: June 29, 2024

Working memory refers to a process of temporary storage and manipulation information support planning, decision-making, action. Frequently comorbid alcohol misuse sleep deficiency have both been associated with working deficits. However, how interact impact remains unclear. In this study, we aim investigate the neural processes inter-relating misuse, memory.

Language: Английский

---

Brain-wide arousal signals are segregated from movement planning in the superior colliculus

Published: Aug. 21, 2024

The superior colliculus (SC) is traditionally considered a brain region that functions as an interface between processing visual inputs and generating eye movement outputs. Although its role primary reflex center thought to be conserved across vertebrate species, evidence suggests the SC has evolved support higher-order cognitive including spatial attention. When it comes oculomotor areas such SC, critical high precision fixation movements are maintained even in presence of signals related ongoing changes cognition state, both which have potential interfere with position encoding generation. In this study, we recorded spiking responses neuronal populations while monkeys performed memory-guided saccade task found activity some neurons fluctuated over tens minutes. By leveraging statistical power afforded by high-dimensional recordings, were able identify low-dimensional pattern was correlated subjects’ arousal levels. Importantly, deep-layer less brain-wide signal, neural associated pupil size tuning did not overlap population space initiation signals. Taken together, these findings provide framework for understanding how can embedded structures without compromising fidelity motor output.

Language: Английский

---