Perineuronal nets in motor circuitry regulate the performance of learned vocalizations in songbirds

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 18, 2025

The accurate and reliable performance of learned vocalizations (e.g., speech birdsong) modulates the efficacy communication in humans songbirds. Consequently, it is critical to understand factors that regulate vocalizations. Across taxa, neural circuits underlying motor learning control are replete with perineuronal nets (PNNs), we analyzed how PNNs vocal circuitry song zebra finches. We report developmental increases PNN expression associated stereotypy. also document enzymatically degrading nucleus HVC acutely altered structure (changes syllable sequencing production). Collectively, our data reveal a causal contribution behaviors and, given parallels regulation birdsong speech, suggest could modulate performance.

Language: Английский

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Perineuronal nets in the rat medial prefrontal cortex alter hippocampal-prefrontal oscillations and reshape cocaine self-administration memories

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 6, 2024

Abstract The medial prefrontal cortex (mPFC) is a major contributor to relapse cocaine in humans and reinstatement behavior rodent models of use disorder. Output from the mPFC modulated by parvalbumin (PV)-containing fast-spiking interneurons, majority which are surrounded perineuronal nets (PNNs). Here we tested whether chondroitinase ABC (ABC)- mediated removal PNNs prevented acquisition or reconsolidation self-administration memory. injections into dorsal prior training attenuated self-administration. Also, given 3 days but not 1 hr after memory reactivation blocked cue-induced reinstatement. However, reduced was present only rats novel contingency, suggesting that required for updating familiar In naive rats, did alter excitatory inhibitory puncta on PV cells intensity. Whole-cell recordings revealed greater inter-spike interval ABC, later. vivo hippocampus (dHIP) during reward-associated increases beta gamma activity as well phase-amplitude coupling between dHIP mPFC. Together, our findings show PNN attenuates memories disrupts original when combined with session. Further, dHIP/mPFC may serve key biomarker how disrupt reduce relapse.

Language: Английский

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Perineuronal nets in the rat medial prefrontal cortex alter hippocampal-prefrontal oscillations and reshape cocaine self-administration memories

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(34), P. e0468242024 - e0468242024

Published: July 11, 2024

The medial prefrontal cortex (mPFC) is a major contributor to relapse cocaine in humans and reinstatement rodent models of use disorder. output from the mPFC potently modulated by parvalbumin (PV)-containing fast-spiking interneurons, majority which are surrounded perineuronal nets. We previously showed that treatment with chondroitinase ABC (ABC) reduced consolidation reconsolidation conditioned place preference memory. However, self-administration memories more difficult disrupt. Here we report male rats attenuated blocked was when were given novel, but not familiar, type retrieval session. Furthermore, prior to, after, memory reconsolidation. This same did alter sucrose memory, indicating specificity for cocaine-induced In naive rats, altered levels PV intensity cell firing properties. vivo recordings dorsal hippocampus (dHIP) during novel session revealed prevented reward-associated increases high-frequency oscillations synchrony these between dHIP mPFC. Together, this first study show disrupts original combined elicits coupling after may serve as fundamental signature how disrupt reduce relapse.

Language: Английский

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Numerical Investigation of Innovative Photovoltaic–Thermal (PVT) Collector Designs for Electrical and Thermal Enhancement

Energies, Journal Year: 2024, Volume and Issue: 17(10), P. 2429 - 2429

Published: May 19, 2024

Photovoltaic–thermal (PVT) technology is gaining popularity due to the diminishing availability of traditional fossil fuels and escalating environmental concerns. Enhancing heat dissipation PVT improve its electrical thermal performance remains a significant task. This study simulates thermodynamic transfer characteristics in multiple novel structures by examining impact various factors such as collector materials, radiation intensity, mass flow rate, inlet temperature. work also identifies optimal rate for locations with different solar radiation. The numerical results indicate that efficiency designed cylindrical structure has increased 1.73% while 8.29%. Aluminum identified most cost-effective material collector. rates selected Xining, Taiyuan, Turpan are 0.36 kg/s, 0.35 0.30 respectively. provide valuable insight into optimizing design operating conditions systems.

Language: Английский

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Perineuronal nets in motor circuitry regulate the performance of learned vocalizations in songbirds

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

ABSTRACT The accurate and reliable production of learned behaviors can be important for survival reproduction; example, the performance vocalizations (e.g., speech birdsong) modulates efficacy social communication in humans songbirds. Consequently, it is critical to understand factors that regulate behaviors. Across various taxa, neural circuits motor learning are replete with perineuronal nets (PNNs), extracellular matrices surround neurons shape dynamics plasticity. Perineuronal sensory cognitive processes have been found affect processing behavioral However, function PNNs remains largely unknown. Here, we analyzed causal contribution circuitry Songbirds like zebra finch powerful models this endeavor because their songs regulated by activity within discrete specialized (i.e., song system) dense PNNs. We first report developmental increases density intensity throughout system [including nucleus HVC (acronym used as proper name)] associated performance. next discovered enzymatically degrading acutely affected In particular, PNN degradation caused structure deviate from pre-surgery due changes syllable sequencing production. Collectively, our data provide compelling evidence a SIGNIFICANCE STATEMENT Motor (PNNs) but little known about how vocal modulate ability songbirds consistently produce songs. expression were perform song. Moreover, reduced adult birds accurately Our findings indicate and, expressed brain areas regulating speech, suggest could humans.

Language: Английский

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Motor cortex perineuronal net modulation improves motor function in a Parkinson's disease mouse model

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Abstract The 6-OHDA mouse model recapitulates midbrain dopaminergic cell loss and associated motor deficits akin to those observed in Parkinson’s disease. Emerging evidence suggests that modulating interneurons the primary cortex could offer a means mitigate symptoms. In cortex, perineuronal nets (PNNs), specialized extracellular matrix structure generally present around fast-spiking parvalbumin interneurons, can modulate neural activity circuit plasticity. We found removing PNNs through unilateral or bilateral ChABC injection temporarily altered behavior. Surprisingly, reduced are two weeks after lesions, whereas five lesion, return control levels. Subsequent injections significantly improved function animals only when with stimulation involving enriched housing daily training. Thus, PNN modulation of disease enables local circuits adapt inputs, resulting

Language: Английский

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