International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(23), P. 15262 - 15262
Published: Dec. 3, 2022
Unilateral
inner
ear
injury
is
followed
by
behavioral
recovery
due
to
central
vestibular
compensation.
The
therapeutic
effect
of
oxytocin
(OT)
on
compensation
was
investigated
testing
in
a
rat
model
unilateral
neurectomy
(UVN).
Animals
the
group
(UVN-OT)
exhibited
delayed
qualitative
scale
deficits
and
aggravated
static
postural
(bearing
surface)
compared
animals
NaCl
(UVN-NaCl).
Surprisingly,
oxytocin-treated
adopt
different
strategy
than
untreated
animals.
Instead
shifting
their
weight
ipsilesional
paws
(left
front
hind
paws),
they
shift
(right
left)
without
modification
along
lateral
axis.
Furthermore,
some
locomotor
strategies
compensate
for
loss
are
also
altered
treatment.
UVN-OT
do
not
induce
an
increase
distance
traveled,
mean
velocity
lower
that
control
group,
body
rotations
from
7
30
days
after
UVN.
This
study
reveals
treatment
hinders
restoration
while
improving
others
following
lesions.
mechanisms
action
support
these
changes
remain
be
elucidated.
International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
53(4)
Published: Feb. 23, 2024
The
vestibular
system
may
have
a
critical
role
in
the
integration
of
sensory
information
and
maintenance
cognitive
function.
A
dysfunction
has
significant
impact
on
quality
life.
Recent
research
provided
evidence
connection
between
functions,
such
as
spatial
memory,
navigation
attention.
Although
exact
mechanisms
linking
to
cognition
remain
elusive,
researchers
identified
various
pathways.
Vestibular
lead
degeneration
cortical
network
regions
adversely
affect
synaptic
plasticity
neurogenesis
hippocampus,
ultimately
contributing
neuronal
atrophy
cell
death,
resulting
memory
visuospatial
deficits.
Furthermore,
extent
impairment
varies
depending
specific
type
disease.
In
present
study,
current
literature
was
reviewed,
potential
causal
relationships
performance
were
discussed
directions
for
future
proposed.
Current Opinion in Neurology,
Journal Year:
2023,
Volume and Issue:
37(1), P. 52 - 58
Published: Nov. 27, 2023
Purpose
of
review
The
vestibular
system
provides
three-dimensional
idiothetic
cues
for
updating
one's
position
in
space
during
head
and
body
movement.
Ascending
signals
reach
entorhinal
hippocampal
networks
via
head-direction
pathways,
where
they
converge
with
multisensory
information
to
tune
the
place
grid
cell
code.
Recent
findings
Animal
models
have
provided
insight
neurobiological
consequences
lesions
cerebral
controlling
spatial
cognition.
Multimodal
imaging
combined
behavioural
testing
orientation
navigation
performance
as
well
strategy
last
years
helped
decipher
vestibular-cognitive
interactions
also
humans.
Summary
This
will
update
current
knowledge
on
anatomical
cellular
basis
contributions
from
a
translational
perspective
(animal
human
studies),
delineate
functional
different
pathologies
these
cognitive
domains,
lastly
speculate
potential
role
dysfunction
aging
impeding
impairment
analogy
known
effects
hearing
loss.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: March 27, 2024
The
vestibular
system
plays
an
important
role
in
maintaining
balance
and
posture.
It
also
contributes
to
vertical
perception,
body
awareness
spatial
navigation.
In
addition
its
sensory
function,
the
has
direct
connections
key
areas
responsible
for
higher
cognitive
functions,
such
as
prefrontal
cortex,
insula
hippocampus.
Several
studies
have
reported
that
dysfunction,
particular
bilateral
vestibulopathy,
is
associated
with
increased
risk
of
impairment
development
dementias
Alzheimer’s
disease.
However,
it
still
controversial
whether
there
a
causal
relationship
between
damage
dysfunction.
this
mini-review,
we
will
explore
system,
dysfunction
dementia,
hypotheses
about
hypothesis
causes
may
explain
phenomenon
some
potential
confounders
lead
impairment.
We
review
multimodal
neuroimaging
approaches
investigated
structural
functional
effects
on
cortico-vestibular
network
finally,
describe
management
patients
who
shown
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(5), P. 523 - 523
Published: May 14, 2025
Impaired
motor
function
is
a
defining
characteristic
of
Parkinson’s
disease
(PD).
Galvanic
vestibular
stimulation
(GVS)
has
been
proposed
as
potential
non-invasive
intervention
to
enhance
performance;
however,
its
efficacy
depends
on
both
parameters
and
electrode
configuration.
In
this
study,
we
examined
the
effects
two-pole
three-pole
GVS
configurations,
utilising
different
parameters,
performance
in
individuals
with
PD.
Twelve
participants
PD
were
administered
eight
distinct
subthreshold
amplitude-modulated
stimuli,
along
sham
stimulation,
while
performing
visuomotor
target
tracking
task.
Analysis
error
demonstrated
substantial
inter-individual
variability
response
stimuli
configurations.
While
configuration
yielded
superior
some
cases,
was
more
effective
others.
The
most
overall
stimulus
across
all
subjects,
characterised
by
an
envelope
frequency
30
Hz
carrier
110
Hz,
improved
25%
relative
stimulus.
Moreover,
tailoring
individual
further
enhanced
additional
24%.
These
findings
suggest
that
can
yield
significant
improvements
Furthermore,
individualised
optimisation
including
selection
appropriate
configuration,
may
therapeutic
efficacy.
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 14, 2023
This
study
aims
to
investigate
the
presence
of
spatial
cognitive
impairments
in
patients
with
acute
unilateral
peripheral
vestibulopathy
(vestibular
neuritis,
AUPV)
during
both
phase
and
recovery
phase.A
total
72
AUPV
(37
right-sided
35
left-sided
AUPV;
aged
34-80
years,
median
60.5;
39
males,
54.2%)
healthy
controls
(HCs;
43-75
59;
20
57.1%)
participated
study.
Patients
underwent
comprehensive
neurotological
assessments,
including
video-oculography,
video
head
impulse
caloric
tests,
ocular
cervical
vestibular-evoked
myogenic
potentials,
pure-tone
audiometry.
Additionally,
Visual
Object
Space
Perception
(VOSP)
battery
was
used
evaluate
visuospatial
perception,
while
Block
design
test
Corsi
block-tapping
assessed
memory
within
first
2
days
(acute
phase)
4
weeks
after
symptom
onset
(recovery
phase).Although
were
able
successfully
perform
perception
tasks
normal
parameters,
they
demonstrated
statistically
worse
performance
on
tests
compared
HCs
phase.
When
comparing
right
versus
left
groups,
significant
decreased
scores
observed
group
relative
group.
In
phase,
showed
substantial
improvements
even
these
previously
diminished
performances.AUPV
different
cognition
responses,
like
memory,
depending
affected
ear,
improving
vestibular
compensation
over
time.
We
advocate
objective
subjective
assessments
development
detect
potential
deficits
impairments.
BMC Neurology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 23, 2024
Abstract
Background
Deficits
in
spatial
memory,
orientation,
and
navigation
are
often
neglected
early
signs
of
cognitive
impairment
or
loss
vestibular
function.
Real-world
tests
require
complex
setups.
In
contrast,
simple
pointing
at
targets
a
three-dimensional
environment
is
basic
sensorimotor
ability
which
provides
an
alternative
measure
orientation
memory
bedside.
The
aim
this
study
was
to
test
the
reliability
previously
established
3D-Real-World
Pointing
Test
(3D-RWPT)
patients
with
due
different
neurodegenerative
disorders,
bilateral
vestibulopathy,
combination
both
compared
healthy
participants.
Methods
3D-RWPT
performed
using
static
array
front
seated
participant
before
and,
as
transformation
task,
after
90-degree
body
rotation
around
yaw-axis.
Three
groups
were
enrolled:
(1)
chronic
vestibulopathy
(BVP)
normal
cognition
(
n
=
32),
(2)
function
28),
(3)
combined
BVP
9).
control
group
consisted
age-matched
participants
(HP)
without
deficits
67).
Analyses
focused
on
paradigm-specific
mean
angular
deviation
azimuth
(horizontal)
polar
(vertical)
planes,
preferred
strategy
(egocentric
allocentric),
resulting
shape
configuration
relative
stimulus
array.
Statistical
analysis
age-corrected
ANCOVA-testing
Bonferroni
correction
correlation
Spearman’s
rho.
Results
Patients
employed
more
egocentric
strategies
while
but
HP
used
world-based
solutions
(pBonf
5.78
×
10-3**).
Differences
accuracy
only
found
plane,
unveiling
unique
patterns
where
showed
decreased
tasks
<
0.001***)
struggled
post-rotation
0.001***).
Overall
performance
still
adequate
some
significantly
when
deficit.
Conclusion
fast
memory.
Cognitive
led
shift
from
allocentric
less
controls.
This
supports
view
that
hinder
mental
buildup
pattern
represented
geometrical
form.
Vestibular
hypofunction
negatively
affected
plane.
most
severe
impairments
(angular
deviation,
figure
frame
configuration)
deficits.
Current Neuropharmacology,
Journal Year:
2024,
Volume and Issue:
22(11), P. 1826 - 1845
Published: March 20, 2024
Most
neurotransmitter
systems
are
represented
in
the
central
and
peripheral
vestibular
system
thereby
involved
both
normal
signal
processing
pathophysiology
of
disorders.
However,
there
is
a
special
relationship
between
histaminergic
system.
The
purpose
this
review
to
document
how
interferes
with
pathological
function.
In
particular,
we
will
discuss
neurobiological
mechanisms
such
as
neuroinflammation
that
involve
histamine
modulate
allow
restoration
balance
function
situation
insult.
These
adaptive
represent
targets
pharmacological
compounds
capable
restoring
situations.
clinical
use
drugs
targeting
various
disorders
critically
discussed.
