40 Hz Visual Stimulation During Sleep Evokes Neuronal Gamma Activity in NREM and REM Stages DOI Creative Commons
Laura Hainke, James Dowsett, Manuel Spitschan

et al.

SLEEP, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Study Objectives Visual stimulation (VS) at 40 Hz is being tested as a non-invasive approach against dementias such Alzheimer’s disease. Applying it during sleep could increase the convenience, duration, and efficacy of stimulation. Here, we feasibility VS in proof-of-concept study. Methods Thirty healthy participants underwent one control experimental night polysomnography laboratory. was delivered wakefulness (W), NREM stages 2 3, REM sleep. Results As expected, EEG spectral power increased all four condition, compared to control. It highest W similar across 2, REM, with large medium effect sizes, respectively. Steady-state visually evoked potential (SSVEP) analyses time domain confirmed specificity effect. Secondary revealed that intervention did not impair objective subjective quality beyond first-night Conclusions effectively neuronal gamma activity frequency without degrading quality, supporting this approach. These findings lay groundwork for optimizing gamma-band sensory tool causally study cognitive functions scalable, dementias.

Language: Английский

Unveiling the mTOR pathway modulation by SGLT2 inhibitors: a novel approach to Alzheimer’s disease in type 2 diabetes DOI

Prakash Ramakrishan,

Jayaraman Rajangam,

Shaheedha Shabudeen Mahinoor

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(3)

Published: Feb. 26, 2025

Language: Английский

Citations

1
40 Hz Visual Stimulation During Sleep Evokes Neuronal Gamma Activity in NREM and REM Stages DOI Creative Commons
Laura Hainke, James Dowsett, Manuel Spitschan

et al.

SLEEP, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Study Objectives Visual stimulation (VS) at 40 Hz is being tested as a non-invasive approach against dementias such Alzheimer’s disease. Applying it during sleep could increase the convenience, duration, and efficacy of stimulation. Here, we feasibility VS in proof-of-concept study. Methods Thirty healthy participants underwent one control experimental night polysomnography laboratory. was delivered wakefulness (W), NREM stages 2 3, REM sleep. Results As expected, EEG spectral power increased all four condition, compared to control. It highest W similar across 2, REM, with large medium effect sizes, respectively. Steady-state visually evoked potential (SSVEP) analyses time domain confirmed specificity effect. Secondary revealed that intervention did not impair objective subjective quality beyond first-night Conclusions effectively neuronal gamma activity frequency without degrading quality, supporting this approach. These findings lay groundwork for optimizing gamma-band sensory tool causally study cognitive functions scalable, dementias.

Language: Английский

Citations

0