Science Translational Medicine,
Journal Year:
2022,
Volume and Issue:
14(666)
Published: Oct. 12, 2022
A
confluence
of
advances
in
biosensor
technologies,
enhancements
health
care
delivery
mechanisms,
and
improvements
machine
learning,
together
with
an
increased
awareness
remote
patient
monitoring,
has
accelerated
the
impact
digital
across
nearly
every
medical
discipline.
Medical
grade
wearables—noninvasive,
on-body
sensors
operating
clinical
accuracy—will
play
increasingly
central
role
medicine
by
providing
continuous,
cost-effective
measurement
interpretation
physiological
data
relevant
to
status
disease
trajectory,
both
inside
outside
established
settings.
Here,
we
review
current
technologies
highlight
critical
gaps
translation
adoption.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(2), P. 122 - 122
Published: Feb. 14, 2025
Over
the
past
three
decades,
vagus
nerve
stimulation
(VNS)
has
emerged
as
a
promising
rehabilitation
therapy
for
diverse
range
of
conditions,
demonstrating
substantial
clinical
potential.
This
review
summarizes
in
vivo
biological
mechanisms
activated
by
VNS
and
their
corresponding
applications.
Furthermore,
it
outlines
selection
parameters
equipment
implementation.
exhibits
anti-inflammatory
effects,
modulates
neurotransmitter
release,
enhances
neural
plasticity,
inhibits
apoptosis
autophagy,
maintains
blood-brain
barrier
integrity,
promotes
angiogenesis.
Clinically,
been
utilized
treatment
epilepsy,
depression,
headache,
stroke,
obesity.
Its
potential
applications
extend
to
management
cardiovascular
cerebrovascular
diseases
various
brain
disorders.
However,
further
experiments
are
required
definitively
establish
efficacy
VNS's
mechanisms.
Additionally,
there
is
need
explore
identify
optimal
different
diseases.
Cells,
Journal Year:
2023,
Volume and Issue:
12(12), P. 1632 - 1632
Published: June 15, 2023
Type
2
diabetic
mellitus
(T2DM)
is
a
common
chronic
disease
and
substantial
risk
factor
of
other
fatal
illnesses.
At
its
core
insulin
resistance,
where
low-level
inflammation
among
main
causes.
Thus,
it
crucial
to
modulate
this
inflammation.
This
review
paper
provides
scientific
neuroimmunological
evidence
on
the
protective
roles
vagal
nerve
in
T2DM.
First,
vagus
inhibits
reflexive
manner
via
neuroendocrine
routes.
may
also
occur
at
level
brain
networks.
Second,
studies
have
shown
that
activity,
as
indexed
by
heart-rate
variability
(HRV),
inversely
related
diabetes
low
HRV
predictor
Finally,
some
emerging
shows
activation
reduce
biomarkers
processes
diabetes.
Future
randomized
controlled
trials
are
needed
test
effects
T2DM
underlying
anti-inflammatory
mechanisms.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Aug. 16, 2024
Background
Transcutaneous
Vagal
Nerve
Stimulation
(tVNS)
has
been
used
as
a
promising
noninvasive
neuromodulation
technique
for
the
treatment
of
various
systems.The
aim
this
study
was
to
analyze
research
hotspots
and
future
directions
tVNS
in
21st
century
by
using
bibliometric
methods.
Methods
The
object
literature
related
from
Web
Science
database
2000
May
2024.
In
order
measure
number
issuance,
institutions,
authors,
countries,
keywords,
co-citations,
journals
publication,
we
VOSviewer,
Citespace,
Bibliometrix
R-package,
Scimago
Graphica
software.
A
narrative
review
current
content
conducted
gain
better
understanding
state
field.
Results
total
569
papers
were
included
study.
results
show
that
2024,
publications
shows
an
increasing
trend
year
year,
involving
326
institutions.
United
States,
China,
Germany
are
major
centers.
identified
399
which
roughly
formed
11
natural
clusters,
revealing
mainly
reflected
3
areas:
intervention
efficacy
on
nervous
system
diseases,
mechanism
action
tVNS,
stimulation
mode
tVNS.
top
10
most
cited
references
focus
into
Conclusion
safety
have
confirmed
previous
studies,
but
standardized
protocol
not
yet
developed,
clinical
studies
small
sample
sizes
lack
multicenter
multidisciplinary
collaboration.
Currently,
is
neurological
psychiatric
cardiovascular
some
autoimmune
diseases.
It
expected
field
will
continue
application
central
diseases
exploration
mechanisms,
at
same
time,
with
rise
non-invasive
technology,
other
also
great
potential
development.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Sept. 23, 2024
As
medical
research
advances
and
technology
rapidly
develops,
auricular
acupuncture
has
emerged
as
a
point
of
growing
interest.
This
paper
delves
into
the
intricate
anatomy
points,
their
significance
therapeutic
principles
in
traditional
Chinese
medicine
(TCM),
underlying
mechanisms
contemporary
medicine.
The
aim
is
to
delve
deeply
this
ancient
mysterious
tradition,
unveiling
its
multi-layered
mysteries
field
neurostimulation.
anatomical
structure
points
complex
delicate,
unique
neurovascular
network
grants
them
special
status
neurostimulation
therapy.
Through
exploration
these
features,
we
not
only
comprehend
position
TCM
theory
but
also
provide
profound
foundation
for
modern
applications.
systematic
review,
synthesize
insights
from
research.
Building
upon
classical
theoretical
foundations,
focus
on
encompasses
neuroregulation,
pain
management,
psychological
wellbeing,
metabolic
disorders,
immune
modulation.
latest
clinical
confirms
efficacy
stimulation
alleviating
symptoms
modulating
diseases
at
endocrine
level
underscores
potential
role
regulating
patients’
wellbeing.
article
aims
promote
comprehensive
understanding
by
demonstrating
diverse
applications
providing
substantial
evidence
support
broader
adoption
practice.
Frontiers in Physiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 9, 2024
This
systematic
review
aims
to
comprehensively
analyze
the
efficacy
and
underlying
mechanisms
of
vagus
nerve
stimulation
(VNS)
in
enhancing
cognitive
functions
its
therapeutic
potential
for
various
impairments.
The
focuses
on
impact
VNS
emotional
processing,
executive
functions,
learning,
memory,
clinical
applications
conditions
such
as
epilepsy,
depression,
Alzheimer's
disease,
other
neurological
disorders.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 12, 2022
Non-invasive
transcutaneous
auricular
vagus
nerve
stimulation
(taVNS)
as
a
newly
developed
technique
involves
stimulating
the
cutaneous
receptive
field
formed
by
branch
of
in
outer
ear,
with
resulting
activation
vagal
connections
to
central
and
peripheral
nervous
systems.
Increasing
evidence
indicates
that
maladaptive
neural
plasticity
may
underlie
pathology
several
pediatric
neurodevelopmental
psychiatric
disorders,
such
autism
spectrum
disorder,
attention
deficit
hyperactivity
disruptive
behavioral
disorder
stress-related
disorder.
Vagal
therefore
provide
useful
intervention
for
treating
plasticity.
In
current
review
we
summarize
literature
primarily
on
therapeutic
use
adults
discuss
prospects
applying
taVNS
specific
other
disorders.
Furthermore,
also
briefly
factors
would
help
optimize
protocols
future
clinical
applications.
We
conclude
from
these
initial
findings
be
promising
alternative
treatment
disorders
which
do
not
respond
interventions.
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Neuromodulation
comes
into
focus
as
a
non-pharmacological
therapy
with
the
vagus
nerve
modulation
target.
The
auricular
stimulation
(aVNS)
has
emerged
to
treat
chronic
diseases
while
re-establishing
sympathovagal
balance
and
activating
parasympathetic
anti-inflammatory
pathways.
aVNS
leads
still
over
under-stimulation
is
limited
in
therapeutic
efficiency.
A
potential
avenue
personalization
of
based
on
time-varying
cardiorespiratory
rhythms
human
body.
In
pilot
study,
we
propose
personalized
cardiac-gated
evaluate
its
effects
instantaneous
beat-to-beat
intervals
(RR
intervals).
Modulation
RR
expected
reveal
efficiency
since
efferent
cardiac
branch
stimulated
afferent
governs
RR.
Five
healthy
subjects
were
subjected
aVNS.
Each
subject
underwent
two
25-min
sessions.
first
session
started
non-gated
open-loop
aVNS,
followed
by
systole-gated
closed-loop
then
non-gated,
diastole-gated,
each
for
5min.
second
session,
systole
diastole
gated
interchanged.
Changes
are
analysed
comparing
prolongation
respect
proceeding
interval
where
took
place.
These
changes
considered
function
onset,
angle
starting
R
peak.
influence
respiration
phases
cardiovagal
modulation.
results
show
that
tends
prolong
shorten
when
after
before
peak,
respectively.
later
time
onset
within
diastole-gated
longer
be
subsequent
interval.
tendency
raises
increasing
gradually
levels
off
delay
from
one
slope
this
rise
larger
than
When
considering
individual
phases,
inspiratory
seems
largest
values
thus
modulatory
capacity
time-gated
This
study
indicates
modulate
heartbeat
activity
which
attenuated
diseases.
highest
during
inspiration.
Bioelectronic Medicine,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Sept. 13, 2024
Abstract
The
identification
of
acute
cardioprotective
strategies
against
myocardial
ischemia/reperfusion
(I/R)
injury
that
can
be
applied
in
the
catheterization
room
is
currently
an
unmet
clinical
need
and
several
interventions
evaluated
past
at
pre-clinical
level
have
failed
translation.
Autonomic
imbalance,
sustained
by
abnormal
afferent
signalling,
a
key
component
I/R
injury.
Accordingly,
there
strong
rationale
for
neuromodulation
strategies,
aimed
reducing
sympathetic
activity
and/or
increasing
vagal
tone,
this
setting.
In
review
we
focus
on
cervical
nerve
stimulation
(cVNS)
transcutaneous
auricular
vagus
(taVNS);
latest
has
potential
to
overcome
issues
invasive
cVNS,
including
possibility
being
used
setting,
while
retaining
its
beneficial
effects.
First,
discuss
pathophysiology
injury,
mostly
consequence
overproduction
reactive
oxygen
species.
Second,
describe
functional
anatomy
parasympathetic
branch
autonomic
nervous
system
most
relevant
principles
bioelectronic
medicine
electrical
modulation,
with
particular
taVNS.
Then,
provide
detailed
comprehensive
summary
studies
non-invasive
VNS
support
effect
whenever
or
chronic
cardiac
specifically
setting
benefit
emerging
field
post
arrest
syndrome
(PCAS)
also
mentioned.
Indeed,
cVNS
anti-adrenergic,
anti-inflammatory,
antioxidants,
anti-apoptotic
pro-angiogenic
effect;
involved
molecular
pathways
were
already
directly
confirmed
take
place
Pre-clinical
data
clearly
show
sooner
applied,
better
outcome,
marked
infarct
size
reduction
almost
complete
left
ventricular
reverse
remodelling
when
immediately
before
during
reperfusion.
Finally,
detail
limited
but
very
promising
experience
taVNS
available
so
far.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Sept. 7, 2023
Stress
is
a
major
determinant
of
health
and
wellbeing.
Conventional
stress
management
approaches
do
not
account
for
the
daily-living
acute
changes
in
that
affect
quality
life.
The
combination
physiological
monitoring
non-invasive
Peripheral
Nerve
Stimulation
(PNS)
represents
promising
technological
approach
to
quantify
stress-induced
manifestations
reduce
during
everyday
This
study
aimed
evaluate
effectiveness
three
well-established
transcutaneous
PNS
modalities
reducing
compared
sham:
auricular
cervical
Vagus
(taVNS
tcVNS),
Median
(tMNS).
Using
single-blind
sham-controlled
crossover
with
four
visits,
we
mitigation
taVNS,
tcVNS,
tMNS,
quantified
through
markers
derived
from
five
signals
peripherally
measured
on
19
young
healthy
volunteers.
Participants
underwent
mental
stressors
while
receiving
stimulation.
Blinding
was
assessed
via
subjective
survey.
taVNS
tMNS
relative
sham
resulted
significant
suggest
reduction
sympathetic
outflow
following
stressors:
Left
Ventricular
Ejection
Time
Index
(LVETI)
shortening
(tMNS:
p
=
0.007,
taVNS:
0.015)
Pre-Ejection
Period
(PEP)-to-LVET
ratio
(PEP/LVET)
increase
0.044,
0.029).
also
reduced
Pulse
Pressure
(PP;
0.032)
tonic
EDA
activity
(tonicMean;
0.025).
nonsignificant
blinding
survey
results
these
effects
were
influenced
by
placebo.
effectively
arousal
wearable-compatible
signals,
motivating
their
future
use
novel
personalized
therapies
improve
