Cited by Infrared neuroglial modulation of spinal locomotor networks

Deep brain stimulation-induced two manners to eliminate bursting for Parkinson’s diseases: synaptic current and bifurcation mechanisms DOI

Hui Zhou, Xianjun Wang, Huaguang Gu

et al.

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: May 19, 2025

Language: Английский

Citations

High-throughput microelectrode arrays for functional localization of the globus pallidus internus DOI

Yuxin Zhu,

Luyi Jing,

Ruilin Hu

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

The globus pallidus internus (GPi) was considered a common target for stimulation in Parkinson’s disease (PD). Located deep the brain and of small size, pinpointing it during surgery is challenging. Multi-channel microelectrode arrays (MEAs) can provide micrometer-level precision functional localization, which maximize surgical outcome. In this paper, 64-channel MEA modified by platinum nanoparticles with detection site impedance 61.1 kΩ designed prepared, multiple channels could be synchronized to cover region its neighboring regions so that GPi identified quickly accurately. results implant trajectory indicate that, compared control side, there reduction local field potential (LFP) power subregions upper central thalamus on PD-induced while remaining exhibit an increasing trend. When tip positioned at 8,700 μm brain, various characterizations spike signals, combined electrophysiological characteristics β-segmental oscillations PD, enabled MEAs localize single-cell level. More precise localization achieved utilizing distinct internal capsule (ic), thalamic reticular nucleus (Rt), peduncular part lateral hypothalamus (PLH) regions, as well relative positions these structures. study new method tool PD targets pathogenesis cellular

Language: Английский

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基于微电极阵列探针的无线闭环脑深部刺激技术 DOI

Qianli Jia,

Yaoyao Liu,

Shiya Lv

et al.

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(10), P. 803 - 823

Published: Feb. 12, 2024

Language: Английский

Citations

Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model DOI

Justus A. Kromer,

Hemant Bokil,

Peter A. Tass

et al.

Frontiers in Neuroinformatics, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 22, 2023

The basal ganglia (BG) are involved in motor control and play an essential role movement disorders such as hemiballismus, dystonia, Parkinson's disease. Neurons the part of BG respond to passive or stimulation different body parts corresponding cortical regions. Experimental evidence suggests that organized somatotopically, i.e., specific areas associated with regions nuclei. Signals related same propagate along pathways converge onto neurons, leading characteristic shapes cortically evoked responses. This existence functional channels allow for processing commands information parallel. Neurological disease pathological activity impaired synaptic connectivity, together reorganization somatotopic maps. One hypothesis is symptoms are, at least partly, caused by impairment network structure perturbing organization channels.We developed a computational model STN-GPe circuit, central BG. By removing individual connections, we analyzed contribution signals propagating We studied how responses affected systematic changes structure. To quantify BG's form channels, suggested two-site protocol.Our reproduced STN GPe neurons contributions experimental studies. Cortical evokes spatio-temporal response patterns linked underlying Our protocol yielded approximate channel width.The presented results provide insight into which important development models. strongly affects may impact generation rhythms. work motivate further experiments analyze nuclei their channels.

Language: Английский

Citations

Mechanisms of deep brain stimulation for psychiatric disorders DOI

Concetta Brusco, Chaim Feigen, Emad N. Eskandar

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 451 - 477

Published: Jan. 1, 2024

Language: Английский

Citations

STN localization using local field potentials based on wavelet packet features and stacking ensemble learning DOI

Mohamed Hosny, Minwei Zhu, Wenpeng Gao

et al.

Journal of Neuroscience Methods, Journal Year: 2024, Volume and Issue: 407, P. 110156 - 110156

Published: May 3, 2024

Language: Английский

Citations

Infrared Neuroglial Modulation of spinal locomotor networks DOI

Nathan Dumas,

Émilie Pecchi,

Rodney P. O’Connor

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 27, 2024

Abstract Infrared neural stimulation (INS) emerges as a promising tool for stimulating the nervous system by its high spatial precision and absence of use exogenous agents into tissue, which led to first successful proof concept in human brain. While networks have been focal point INS research, this technique is also non cell type specific it triggers activity electrically excitable cells. Despite increasing interest, there remains demonstrate well defined simultaneous astrocytic neuronal signals response INS. Using intravital calcium imaging, we show that has capacity initiate signaling both astrocytes neurons simultaneously from rostral lumbar spinal cord, each exhibiting distinct temporal amplitude characteristics. Importantly, mechanism underlying infrared-induced differ, with relying on sodium channels, whereas induced predominantly influenced extracellular TRPV4 channels. Furthermore, our findings frequency shift oscillations through infrared stimulation. By deepening understanding fundamentals, holds great promise advancing neuroscience, pathologies, potentially paving way future clinical applications.

Language: Английский

Citations

Infrared neuroglial modulation of spinal locomotor networks DOI

Nathan Dumas,

Émilie Pecchi,

Rodney P. O’Connor

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 27, 2024

Language: Английский

Citations