The Impact of Inhaled Ambient Ultrafine Particulate Matter on Developing Brain: Potential Importance of Elemental Contaminants DOI Open Access
Deborah A. Cory‐Slechta, Marissa Sobolewski, Elena Marvin

et al.

Toxicologic Pathology, Journal Year: 2019, Volume and Issue: 47(8), P. 976 - 992

Published: Oct. 14, 2019

Epidemiological studies report associations between air pollution (AP) exposures and several neurodevelopmental disorders including autism, attention deficit disorder, cognitive delays. Our in mice of postnatal (human third trimester brain equivalent) to concentrated ambient ultrafine particles (CAPs) provide biological plausibility for these associations, producing numerous neuropathological behavioral features disorders, male-biased vulnerability. These findings raise questions about the specific components AP that underlie its neurotoxicity, which our suggest could involve trace elements as candidate neurotoxicants. X-ray fluorescence analyses CAP chamber filters confirm contamination by multiple elements, iron (Fe) sulfur (S). Correspondingly, laser ablation inductively coupled plasma mass spectrometry brains male indicates marked postexposure elevations Fe S other elements. Elevations particular are consistent with potential ferroptotic, oxidative stress, altered antioxidant capacity-based mechanisms CAPs-induced supported observations increased serum oxidized glutathione neuronal cell death nucleus accumbens no corresponding significant increase caspase-3, following exposures. Understanding role element contaminants particulate matter a source neurotoxicity is critical public health protection.

Language: Английский

Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches DOI Open Access

Hafza Wajeeha Ejaz,

Wei Wang, Minglin Lang

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(20), P. 7660 - 7660

Published: Oct. 16, 2020

Alzheimer’s disease (AD) is an irreversible, age-related progressive neurological disorder, and the most common type of dementia in aged people. Neuropathological lesions AD are neurofibrillary tangles (NFTs), senile plaques comprise accumulated amyloid-beta (Aβ), loaded with metal ions including Cu, Fe, or Zn. Some reports have identified dyshomeostasis as a neurotoxic factor AD, among which Cu seem to be central cationic formation plaque soluble oligomers, essential role pathology. Cu-Aβ complex catalyzes generation reactive oxygen species (ROS) results oxidative damage. Several studies indicated that stress plays crucial pathogenesis AD. The connection copper levels still ambiguous, some researches indicate deficiency, while others show its higher content therefore there need increase decrease animal models, respectively, study one cause. For more than twenty years, many vitro been devoted identifying metals’ roles Aβ accumulation, damage, neurotoxicity. Towards end, short review modern therapeutic approach chelation therapy, main focus on ions, discussed. Despite lack strong proofs clinical advantage so far, conjecture using chelator effective strategy for remains popular. However, recent genetic-regulating transporters models shed light treating this refractory disease. This aims succinctly present better understanding ions’ current status several features, conflicting herein.

Language: Английский

Citations

109
Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers DOI
Monika Rana, Anuj K. Sharma

Metallomics, Journal Year: 2018, Volume and Issue: 11(1), P. 64 - 84

Published: Sept. 14, 2018

The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ) peptides has attracted a lot attention in recent years due to its repercussions Alzheimer's disease (AD).

Language: Английский

Citations

92
Copper dyshomeostasis in Wilson disease and Alzheimer's disease as shown by serum and urine copper indicators DOI
Rosanna Squitti, Roberta Ghidoni, Ilaria Simonelli

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2017, Volume and Issue: 45, P. 181 - 188

Published: Nov. 8, 2017

Language: Английский

Citations

90
Redox active metals in neurodegenerative diseases DOI
Karla Acevedo, Shashank Masaldan, Carlos Opazo

et al.

JBIC Journal of Biological Inorganic Chemistry, Journal Year: 2019, Volume and Issue: 24(8), P. 1141 - 1157

Published: Oct. 24, 2019

Language: Английский

Citations

83
Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies DOI
Charlène Esmieu, Djamila Guettas,

Amandine Conte‐Daban

et al.

Inorganic Chemistry, Journal Year: 2019, Volume and Issue: 58(20), P. 13509 - 13527

Published: June 17, 2019

According to the amyloid cascade hypothesis, metal ions, mainly Cu and Zn bound amyloid-β (Aβ) peptides are implicated in Alzheimer's disease (AD), a widespread neurodegenerative disease. They indeed impact aggregation pathways of Aβ involved catalytic generation reactive oxygen species (ROS) that participate oxidative stress, while stress regarded as two key events AD etiology. ions due their redox ability have been considered be main potential therapeutic targets AD. A considerable number ligands developed order modulate toxicity associated with this context, via disruption Aβ-Cu interaction. Among them, small synthetic peptide scaffolds designed studied for remove from Aβ. Some those able prevent Cu(Aβ)-induced ROS production can modify vitro cellulo. Examples such gathered Viewpoint, function structures discussed respect properties against Cu(Aβ) deleterious fallouts. Nevertheless, beneficial activities most promising detected cellulo not transposed human yet. parameters might explain apparent contradiction concepts consider design "more" efficient thus reported discussed. En passant, Viewpoint sheds light on difficulties comparing results one study another hamper significant advances field.

Language: Английский

Citations

78
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease DOI
Zhipei Sang, Keren Wang, Pengfei Zhang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2019, Volume and Issue: 180, P. 238 - 252

Published: July 12, 2019

Language: Английский

Citations

77
Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights DOI Creative Commons
Nicolás Puentes‐Díaz, Diego Chaparro, David Morales‐Morales

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(5), P. 4508 - 4526

Published: Jan. 25, 2023

Alzheimer's disease (AD) is the most common form of dementia, affecting millions people around world. Even though causes AD are not completely understood due to its multifactorial nature, some neuropathological hallmarks development have been related high concentration metal cations. These roles include participation these cations in production reactive oxygen species, which involved neuronal damage. In order avoid increment oxidative stress, multifunctional ligands used coordinate proposed as a possible treatment AD. this review, we present recent advances experimental and computational works aiming understand role two redox active essential transition-metal (Cu Fe) one nonbiological (Al) proposals on stop or revert damaging effects promoted by

Language: Английский

Citations

37
Metals in Alzheimer’s Disease DOI Creative Commons
Mirjana Babić Leko,

Lea Langer Horvat,

Ena Španić Popovački

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1161 - 1161

Published: April 12, 2023

The role of metals in the pathogenesis Alzheimer’s disease (AD) is still debated. Although previous research has linked changes essential metal homeostasis and exposure to environmental heavy AD, more needed determine relationship between AD. In this review, we included human studies that (1) compared concentrations AD patients healthy controls, (2) correlated cerebrospinal fluid (CSF) biomarkers with concentrations, (3) used Mendelian randomization (MR) assess potential contributions risk. many have examined various dementia patients, understanding dynamics these remains difficult due considerable inconsistencies among results individual studies. most consistent findings were for Zn Cu, observing a decrease levels an increase Cu patients. However, several found no such relation. Because few biomarker CSF type required. Given MR revolutionizing epidemiologic research, additional include participants from diverse ethnic backgrounds causal risk are critical.

Language: Английский

Citations

36
Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease DOI
Vinay Chaudhari,

Siddhi Bagwe‐Parab,

Harpal S. Buttar

et al.

Neurotoxicity Research, Journal Year: 2023, Volume and Issue: 41(3), P. 270 - 287

Published: Jan. 27, 2023

Language: Английский

Citations

30
Nanocellulose-based functional materials for physical, chemical, and biological sensing: A review of materials, properties, and perspectives DOI
Yang Liu, Xin Xu, Meng Gao

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 212, P. 118326 - 118326

Published: March 7, 2024

Language: Английский

Citations

10